- recruitingTherapeutic exploratory (Phase II)
Antimalarial prophylactic efficacy of a weekly dose atovaquone-proguanil
This study tests whether taking a common anti-malaria tablet called Malarone once a week can protect against malaria. Currently, people must take it every day. Researchers will give healthy volunteers weekly medication or a dummy pill, carefully expose them to malaria parasites, and check if the medicine stops infection.
Germany - recruitingHuman Pharmacology (Phase I)- First administration to humans
A study investigating the safety, tolerability, metabolism, and elimination of INE963, a new compound in the treatment of malaria.
This early-stage study is testing a new medicine called INE963 for treating malaria. Researchers want to see how safe the drug is, how well people tolerate it, and how the body breaks it down and removes it. This is the first time INE963 is being tested in humans.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
A Multiple Ascending Dose Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MK-7602 in Healthy Participants
This study is looking at a new medicine called MK-7602 for malaria. It's an early-stage trial to check how safe it is, if people can tolerate it well, and how the body handles the medicine in healthy volunteers. It will help us understand if it's safe to test further for malaria.
Belgium - active not recruitingPHASE3
R21/Matrix-M in African Children Against Clinical Malaria
This study is testing a new malaria vaccine, R21/Matrix-M, in young children in Africa. It aims to see how well it protects them from malaria and if it's safe over a few years, including how many booster shots might be needed.
United Kingdom - active not recruitingPHASE1
A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
This study is testing a new malaria vaccine called RH5.1. We want to see how safe it is and how well it helps the body fight malaria. Two different ways of giving the vaccine are being compared to find the best way.
United Kingdom - active not recruiting
Trajectories and Mechanisms of Recovery From Malaria: An Observational Study
This study in London looks at how people recover from malaria. Researchers want to find out which parts of our biology, including our genes, help us get better. They hope this will lead to new ways to treat malaria alongside current medicines.
United Kingdom - active not recruitingPHASE1, PHASE2
A Study to Assess the Safety and Effectiveness of Two Experimental Malaria Vaccines
This study is testing two new vaccines for malaria, RH5.1 and RH5.2-VLP, to see if they are safe and effective. Researchers will give healthy volunteers the vaccines and then expose some to malaria to see if the vaccines protect them. This is a crucial step towards preventing this serious disease.
United Kingdom