Acute Myeloid Leukemia research hub
50 indexed studies · 19 currently recruiting
- recruitingPHASE2
Methods of T Cell Depletion Trial (MoTD)
This study compares different ways to prevent a complication called GvHD after stem cell transplants for various blood cancers. It's looking for the best treatment plan to help patients recover well, using common medicines like Thymoglobulin, Cyclophosphamide, Cyclosporine, Sirolimus, and Mycophenolate Mofetil.
United Kingdom - active not recruitingPHASE3
A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
This study compares two treatments, Iberdomide and Lenalidomide, after a stem cell transplant for multiple myeloma. It aims to find out which one works better at keeping the cancer under control following initial treatment.
United States · Argentina · Australia - authorisedTherapeutic exploratory (Phase II)
Daratumumab in combination with Carfilzomib, Pomalidomide and Dexamethasone (DCPD) in patients with multiple myeloma induced acute renal failure - "Time is Kidney in the Treatment of myeloma Cast nephropathy" The TIKTAC phase II trial (Pilot-study)
This study looks at a new combination of medicines (DCPD) for people with multiple myeloma whose kidneys are not working well. It aims to see if kidney function improves, or if people needing dialysis can stop needing it, after four cycles of treatment.
Austria - authorisedTherapeutic confirmatory (Phase III)
C1071015 - ELRANATAMAB POST TRIAL ACCESS: AN OPEN-LABEL, SINGLE-ARM STUDY FOR PARTICIPANTS WITH MULTIPLE MYELOMA CONTINUING FROM PFIZER-SPONSORED ELRANATAMAB CLINICAL STUDIES
This study is for people with multiple myeloma who are already taking the drug elranatamab as part of another Pfizer study. It helps them keep getting the treatment after their first study finishes. Doctors are watching for any side effects.
France · Spain · Germany - active not recruitingPHASE2
Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom
This study looks at a new drug, Iopofosine I-131, for people with certain B-cell cancers like Waldenstrom, myeloma, or lymphoma, who haven't responded well to other treatments. It aims to see how safe and effective this new approach is.
United States · Australia · Brazil - recruitingPHASE1, PHASE2
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
This study looks at new drug combinations for multiple myeloma that has come back or isn't responding to usual treatment. It checks how safe they are, body reactions, and early signs of how well they might work.
United States · Canada · Norway - active not recruitingPHASE1
A Study Comparing Pre- and Post-Change Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma
This study looks at a new way of making Teclistamab, a medicine for a blood cancer called multiple myeloma. We're checking if the new version works the same inside your body as the old one, to make sure it's safe and effective.
United States · Australia · Canada - recruitingPHASE1, PHASE2
A Study to Assess Adverse Events and Change in Disease Activity of Oral Surzetoclax Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)
This study looks at a new drug, surzetoclax, for multiple myeloma that has come back or not responded to other treatments. It checks how safe it is and how well it works, sometimes alone and sometimes with other medicines. We're looking for adults with this type of myeloma.
United States · Australia · Belgium - active not recruitingPHASE3
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy
This study looks at new treatments for multiple myeloma, a type of blood cancer. It compares a standard treatment plus a new cell therapy called cilta-cel, against the standard treatment alone, for people newly diagnosed who aren't having a stem cell transplant initially.
United States · Argentina · Australia - active not recruitingPHASE1, PHASE2
A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
This study is testing a new drug called CC-220, sometimes on its own and sometimes with other standard cancer medicines, for people with multiple myeloma. It aims to find the right dose, see how safe it is, and if it helps treat the disease.
United States · Australia · Canada - ongoing, recruitingTherapeutic exploratory (Phase II)
KRd consolidation in myeloma patients with a positive PET-CT after standard first line treatment. A phase II study
This study looks at a new treatment combination called KRd for people with multiple myeloma whose scans still show some active cancer after their first treatment. We want to see if KRd can help these patients achieve better results, specifically if their scans become completely clear.
