Second-line treatment of locally advanced or metastatic non-small cell research hub
5 indexed studies · 4 currently recruiting
- recruitingTherapeutic exploratory (Phase II)
A Phase 2 multicenter, randomized, placebo controlled, double-blind study to assess the safety and efficacy of CC-486 (oral azacitidine) in combination with pembrolizumab (MK-3475) versus pembrolizumab plus placebo in subjects with previously treated locally advanced or metastatic non-small cell lung cancer
This study is looking for new and better ways to treat advanced lung cancer that has already been treated. It compares a new combination of two drugs – an azacitidine tablet and pembrolizumab – against pembrolizumab with a placebo. The main goal is to see if the new combination can slow down the cancer’s growth.
Italy - recruitingTherapeutic exploratory (Phase II)
A multicentre phase II, open-label, non-randomized study evaluating Platinum-Pemetrexed-Atezolizumab ( Bevacizumab) for patients with stage IIIB/IV non-squamous non-small cell lung cancer with EGFR mutations, ALK rearrangement or ROS1 fusion progressing after Targeted therapies
This study looks at a new combination of existing medicines for a type of lung cancer (NSCLC) that has worsened after previous treatments. It aims to see how many patients respond positively to this new treatment approach.
France - recruitingPHASE2
Preoperative Amivantamab or Amivantamab and Carboplatin/Pemetrexed Treatment in Patients With Resectable Non-small-cell Lung Cancer Harboring Oncogenic EGFR Mutations (NEOpredict-EGFR)
This study is looking at giving a new treatment called amivantamab, sometimes with chemotherapy, before surgery for a certain type of lung cancer. It aims to see if this approach is practical and helpful for patients with specific gene changes in their cancer.
Belgium · Germany · Netherlands - recruiting
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling
This study is developing new blood tests for early cancer detection and to monitor how well treatment is working. It uses artificial intelligence to look at tiny particles in blood samples from people with various cancers and healthy volunteers.
Argentina · Nigeria · United Kingdom - active not recruiting
Pragmatic Analysis of Complex Radiotherapy Cases In Cancer of the Lung
This study looks at how to best treat lung cancer patients who have tricky or unusual situations. Researchers want to make radiotherapy safer and more effective, especially for those with complex conditions, to improve long-term care and help doctors explain treatment options better.
United Kingdom