- recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of E2086 in Adults with Narcolepsy
This clinical trial is testing a new medicine called E2086 for adults with narcolepsy. Researchers want to see if E2086 helps people stay awake during the day and reduces sudden muscle weakness. The study also checks the safety of the medicine over four weeks of daily treatment.
Belgium · Italy · Spain - recruitingTherapeutic confirmatory (Phase III)
Double blind, multicentre, randomized, placebo-controlled trial to evaluate safety and efficacy of pitolisant in children from 6 to less than 18 years with narcolepsy with/without cataplexy, followed by a prolonged open-label period
This study is looking at a medicine called pitolisant for children aged 6 to 17 with narcolepsy. Researchers want to see if it makes their daytime sleepiness and muscle weakness (cataplexy) better and if it's safe to use.
Italy · France - recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-6552 in healthy adults (MK-6552-002)
This study is testing a new medicine, MK-6552, in healthy adults. It's an early-stage study to see how the medicine works in the body and if it's safe. The goal is to learn more about this potential treatment for narcolepsy.
Belgium - recruitingTherapeutic confirmatory (Phase III)
An Open-Label, Multicenter Switch Study Evaluating Changes in Blood Pressure in Participants With Narcolepsy Switching From High-Sodium Oxybate to XYWAV
This study looks at how a new medicine, JZP258 (also called XYWAV), affects blood pressure in people with narcolepsy. It compares XYWAV to another similar narcolepsy medicine to see if it lowers blood pressure.
Czechia · France · Belgium - recruiting
Mainz Register of Patients With Sleep Disorders
This study in Mainz, Germany, is looking at how different sleep disorders, like narcolepsy and insomnia, affect people's lives over time. It's collecting information about their symptoms, treatments, and how they feel about their quality of life to better understand these conditions.
Germany - authorisedPhase II and Phase III (Integrated)
CIRAANO: Multimodal exploration (including radiopharmaceuticals Amyvid® and Tauvid®) of theater actors, memory athletes, and patients with various memory pathologies: evaluation of mnesic strategies and their cerebral substrates, and contribution to the treatment of memory pathologies.
This study looks at memory in different groups, including actors, memory athletes, and people with memory problems like Alzheimer's. It uses special brain scans to understand how different memory strategies work in the brain and how this might help treat memory conditions.
France