Denmark · Norway - active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation
This study compares a new cell therapy (ide-cel) plus standard maintenance medicine (lenalidomide) against lenalidomide alone for adults with newly diagnosed multiple myeloma. It's for those who haven't fully responded to their initial stem cell transplant.
United States · Australia · Austria - recruitingPHASE1
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
This study looks at a new medicine called etentamig (ABBV-383) for multiple myeloma that has come back or isn't responding to other treatments. It aims to find out about any side effects and how it affects the disease in adults.
United States · Canada · Denmark - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Study Comparing Daratumumab, VELCADE (bortezomib), Lenalidomide, and Dexamethasone (D-VRd) with VELCADE, Lenalidomide, and Dexamethasone (VRd) in Subjects with Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy
This study is looking at a new treatment combination for a type of blood cancer called multiple myeloma, for people who aren't having a stem cell transplant. It compares a new four-drug treatment with a standard three-drug treatment to see if the new one works better.
Spain · Netherlands · France - active not recruitingPHASE3
A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment
This study looks at new drug combinations for multiple myeloma that has come back or isn’t responding to treatment. It compares a drug called talquetamab, alone or with another drug called daratumumab, against a standard treatment of daratumumab, pomalidomide, and dexamethasone.
United States · Belgium · Brazil - recruitingPHASE3
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
This study is testing a new medicine called elranatamab for people with a type of blood cancer called multiple myeloma. It's for those whose cancer has returned after other treatments. We want to see if elranatamab works better than standard medicines.
United States · Argentina · Australia - active not recruitingPHASE3
A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.
This study compares two treatments, Venetoclax plus Dexamethasone, and Pomalidomide plus Dexamethasone, for people with a specific type of multiple myeloma (t(11;14)-positive) that has come back or not responded to previous treatments. It aims to see which treatment works best at preventing the disease from getting worse.
United States · Australia · Canada - active not recruiting
Clinical Decision-making, Prognosis, Quality of Life and Satisfaction in Relapsed/Refractory Multiple Myeloma
This study looks at how health-related quality of life, especially tiredness, affects people with multiple myeloma that has come back or isn't responding to treatment. Researchers want to see if a patient's own reports on their well-being can help predict how long they'll live, independent of other health factors.
Italy · United Kingdom - recruitingPHASE3
Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation
This study looks at new treatments for multiple myeloma, a type of blood cancer. We're testing if teclistamab, alone or with lenalidomide, works better than lenalidomide alone after a stem cell transplant to stop the cancer from coming back.
United States · Argentina · Australia - ongoing, recruitingTherapeutic exploratory (Phase II)
Clinical Trial Using Humanized CART Directed Against BCMA (ARI0002h) in Patients With Relapsed/Refractory Multiple Myeloma to Proteasome Inhibitors, Immunomodulators and Anti-CD38 Antibody
This study is looking into a new treatment for multiple myeloma, a type of blood cancer. It's for adults whose cancer has come back or not responded to previous treatments. The trial aims to see how safe and effective this new cell therapy (called ARI0002h) is.
Spain - ongoing, recruitingTherapeutic exploratory (Phase II)
Continuing Treatment for Subjects Who Have Participated in a Prior Protocol Investigating Elotuzumab
This study looks at how long people with multiple myeloma, a type of blood cancer, continue taking elotuzumab or other treatments after being in an earlier study. It also checks for any side effects experienced.
Romania - active not recruiting
Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)
This study, PREAMBLE, looks at how well approved treatments for multiple myeloma work in everyday medical practice. It includes people newly diagnosed and those whose myeloma has returned or not responded to previous treatments, aiming to understand real-world effectiveness.
United States · Canada · France - recruiting
Examining the clinical effectiveness, feasibility and acceptability of intra-apheresis cycling for peripheral blood stem cell donations
This study looks into whether light exercise, like cycling, during stem cell donation can help people with myeloma. It aims to see if cycling helps collect more cells, making transplants more successful. It's a pilot study taking place in Birmingham.
