Major depressive disorder (MDD) research hub
19 indexed studies · 16 currently recruiting
- authorisedTherapeutic use (Phase IV)
Effectiveness of Trazodone on Emotional Blunting in Patients with Major Depressive: a Phase IV, Open-label, clinical study
This study looks at whether an antidepressant called trazodone can reduce emotional numbness in adults with major depression. Emotional numbness means finding it hard to feel joy, sadness, or connection. Researchers will track changes in emotions, sleep, and everyday life over eight weeks of treatment with daily slow-release tablets.
Bulgaria · Poland · Hungary - recruitingHuman Pharmacology (Phase I)- Other
Effects of DLX-001 on PD, Safety, Tolerability, and PK in Participants with MDD
This study is looking at a new medicine called DLX-001 for people with depression. It's a very early-stage study to see if the medicine is safe, how the body handles it, and if people can tolerate it. This helps us learn more about potential new treatments for depression.
Netherlands - authorisedTherapeutic exploratory (Phase II)
TMSxDCS: Pharmacologically augmenting transcranial magnetic stimulation for depression
This study is looking at a new way to treat depression, using a combination of two brain stimulation methods and a medication. It aims to see how much people's depression symptoms improve over six weeks after treatment.
Netherlands - completedPhase II
The purpose of the trial is to test the safety, tolerability and efficacy of the drug tildacerfont, that is being developed for the treatment of major depressive disorder
This study is testing a new drug called tildacerfont for moderate to severe depression. It aims to see if it's safe and helps people who haven't found enough relief from current treatments. Participants will take either the drug or a dummy pill for 15 weeks.
United Kingdom · England · Scotland - recruitingPHASE3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
This study is looking into a new medication called CYB003 for adults with major depression. It aims to see if CYB003 is safe and effective when added to their current antidepressant treatment, compared to a dummy pill.
United States · Australia · Czechia - recruiting
Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
This study aims to understand why depression sometimes returns. By looking at daily habits, sleep, and brain activity, researchers hope to predict when new depressive episodes might happen, helping doctors support patients better.
Canada - recruitingNA
Home-Based tDCS for Depression in BPD
This study looks into using a special device at home called tDCS to help people with depression linked to Borderline Personality Disorder (BPD). It aims to see if it's safe, and if it helps reduce sadness and BPD symptoms, especially in rural areas.
Canada - not yet recruitingNA
Ketogenic Diet and Neuromodulation in Treatment Resistant Depression
This study looks at combining a special diet (ketogenic) with a brain stimulation treatment for people with depression that hasn't responded to other treatments. We want to see if this combination helps more than brain stimulation with a normal healthy diet.
Canada - recruitingNA
Evaluation of the Concordance Between Measures Obtained by a Medical Device for Emotional Monitoring (EMOCARE) and the Patient Health Questionnaire (PHQ-9) Score in Patients With Mild to Severe Depressive Episode
This study looks at a new app called EMOCARE for emotional monitoring in people with depression. It compares EMOCARE's results to standard questionnaires and checks how patients feel about using it to help understand and manage their mood.
France - recruitingPHASE2
A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)
This study is testing a new medication called GlyphAllo for adults with depression, with or without anxiety. It's a key step to see if it's safe and helps improve mood and reduce symptoms. Half the participants will receive the new medication and half will receive a dummy pill.
United States · Bulgaria · Czechia - recruitingNA
Group Therapy for Major Depression: Comparing Expectation-Focused and Reward-Focused Psychotherapy Approaches
This study looks into two new group therapies for depression. One helps you change negative expectations, the other boosts your ability to enjoy positive experiences. We want to see if these focused approaches can better help people with depression.
Germany - recruitingNA
Repeated Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression
This study looks at a new way to help people with depression by training their brain activity. It uses a special MRI scan to show brain activity in real-time, helping participants learn to control parts of their brain linked to mood and motivation. This could lead to better treatments.
United Kingdom - not yet recruitingNA
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)
This study is testing if a new device that uses gentle electrical pulses to stimulate a nerve near your ear can help treat depression. It compares the active device to a dummy device to see if it makes a real difference in people with major depressive disorder.
United States · United Kingdom - recruitingPHASE2
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
This study is looking into a new medication called DT-101 for adults with depression. Researchers want to see if DT-101 helps reduce depression symptoms and if it's safe compared to a dummy pill (placebo).
United States · Bulgaria · Czechia - not yet recruitingNA
Prescribing the Right Agent for Depression in Adults
This study aims to help doctors and patients choose the best antidepressant by using a new online tool. It combines personal health details, preferences, and genetic information to find the most suitable treatment for depression, hoping to improve how well people respond.
Ethiopia · Pakistan · United Kingdom - not yet recruitingPHASE2
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder
This study looks at how safe and effective psilocybin-assisted therapy is for people experiencing both depression and alcohol problems. Researchers want to see if it helps and if it has any serious side effects compared to a placebo.
Canada - recruitingPHASE1
Theta-Burst Stimulation to Treat Depression
This study looks at a brain stimulation treatment called iTBS for depression. It compares two ways of giving iTBS to see which one works better for improving mood and how the brain changes. We want to find a more effective way to help people with depression.
Canada - recruitingPHASE2, PHASE3
Understanding and Treating Suicidal Ideation With Ketamine
This study looks at whether ketamine can quickly help people with severe depression who are having thoughts of suicide. Researchers will also use brain scans and talks to understand how ketamine helps and what changes in the brain and mind.
Canada - recruitingNA
Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)
This study looks at a new way to treat depression called tDCS, which uses gentle electrical currents to the brain. It aims to see if using tDCS at home, alongside usual care, helps adults with depression more than usual care alone.
United Kingdom