- ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A RANDOMIZED, DOUBLE-BLIND, THREE-PART, TWO-PERIOD, TWO-SEQUENCE, SINGLE-DOSE, CROSS-OVER STUDY TO COMPARE THE PHARMACOKINETICS (PK), SAFETY AND IMMUNOGENICITY PROFILE OF MB04 (PROPOSED ETANERCEPT BIOSIMILAR), EU-SOURCED ENBREL® AND US-LICENSED ENBREL® IN HEALTHY MALE VOLUNTEERS.
This study compares a new version of a common medicine (MB04) to the original medicine (Enbrel) in healthy men. It checks how the body handles the medicine and for any side effects, to make sure the new version works the same way.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Phase I, Randomized, Partial Double-blind, Single dose, 3-Way Cross-over Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, and Formoterol for BGF MDI HFO Compared with BGF MDI HFA Using an AeroChamber Plus Flow-Vu Spacer and to Compare the Lung Exposure of BGF MDI HFO with a Spacer to BGF MDI HFO without a Spacer
This study looks at a new inhaler for breathing problems. We're testing how much of the medicine reaches the lungs when used with or without a spacer, compared to a current inhaler. It's for healthy adults to make sure the medicine works as expected.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Randomized, Open Label, Single-Dose Crossover Study to Assess the Relative Bioavailability, Food Effect, and Safety of Capsule Formulations of INF904.
This study is looking at a new medicine called INF904. We want to see how well different forms of this medicine get into the body and if food changes that. It's for healthy adults and is an early-stage study to check safety.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A trial to learn how much budesonide, glycopyrronium, and formoterol fumarate (BGF) gets into and moves throughout the body when it is taken with hydrofluoroolefin (HFO) compared to when it is taken with hydrofluoroalkane (HFA) in healthy adults
This study is looking at how a new inhaler works. It compares two ways of delivering the same medicine to healthy adults: one using a new propellant (HFO) and another using a common propellant (HFA). We want to see how the medicine enters and moves through the body.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A SINGLE-CENTER, OPEN-LABEL, TWO-PERIOD STUDY TO INVESTIGATE THE EFFECT OF MULTIPLE DOSE ITRACONAZOLE, A STRONG CYP3A INHIBITOR, ON THE PHARMACOKINETICS OF A SINGLE 30 MG DOSE OF RO7269162 IN HEALTHY PARTICIPANTS
This study looks at how a new medicine, RO7269162, works in the body when taken with another medicine, Itraconazole. It needs healthy volunteers to understand how these medicines interact with each other. This is an early-stage study to help us learn more about the new medicine.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to find out the safety, tolerability and interaction of drug with body (including the effect of Itraconazole on RO7268489) and also what the body does to RO7268489 after oral intake by healthy participants
This study is looking at a new medicine called RO7268489. We want to see how safe it is, how well people tolerate it, and what happens to the medicine in the body after someone takes it by mouth. We also want to see if another medicine, Itraconazole, changes how RO7268489 works.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess the effect of gemfibrozil, itraconazole and phenytoin on levels of IPN60250 in the blood of healthy adult participant.
This study is looking at how certain medicines (gemfibrozil, itraconazole, and phenytoin) affect the levels of a new drug called IPN60250 in the blood. Healthy adults over 18 can take part. It's an early-stage study to understand how drugs interact.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to assess the effects of efgartigimod on emasiprubart in healthy adult participants
This study is looking at how two new medicines, efgartigimod and emasiprubart, work in healthy adults. It's an early-stage study to understand how these medicines behave in the body, not to treat any specific illness yet.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Neurogenic inflammation upon AITC-induced TRPA1 activation
This study looks at how a natural chemical, similar to what makes mustard spicy, affects nerves in healthy men. Researchers want to understand how our bodies react to certain sensations. This helps scientists learn more about how our nerves work and react to irritation.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A trial to learn about how multiple doses of itraconazole change how AZD5004 moves throughout the body over time in healthy adults and how multiple doses of AZD5004 change how ethinyl estradiol and levonorgestrel move throughout the body overtime in healthy female adults
This study looks at how a new drug, AZD5004, interacts with a common anti-fungal medicine (itraconazole) and with common birth control pills (ethinyl estradiol and levonorgestrel). It's for healthy adults and helps us understand how these medicines work together in the body.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Learn How Safe Different Doses of NTS-521 are, What the Amount of NTS-521 in the Body is Over a Period of Time, and What the Effects of NTS-521 on the Body and the Body on NTS-521 are in Adult and Elderly People Receiving Single and Multiple Doses of NTS-521 via an Infusion Directly into a Vein
This study is the first time a new medicine, NTS-521, will be given to people. It aims to check what doses are safe, how much of the medicine stays in the body over time, and how the body reacts to it when given through a drip.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study comparing different RO7269162 capsules and investigating the effect of food on the uptake, breakdown, and elimination of RO7269162 in Healthy Participants
This study is testing a new medicine, RO7269162, in healthy people. We want to see how different forms of the capsule work in the body and if food changes how the body uses the medicine. This helps us understand the best way to give the medicine in the future.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study investigating the safety, absorption, and elimination of RO7795081, a new compound that may potentially be used in the treatment of type 2 diabetes and weight control
This study is looking at a new medicine called RO7795081. It's hoped this medicine might help people with type 2 diabetes and those trying to manage their weight. Researchers want to see if it's safe, how the body uses it, and how it leaves the body.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Track How the Healthy Male Participants Handles the New Oral Drug RO7795081 for Weight Management and Diabetes
This study is testing a new oral drug, RO7795081, in healthy men. It's a very early stage trial looking at how their bodies handle the drug, which is being developed to help with weight and diabetes.
Netherlands