- recruitingTherapeutic exploratory (Phase II)
A randomized, double-blind parallel group study to investigate propofol injection pain compared with placebo in healthy adult male and female participants. (PropPain)
Propofol is a common anaesthetic that helps people sleep during surgery, but it can cause stinging when injected. This study tests how much discomfort a propofol injection causes compared to a harmless saltwater injection in healthy adults. Researchers hope the findings will help make future injections more comfortable.
Norway - recruitingHuman Pharmacology (Phase I)- Other
A study to determine if BHV-2100 and BHV-7000 are effective, safe, and tolerable as a pain medication in healthy male participants
This study is looking into two new pain medications, BHV-2100 and BHV-7000, to see how well they work and if they are safe for healthy men. Researchers want to understand their effects to help develop better ways to manage pain.
Germany - recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-5661 and placebo in healthy people (MK-5661-006)
This study is looking into a new medicine called MK-5661 for pain. It's a very early study to see how safe the medicine is in healthy men and how their bodies handle it. Researchers will also compare it to a dummy pill.
Belgium - recruitingHuman Pharmacology (Phase I)- Other
A Trial Investigating the pain-relieving properties of Lu AG06474 in Healthy Adult Participants
This study is looking into a new medication called Lu AG06474 to see if it can help with pain. It's an early-stage study involving healthy adults to understand how the drug works and if it's safe.
Netherlands - recruitingTherapeutic exploratory (Phase II)
Evaluation of quantitative sensory testing (QST) using subcutaneous administration of single escalating doses of halneuron® (tetrodotoxin (TTX)) for injection in healthy volunteers
This study is testing a new medicine, HALNEURON, which contains tetrodotoxin (TTX), in healthy volunteers. It will look at how different doses affect how people feel sensations like touch or temperature, to see if it could help with pain in the future.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
MK-4318 CIDF Target Engagement Study
This early-stage study is looking at a new medicine called MK-4318 for pain. It's testing how the medicine affects the body in healthy men to see if it works as expected. This helps researchers understand if it could be a good treatment for pain in the future.
Belgium - recruitingTherapeutic use (Phase IV)
A prospective, randomized, double-blind, controlled trial on the application of a 10%-lidocain spray prior to the insertion of a peripheral intra-venous catheter in female adults
This study looks at whether a numbing spray can reduce pain when putting in an IV drip (a small tube in your vein) in adult women. We're hoping to find a simple way to make this common procedure less uncomfortable.
Austria - recruitingTherapeutic exploratory (Phase II)
Open-label, prospective study to assess the safety, tolerability, analgesic effect and feasibility of IN SUF/KET in pediatric patients with moderate or severe pain, in an acute care setting
This study is looking at a new nasal spray medicine for children and young people aged 1 to 18 years who are in hospital and have moderate to severe pain. We want to see how well it works, how safe it is, and if it's easy to use.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A Multiple-Ascending-Dose Study of MK-4318 in Healthy Participants
This study is testing a new medicine called MK-4318 in healthy people. The main goal is to see how safe the medicine is and how the body handles different doses of it. Researchers hope this medicine could one day help with pain.
Belgium - recruiting
Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)
This study looks at how medical cannabis helps people in the UK with pain, sleep problems, anxiety, depression, or epilepsy. We want to see how well it works over time using patient feedback.
Canada - active not recruiting
SPRINT: Signature for Pain Recovery IN Teens
The SPRINT study wants to understand why some teenagers with long-lasting pain get better, while others don't. Researchers hope to find important clues to create better treatments for young people struggling with ongoing pain.
United States · Canada · Spain - recruitingNA
Effect of Erector Spinae (ESP) Block on Opioid Reduction and Enhanced Recovery After Posterior Cervical Spine Surgery
This study is looking into a new way to help manage pain after neck surgery using a special injection called an Erector Spinae (ESP) block. We want to see if this injection can reduce the need for strong painkillers and help patients recover faster.
Canada - not yet recruitingNA
Virtual Reality for Pain and Anxiety in Pediatric Dental Treatment
This study looks at whether using a special virtual reality (VR) headset can help children aged 6-12 feel less pain and worry during dental treatment. It compares VR to standard ways dentists already use to help children feel calm.
