- active not recruitingPHASE3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
This study is testing a new medication called donanemab for people in the early stages of Alzheimer's disease. Researchers want to see if it's safe and helps improve or slow memory and thinking problems. It's a key step in understanding potential new treatments for this condition.
Argentina · Australia · China - recruitingPHASE2
Efficacy and Safety of Oral Midazolam Used for the Delivery of Care in Elderly Patient With Neurocognitive Disorders and Refusing Care.
This study looks at whether a special liquid form of midazolam given by mouth can help older patients with memory problems who refuse care. The goal is to make healthcare easier and more comfortable for them, comparing it to a dummy medicine.
France - recruiting
Talk-to-Jo" Intelligent Digital Health Companion, Neurocognitive Disorders and Dyads
This study is testing a digital helper called "Talk-to-Jo" for older people with memory problems and their carers. It asks about memory and feelings to give helpful tips. The goal is to see if this technology can support people at home and reduce stress for carers.
Canada - recruitingNA
Neurocognitive Disorders After Major Surgery in Elderly
This study looks at whether a special way of giving anaesthesia to people over 70 during major surgery can reduce memory and thinking problems afterwards. It compares a brain-wave guided method with standard care.
Canada - recruitingPHASE4
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
This study looks at whether a medicine called Dexmedetomidine can help prevent memory problems and confusion after heart surgery. Researchers want to see if it improves recovery and reduces how long people stay in hospital.
Canada - recruitingNA
rTMS for Apathy Clinical Trial
This study looks at a brain stimulation treatment called rTMS for people with memory problems and a lack of interest, known as apathy. It aims to see if rTMS can help improve apathy, especially for those already taking medication or not.
Canada - recruiting
Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders
This study looks at the 'gooeyness' (viscosity) of blood vessel walls in the neck. We want to see if this is linked to memory problems like Alzheimer's or vascular dementia, or if it changes as we age. Understanding this might help us learn more about these conditions.
France - recruiting
Biobank and Brain Health in Bordeaux.
This study, called "B cube," looks at how our brains change as we get older, especially from age 55. Researchers want to understand why some people's memories and thinking skills decline and how to prevent it. They are studying 2000 people in Bordeaux, France, focusing on things like diet and overall health.
France - active not recruitingPHASE3
A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
This study is looking at different ways of giving a medicine called donanemab for early Alzheimer's disease. Researchers want to see how different doses affect side effects and which patients might be more likely to experience them. It's for adults aged 60-85.
United States · United Kingdom - recruiting
CONCEPTT Kids International Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes
This study looks at how children of mothers with Type 1 diabetes are developing. It aims to understand how their brains are growing and functioning, especially regarding things like attention and social skills.
Canada · Spain · United Kingdom