Non-Small Cell Lung Cancer research hub
7 indexed studies · 4 currently recruiting
- ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, First in Human Study of DCC-3116 as Monotherapy and in Combination With RAS/MAPK Pathway Inhibitors in Patients With Advanced or Metastatic Solid Tumors With RAS/MAPK Pathway Mutations
This study is testing a new medicine, DCC-3116, for people with advanced cancers. It will see how safe it is and how well it works, both on its own and when given with other established cancer drugs. This is an early-stage trial to find the best way to use this new treatment.
Germany · Italy · Spain - active not recruitingPHASE1
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
This early-stage study is testing a new drug, MOMA-313, for advanced solid tumours, including prostate, breast, and pancreatic cancers. It aims to find a safe dose and see how it works, either alone or with another drug called Olaparib, in patients whose tumours have a specific genetic weakness.
United States · Spain · United Kingdom - active not recruitingPHASE1, PHASE2
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
This study is testing a new injection, IP-001, after a heat treatment called thermal ablation for certain advanced cancers (bowel, lung, soft tissue sarcoma) that haven't responded to previous treatments. It aims to see if it's safe and effective, potentially offering a new treatment option.
United States · France · Germany - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - recruitingPHASE1, PHASE2
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)
This study is testing a new drug, neladalkib, for advanced cancers that have a specific genetic change called ALK rearrangement. It's looking at how safe the drug is and if it shrinks tumours in people with certain types of lung cancer and other solid tumours.
United States · Australia · Belgium - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruitingPHASE1, PHASE2
A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)
This study is testing a new drug, zidesamtinib, for people with advanced cancer that has a specific genetic change called a ROS1 rearrangement. It will check how safe the drug is and if it can shrink tumours.
United States · Australia · Belgium