Major Depressive Disorder (MDD) research hub
6 indexed studies · 4 currently recruiting
- recruitingPHASE2
A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression
This study is looking into a new medication called DT-101 for adults with depression. Researchers want to see if DT-101 helps reduce depression symptoms and if it's safe compared to a dummy pill (placebo).
United States · Bulgaria · Czechia - not yet recruitingNA
Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)
This study is testing if a new device that uses gentle electrical pulses to stimulate a nerve near your ear can help treat depression. It compares the active device to a dummy device to see if it makes a real difference in people with major depressive disorder.
United States · United Kingdom - recruitingNA
Home-Based Transcranial Direct Current Stimulation In Major Depressive Disorder (HOME)
This study looks at a new way to treat depression called tDCS, which uses gentle electrical currents to the brain. It aims to see if using tDCS at home, alongside usual care, helps adults with depression more than usual care alone.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Effects of DLX-001 on PD, Safety, Tolerability, and PK in Participants with MDD
This study is looking at a new medicine called DLX-001 for people with depression. It's a very early-stage study to see if the medicine is safe, how the body handles it, and if people can tolerate it. This helps us learn more about potential new treatments for depression.
Netherlands - recruitingPHASE3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
This study is looking into a new medication called CYB003 for adults with major depression. It aims to see if CYB003 is safe and effective when added to their current antidepressant treatment, compared to a dummy pill.
United States · Australia · Czechia - authorisedTherapeutic exploratory (Phase II)
TMSxDCS: Pharmacologically augmenting transcranial magnetic stimulation for depression
This study is looking at a new way to treat depression, using a combination of two brain stimulation methods and a medication. It aims to see how much people's depression symptoms improve over six weeks after treatment.
Netherlands