United Kingdom - recruitingPHASE1, PHASE2
A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma
This study is for people in the UK with multiple myeloma that has come back or not responded to previous treatments. It's testing a new combination of medicines, mezigdomide and elranatamab, to see if they are safe, what dose works best, and how well they might treat the cancer.
United States · Canada · China - recruitingPHASE3
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
This study compares two treatments for newly diagnosed multiple myeloma in adults who can't have a stem cell transplant. It aims to see if a combination including Elranatamab is better than another standard combination at controlling the cancer and improving patients' lives.
United States · Australia · Austria - active not recruitingPHASE3
Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant
This study is for people with newly diagnosed multiple myeloma who have had a stem cell transplant. It compares a new medicine called elranatamab with a standard treatment, lenalidomide, to see which works better at keeping the cancer under control. It will last about five years.
United States · Australia · Austria - active not recruitingPHASE3
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
This study compares two treatments for multiple myeloma that has come back or not responded to previous therapy. It aims to see if a new combination, IberDd, works better and is safer than a standard combination, DVd, for patients in the UK.
United States · Argentina · Australia - active not recruitingPHASE3
A Study of Daratumumab
This study offers ongoing access to specific treatments for people with multiple myeloma or smouldering multiple myeloma who have already benefited from them in previous studies. It helps ensure continued care and collects long-term safety information.
United States · Belgium · Brazil - active not recruitingPHASE3
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
This study is for adults with a type of blood cancer called multiple myeloma that has come back or isn't responding to treatment. It compares a new medicine, etentamig, with existing treatments to see how well they control the cancer.
United States · Australia · Austria - active not recruitingPHASE3
A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
This study compares a new combination treatment, teclistamab with daratumumab (Tec-Dara), against standard treatments for multiple myeloma that has come back or isn't responding well. It aims to see if the new combination works better.
United States · Argentina · Belgium - active not recruitingPHASE3
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide
This study looks at new drug combinations for multiple myeloma that has come back or isn't responding to previous treatments. It compares different ways of combining talquetamab with other medicines to see which works best for people who have already tried certain common myeloma drugs.
United States · Argentina · Australia - recruitingPHASE3
A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma
This study is looking at new drug combinations for people recently diagnosed with a type of blood cancer called multiple myeloma. It compares two new treatments, Teclistamab or Talquetamab, each given with standard drugs, against the usual standard treatment, to see which works best.
United States · Australia · Austria - recruitingPHASE3
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
This study is looking at a new treatment, JNJ-79635322, for multiple myeloma, a type of blood cancer. It compares this new treatment with an existing one (Teclistamab) to see which works better for people whose cancer has returned or hasn't responded to previous treatments.
United States · Australia · Brazil - recruitingPHASE2
A Study to Evaluate Preventive Treatments for GPRC5D-related Oral Events
This study is looking for ways to prevent or reduce changes in taste that can be a side effect of medicines like talquetamab and ramantamig, which are used to treat a type of cancer called multiple myeloma.
United States · Brazil · Netherlands - active not recruitingPHASE2
Carfilzomib/Cyclophosphamide/Dexamethasone with Maintenance Carfilzomib in Multiple Myeloma
This study looks at a new way to treat multiple myeloma, a bone marrow cancer. It combines standard drugs with a new one called Carfilzomib. Researchers want to see if delaying a stem cell transplant works better than having one earlier, by comparing different treatment paths.
United Kingdom - active not recruitingPHASE3
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
This study compares a new cell therapy (Cilta-cel) with standard treatments for multiple myeloma, a type of blood cancer. It's for people whose cancer has returned or isn't responding to their current medicine, especially lenalidomide, to see if the new treatment works better.
United States · Australia · Belgium - recruitingPHASE3
The Role of Ixazomib in Autologous Stem Cell Transplant in Relapsed Myeloma - Myeloma XII (ACCoRd)
This study looks at new ways to treat multiple myeloma that has come back after initial treatment. It compares standard stem cell transplants with a boosted stem cell transplant, and then explores whether ongoing treatment helps keep the cancer away for longer.
