Major Depressive Disorder research hub
21 indexed studies · 14 currently recruiting
- recruitingNA
Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults
This study looks at a special type of brain stimulation, called Deep TMS, for people over 60 with both depression and early Alzheimer's or memory problems. It's for those whose depression hasn't improved with usual treatments. We want to see if it's safe and helps with mood.
Canada - active not recruiting
Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)
This study looks at how memory and thinking skills (cognition) change after hip or knee replacement surgery. Researchers want to understand these changes better, identify who might be at higher risk, and find ways to improve recovery. It focuses on changes that might last longer than a few months.
Canada - recruiting
Optical Neuroimaging and Cognition
This study looks at how brain oxygen and energy use change in people with Alzheimer's, Lewy Body Dementia, and Mild Cognitive Impairment. We're using new, gentle scanning methods to better understand these conditions and find ways to help with diagnosis and monitoring.
United Kingdom - active not recruitingNA
Making Memory Better for Seniors With Mild Cognitive Impairment
This study looks into a new type of memory training for older people with mild memory problems. It teaches practical ways to deal with everyday memory issues to see if it can make a real difference and help people manage their daily lives better.
Canada - not yet recruitingNA
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study looks at a new way to help people with balance problems caused by stroke, memory issues, inner ear problems, or Long Covid. It uses a virtual coach at home to guide exercises and improve balance and well-being.
Germany · Greece · Portugal - recruiting
Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
This study looks at a possible link between heart problems and Alzheimer's disease. Researchers will use special scans to see if a protein called amyloid, found in Alzheimer's, also builds up in the heart. This could help diagnose both conditions better.
Germany - recruitingNA
rTMS for Apathy Clinical Trial
This study looks at a brain stimulation treatment called rTMS for people with memory problems and a lack of interest, known as apathy. It aims to see if rTMS can help improve apathy, especially for those already taking medication or not.
Canada - active not recruitingNA
Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression
This study looks into new ways to help older adults experiencing memory problems or depression. It combines brain exercises and a gentle brain stimulation at home to see if it can improve memory and thinking skills, aiming to prevent conditions like Alzheimer's.
Canada - enrolling by invitation
Alzheimer's Disease Neuroimaging Initiative 4
ADNI4 is a research study building on previous work to better understand Alzheimer's disease. It involves looking at memory, brain scans, and blood tests in people with normal memory, mild memory problems, and dementia, to find better ways to detect and treat these conditions.
United States · Canada - not yet recruitingNA
Exploring Feasibility, Acceptability and Impact of Using Neurofeedback with Persons with Mild Cognitive Impairment
This study is looking into new ways to help people with mild memory and thinking problems. It's testing if special 'neurofeedback' methods, which use brain activity, are safe, helpful, and easy to use. The aim is to see if these methods can improve memory, mood, and behaviour.
Canada - recruitingNA
Spatial Memory Training and Cognitive Function
This study looks into how special memory training might help people with mild memory problems. It focuses on improving a part of the brain important for memory, called the hippocampus, with the hope of slowing down memory decline.
Canada - active not recruiting
Cortical Disarray Measurement in Mild Cognitive Impairment and Alzheimer's Disease
This study investigates a new imaging technique, Cortical Disarray Measurement (CDM), to improve the early diagnosis of Alzheimer's disease in people with memory problems. It aims to see if CDM can identify early changes and how these relate to memory over two years, helping us better understand and diagnose Alzheimer’s.
United Kingdom - active not recruiting
Implementing Dementia Care Management Into Routine Care in the Region Siegen-Wittgenstein
This study in Germany is looking at how to make a special type of care, called Dementia Care Management, available to more people with memory problems and their families. It will follow 60 people to see if this care helps them and if it can be easily used in everyday healthcare.
Germany - recruitingNA
Five Lives MED to Improve Cognitive Function in Mild Cognitive Impairment
This study looks at whether a digital app called Five Lives MED can help improve thinking skills in people with Mild Cognitive Impairment (MCI). Participants will use the app for 12 weeks, and their progress will be compared to a group receiving general health information.
France · United Kingdom - recruiting
Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
This study looks for early signs of Alzheimer's disease by examining blood, brain scans, and digital information. It aims to find new ways to spot the disease before it gets worse, especially in people with memory problems or those who are still healthy.
United States · Canada · United Kingdom - active not recruitingNA
You, Me and Nature Pilot Study
This study looks at how nature activities led by a helper might benefit people with memory problems like dementia. It's a small trial to see if a bigger study should be done. Participants include people with memory issues and their caregivers.
United Kingdom - recruiting
Thinking About Memory: How Confident Are You in Your Memory, and Does it Change With Age?
This study explores how older adults think about their own memory abilities. It compares people with and without diagnosed memory problems to understand how confidence in memory changes with age and different memory tasks, which could help with earlier diagnosis of conditions like dementia.
United Kingdom - recruitingNA
Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins on Cognitive Functioning in Older Adults With Mild Cognitive Impairment (COGNIKET-MCI)
This study looks at whether a special nutritional drink, containing fats called ketogenic medium-chain triglycerides and B-vitamins, can help improve thinking and memory in older adults with mild cognitive impairment. Researchers want to see if it makes a difference compared to a dummy drink.
France · Germany · Italy - enrolling by invitation
UK Based Remote Brain Health Clinic (BHC) for Patients With Mild Cognitive Impairment (MCI)
This study looks at a new remote clinic helping people with memory problems understand their condition better. It uses advanced tests, including some for brain fluid, to get a clear diagnosis, all done remotely with checks over time.
United Kingdom - active not recruiting
Longitudinal Early-onset Alzheimer's Disease Study Protocol
This study looks at how early-onset Alzheimer's disease develops over time. It compares people with this condition to those without it, gathering information on memory, brain scans, and other health markers to better understand the disease.
United States · Argentina · Netherlands - recruitingNA
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
This study looks at how gut health, especially methane gas levels, might be linked to Parkinson's disease and memory problems. It also tests if a probiotic can help reduce methane. We want to understand if gut issues affect how these conditions develop and progress.
United Kingdom