- completed
Introducing a non-endoscopic diagnostic test into the clinical pathway to identify high-risk patients with Barrett's oesophagus
This study tests a quick 'sponge on a string' check called Cytosponge. It helps doctors find Barrett's oesophagus in people with long-term heartburn. Barrett's can sometimes lead to food pipe cancer. Swallowing this small capsule at your GP surgery offers a faster, simpler alternative to a hospital camera test.
United Kingdom · England - recruitingPhase II and Phase III (Integrated)
Nivolumab during active surveillance after neoadjuvant chemoradiation for esophageal cancer: SANO-3 study
This study looks at a new drug called nivolumab for people with oesophageal cancer who have had previous treatment. It aims to see if nivolumab can help stop the cancer from coming back after surgery and chemotherapy/radiotherapy, by carefully monitoring patients for any return of the disease.
Netherlands - recruiting
A clinical trial to investigate if proton beam therapy with chemotherapy given before surgery for patients with oesophageal cancer that has spread to the surrounding tissues, significantly reduces the severe side effects to the heart and lungs and allows immunotherapy to be started sooner after surgery when compared with standard radiotherapy and chemotherapy before surgery, and whether this delivers value to the NHS and patients
This trial looks at using proton beam therapy instead of standard radiotherapy before surgery for cancer of the food pipe (oesophagus). Researchers want to find out if this targeted treatment reduces side effects to the heart and lungs, helping patients recover more quickly so they can start further treatments sooner.
United Kingdom · England · Wales - recruiting
Evaluation of Seismocardiography(SCG) for Assessing Fitness and Predicting Outcomes in Oesophageal Cancer Surgery
This study looks at a new, quick device called Seismofit. It measures your fitness using heart vibrations. We want to see if it can help predict how well patients with oesophageal cancer will recover after surgery and treatment, and compare it to existing fitness tests.
United Kingdom - recruiting
Volatile Organic Compounds as Breath Biomarkers in Squamous Oesophageal Neoplasms
This study is looking into a new breath test for a type of food pipe cancer (oesophageal cancer). The aim is to find a simple, non-invasive way to detect the cancer early, which could greatly improve treatment success.
United Kingdom - not yet recruitingNA
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
This study looks at using a special type of electrical muscle stimulation (like gentle zaps) on the whole body, combined with healthy eating advice. It's for people with certain tummy and bowel cancers to see if it helps build muscle and improve energy better than exercise alone.
Germany - recruitingPHASE1
A Phase 1 First-In-Human Study of the Anti-CD73 IPH5301 Alone or in Combination With Chemotherapy and Trastuzumab in Patients With Advanced Solid Tumors
This study is testing a new drug called IPH5301 for advanced cancers like breast, stomach, and lung. It's a first-time-in-human study, meaning it's the very first time this drug is being given to people. Researchers want to find a safe dose, either alone or with other treatments.
France - recruiting
Cancer Loyalty Card Study 2 (CLOCS-2)
This study looks at shopping habits using loyalty card data from Tesco or Boots to see if certain purchases might hint at cancer earlier. It aims to help doctors diagnose pancreatic, bowel, oesophageal, stomach, liver, bladder, womb, vulval, and ovarian cancers sooner.
United Kingdom - recruitingNA
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
This study looks for early signs of stomach and gullet cancer using a simple breath test. Researchers hope to make this test more accurate by giving people a special drink to help show up certain chemicals in their breath that are linked to cancer.
United Kingdom - active not recruitingPHASE2
Do Changes in ctDNA Predict Response for Patients With Oesophageal Cancer Receiving Durvalumab
This study looks at a new way to quickly see if a cancer treatment called durvalumab is working for people with oesophageal cancer. We're testing if changes in a blood marker (ctDNA) can tell us sooner than scans if the treatment is helping.
United Kingdom - recruiting
Cardiopulmonary Toxicity of Thoracic Radiotherapy
This study looks at how radiotherapy for lung and oesophageal cancer might affect your heart and lungs. We want to see if a condition called pulmonary hypertension, which affects blood flow in the lungs, is a common side effect so we can improve care.
Belgium · Netherlands · United Kingdom - active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom - recruiting
Understanding the Variation of Modern Endoscopic Ultrasound Use in Patients With Oesophageal Cancer (VALUE)
This study, called VALUE, looks at how using a special camera test (endoscopic ultrasound or EUS) affects treatment decisions for people with oesophageal cancer. Researchers want to see how often this test changes the plan for patients who could potentially be cured.
United Kingdom - active not recruiting
Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors
This study looks at how gut germs affect long-term health in people who've had gullet cancer surgery. We're hoping to find new ways to spot and treat gut problems to improve their quality of life after cancer.
United Kingdom - recruiting
REVOLUTION Surgery (REVOLUTION Surgery)
This study looks into why some cancer patients lose weight and muscle, a condition called cachexia. It aims to understand this problem better by gathering information from patients undergoing surgery for certain cancers and comparing it with people having surgery for non-cancer conditions.
United Kingdom