United Kingdom - recruitingPHASE3
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
This study looks at new ways to treat multiple myeloma. Researchers are testing a drug called elranatamab, alone and with daratumumab, against a standard treatment. The aim is to find better and safer treatments for people who have tried other medicines.
United States · Argentina · Australia - active not recruitingPHASE3
Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma
This study compares two drug combinations for people with multiple myeloma that has come back or not responded well to previous treatments. It aims to see if a new combination with belantamab mafodotin is better or safer than a standard treatment.
United States · Australia · Brazil - active not recruitingPHASE1
A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma
This study is testing a new medicine called teclistamab, combined with other treatments, for people with multiple myeloma. Scientists want to find the safest and best doses of these combinations to treat the disease effectively.
United States · Australia · Belgium - active not recruitingPHASE1
A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma
This study is looking at a new medicine called talquetamab, combined with other treatments, for people with multiple myeloma. The main goal is to find safe doses and understand how well these combinations work together.
United States · Australia · Belgium - recruitingPHASE1
A Study Evaluating the Safety, Pharmacokinetics, and Activity of Cevostamab in Participants With Relapsed or Refractory Multiple Myeloma
This study looks at a new drug, Cevostamab, for people with multiple myeloma that has come back or not responded to previous treatments. It aims to check its safety, how it moves in the body, and if it helps when given alone or with other medicines.
United States · Australia · Canada - active not recruitingPHASE3
Study of Single Agent Belantamab Mafodotin Versus Pomalidomide Plus Low-dose Dexamethasone (Pom/Dex) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
This study compares a new treatment, Belantamab Mafodotin, with a common combination treatment (Pomalidomide and Dexamethasone) for Multiple Myeloma that has returned or not responded well to past treatments. It aims to see which treatment works better and is safer.
United States · Australia · Belgium - active not recruitingPHASE1
Study of Belantamab Mafodotin Plus Standard of Care (SoC) in Newly Diagnosed Multiple Myeloma
This study looks at a new combination treatment for newly diagnosed multiple myeloma. It combines an existing drug, belantamab mafodotin, with standard treatments (VRd) to see if it's safe and effective, and to find the best dose.
United States · Australia · Canada - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
This study looks at two drugs called dabrafenib and trametinib for various cancers with a specific gene change (BRAF V600). These drugs are already approved for some cancers and researchers want to see if they can help people with other rare cancers or cancers with this same change.
United Kingdom - recruitingPHASE1, PHASE2
A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments
This study looks at a new treatment called belantamab for multiple myeloma, a type of blood cancer. We want to see how safe it is and how well it works, both on its own and when combined with other medicines. It's for people whose myeloma has come back or hasn't responded to previous treatments.
United States · Argentina · Australia - recruitingPHASE1, PHASE2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations
This study is testing a new drug called Etentamig for adults with multiple myeloma, a type of blood cancer. Researchers want to see if it's safe and effective when given alone or with other common treatments to help manage the disease.
United States · Australia · Israel - active not recruitingPHASE3
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
This study compares a new treatment called anitocabtagene autoleucel with standard care for people with multiple myeloma that has come back or not responded to previous treatments. It aims to see if the new treatment works better.
United States · Australia · Austria - recruitingNA
Early Palliative Care for Patients With Multiple Myeloma and Aggressive Lymphoma
This study looks at adding early support care for people with multiple myeloma or aggressive lymphoma. It wants to see if this helps improve their well-being, mood, and how they feel about their care, compared to standard care alone.
Canada - recruitingPHASE1
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)
This study is looking at an experimental treatment for multiple myeloma that has come back or hasn't responded to other treatments. It combines two medicines, elranatamab and iberdomide, to see how safe and effective they are together in adults.
United States · Australia · Canada