Canada - active not recruitingNA
Assessment of the Effects of Maela Connected Follow-up on Well-being and Pain After Lumbar Spine Surgery
This study looks at how a special app could help people recover from back surgery. We want to see if using the app after lumbar spine surgery helps with pain and makes life better compared to standard care. Only adults aged 18 to 60 having their first back surgery can take part.
France - recruitingNA
Effectiveness of Musicotherapy in Reducing Pain Induced by Leg Ulcer Care
This study looks at whether listening to music during wound cleaning (debridement) can help reduce pain for people with leg ulcers. It aims to see if a special music therapy method can make this common, sometimes painful, procedure more comfortable.
France - recruitingNA
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
This study looks into why some people get migraines, especially those with other health conditions like autoimmune diseases. Researchers are examining how chemicals in the body, called cytokines, and special immune cells, called Treg cells, might be linked to migraine pain. They hope to better understand migraine causes.
France - recruitingPHASE2
Epsom Salt Compresses to Relieve Perineal for Postpartum Care: a Clinical Trial
This study looks at whether Epsom salt compresses can help reduce pain after childbirth. Researchers compare compresses with Epsom salt to compresses with just water. The goal is to find a simple way to ease discomfort for new mothers.
Canada - recruitingNA
Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.
This study looks at a new way to reduce pain and improve recovery for military personnel with leg injuries. It uses a technique called blood flow restriction (BFR) during exercise. The aim is to find the best way to use BFR to help patients get back to their duties sooner.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
A randomized, double-blind crossover study to investigate the analgesic efficacy of the bradykinin (B2) antagonist icatibant for propofol injection pain in healthy adult participants.
This study is looking for healthy adults to test a new medicine idea, icatibant, to see if it can reduce the stinging pain sometimes felt when having an injection of propofol, a medicine used for sleep during medical procedures.
Norway - recruitingNA
Auricular Acupuncture in Patients With Advanced Cancer: a Randomized Clinical Trial.
This study is looking at how a type of ear acupuncture, called ear acupressure, might help people with advanced cancer. It aims to see if it can improve how they feel overall, and if it helps with common problems like tiredness, pain, feeling down, and sleep issues.
Germany - authorisedTherapeutic use (Phase IV)
MetAddon: Methadone as co-analgesic for patients with metastatic bone pain: a double-blind randomized controlled trial
This study is looking at how well a medicine called methadone works alongside usual pain relief for people with cancer pain that has spread to their bones. It compares methadone with morphine to see which is better at reducing pain.
Netherlands - recruiting
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
This study looks at how well Boston Scientific nerve stimulation devices work in real life for people with pain. It checks their long-term effects and how they perform. The main goal is to understand how these treatments help patients over time.
United States · Argentina · Australia - recruitingNA
Spinal Cord Stimulation for Chronic Abdominal Pain Patients
This study looks at a new way to treat ongoing tummy pain using a small device that sends gentle electrical signals to your spinal cord. It's designed not to cause tingling, hoping to give better relief for pain that hasn't responded to other treatments.
United Kingdom - not yet recruitingNA
Is Low-load Resistance Training With Blood Flow Restriction More Effective Than Traditional Rehabilitation of Military Personnel With Lower Limb Injuries
This study looks at a new way to reduce pain and improve recovery for UK military personnel with lower body injuries. It's comparing a special exercise method using blood flow restriction (BFR) with standard rehabilitation to see which works best and why. The goal is to help soldiers get back to full fitness.
United Kingdom - active not recruiting
Virtual Reality for Advanced Cancer Pain
This study aims to develop and test a virtual reality (VR) program to help people with advanced cancer manage their pain. Researchers will work with patients to create a VR experience that is effective, easy to use, and enjoyable, hoping it could offer a new way to cope with pain.
United Kingdom - authorisedHuman Pharmacology (Phase I)- Other
A clinical study of MK-5661 in healthy people (MK-5661-007)
This study is testing a new medicine, MK-5661, in healthy adult volunteers to understand how it works in the body and if it's safe. It's an early-stage study, meaning it's one of the first times this medicine is given to people. The aim is to help find new ways to treat pain.
Belgium - recruitingNA
Virtual Reality in Elective Caesarean Births Study (VREC)
This study looks at whether watching a special virtual reality film can help reduce anxiety for women having an planned C-section at Royal United Hospital. It compares this film to the usual information given to see if it makes a difference.
United Kingdom