- active not recruiting
DOTATOC PET/CT for Imaging NET Patients
This study looks at a new type of scan called 68Ga-DOTATOC PET/CT for checking on neuroendocrine tumours (NETs) and similar growths. It compares it to a standard scan to see if it’s better at finding these conditions safely.
Canada - active not recruitingPHASE2
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
This study looks at a new drug, palbociclib, combined with standard chemotherapy for children, teenagers, and young adults with certain cancers that have come back or are hard to treat. It aims to find a safe dose and see how well it works.
United States · Brazil · Canada - active not recruitingPHASE4
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors
This study, called HeadStart4, is for children under 10 with certain brain tumours (medulloblastoma and other CNS embryonal tumours). It compares two types of high-dose chemotherapy to see which is more effective at preventing the cancer from coming back or getting worse, and whether it helps children live longer.
United States · Canada · New Zealand - active not recruitingPHASE1
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
This study is testing a new cancer vaccine called SurVaxM for children and young adults with specific types of brain tumours. It aims to train the body's immune system to find and destroy cancer cells that have a special protein.
United States · Canada - active not recruitingPHASE2
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
This study looks at new ways to treat medulloblastoma, a type of brain cancer, in children and young adults. It uses a personalised approach, tailoring treatment based on individual tumour features, aiming for better results with fewer side effects.
United States · Australia · Canada - recruitingPHASE2
DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma
This study looks at a drug called DFMO for young people (0-21 years old) with a brain tumour called medulloblastoma. It's for those whose tumour is high-risk, very high-risk, or has come back after treatment. The aim is to see if DFMO can help prevent the cancer from returning.
United States · Canada - enrolling by invitation
Intraoperatively Observed Site of Origin and Growth Pattern of Medulloblastoma
This study looks at medulloblastoma, a type of brain tumour, in children and adults. Doctors want to understand how it starts and grows by observing it during surgery. They'll compare surgical findings with scans and genetic tests to improve our understanding and treatment.
Austria · Germany · Netherlands - authorisedPhase II and Phase III (Integrated)
An International Prospective Study in Children Older than 3 to 5 Years with Clinically Standard-Risk Medulloblastoma with Low-Risk Biological Profile (PNET 5 MB – LR and PNET 5 MB – WNT-HR), average-risk biological profile (PNET 5 MB -SR), or TP53 mutation, and registry for MB ocurring in the context of genetic predisposition
This study is for children aged 3-18 with a type of brain tumour called medulloblastoma. It looks at different ways to treat the tumour, including various chemotherapy drugs, to find the most effective and safest options for different types of medulloblastoma, aiming to improve chances of recovery and quality of life.
Spain · Netherlands · Czechia