- ongoing, recruitingPhase III and phase IV (Integrated)
L-NAC for reversal of opioid-induced respiratory depression
This study is looking at a medicine called L-NAC to see if it can help people who have breathing problems after receiving strong pain medication like fentanyl. It aims to find out if L-NAC can help them breathe more easily and safely. Participants will be healthy volunteers.
Netherlands - ongoing, recruitingTherapeutic confirmatory (Phase III)
Fentanyl effect on ventilatory pattern under sham postsurgical conditions – an exploratory study in healthy men and women – the FAME study
This study, called FAME, is looking at how a pain medicine called fentanyl affects breathing in healthy adults. Researchers want to understand its effects better to improve safety, especially after operations. It's a key step in understanding how this medicine works.
Netherlands - ongoing, recruitingPhase III and phase IV (Integrated)
The effects of the manipulation of 5-HT, DA and NA on exercise-induced fatigue and brain activation
This study looks at how certain brain chemicals affect tiredness during exercise. Researchers want to understand how these chemicals change what people feel and how their brain works when they get tired from physical activity.
Belgium - ongoing, recruitingTherapeutic use (Phase IV)
The role of serotonin in learning and decision-making: a behavioural study
This study is looking at how a brain chemical called serotonin might affect how we learn and make decisions. Participants will take either a common antidepressant medication (escitalopram) or a dummy pill, and then complete tasks to see how this affects their accuracy and speed.
Netherlands