- ongoing, recruitingTherapeutic confirmatory (Phase III)
A Single Arm, Open Label Multicentre Extension Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients with Multiple Sclerosis Previously Enrolled in A F. Hoffmann-La Roche Sponsored Ocrelizumab Phase IIIb/IV Clinical Trial
This study looks at how well a medicine called ocrelizumab works and if it's safe for people with multiple sclerosis (MS). It's for patients who have already been in similar studies with the same medicine.
Hungary · Norway · Croatia - recruiting
Escalation vs. Induction Therapy Strategy in Patients With Early-Onset MS After Age 50
This study compares different ways to treat Multiple Sclerosis (MS) in people who develop the condition after age 50. Researchers are looking at whether starting with stronger treatments or gradually increasing treatment strength makes a difference in preventing flare-ups and complications.
France - recruitingPhase II
A preliminary study investigating if muscle stimulation as an exercise therapy for people with multiple sclerosis helps strengthen muscles, improves walking, helps with tiredness, and reduces spasms
This study looks at whether a home-based muscle stimulation device can help people with MS improve walking, muscle strength, and reduce tiredness and spasms. It's a first step to see if a larger study is a good idea.
United Kingdom · England - active not recruitingPHASE3
Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis
This study looks at two new medicines, ofatumumab and siponimod, for children and teenagers aged 10-17 with multiple sclerosis (MS). It compares them to a medicine called fingolimod to see if they are safe and work well.
United States · Argentina · Australia - recruiting
Pregnancy Cohort in Multiple Sclerosis (MS)
This study looks at how pregnancy affects women with multiple sclerosis (MS) or clinically isolated syndrome (CIS) and how their pregnancies turn out. Researchers will collect information during and after pregnancy to better understand MS.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Investigate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of Ascending Intravenous Doses of Glofitamab, Administered after Ocrelizumab Pretreatment, in Patients with Multiple Sclerosis
This study is looking at a new treatment called glofitamab for multiple sclerosis (MS). Researchers want to see if it's safe, how well the body handles it, and how it works after patients have taken another medicine called ocrelizumab.
Croatia · Czechia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Investigate Single Ascending Doses of Ocrelizumab for Safety and Side Effects, How The Body Handles It Over A Period of Time, How The Body Notices and Reacts To It, And Its Effect On The Body When Given As A Subcutaneous Injection In Patients With Multiple Sclerosis
This study is testing a new injection of a medicine called ocrelizumab for people with Multiple Sclerosis (MS). It's looking at whether different doses are safe, how the body handles the medicine, and what effects it has. It's a very early-stage study.
Belgium · France · Czechia - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study to Investigate the Pharmacokinetics, Pharmacodynamics, Safety and Radiological and Clinical Effects of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab in Patients with Multiple Sclerosis
This study is looking at a new way to give a medicine called Ocrevus to people with Multiple Sclerosis (MS). Instead of an IV drip, it might be given as a shot under the skin. We want to see if it works just as well and is safe.
Spain · Czechia · Poland