- recruitingPHASE3
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
This study is looking at a new drug, daraxonrasib, for people with pancreatic cancer that has spread. It compares daraxonrasib alone, or with standard chemotherapy (gemcitabine and nab-paclitaxel), against standard chemotherapy by itself. The aim is to see if the new treatments can help people live longer and stop the cancer from growing.
United States · Australia · Austria - active not recruitingPHASE1, PHASE2
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
This study is testing a new cancer medicine, GEN1042, both by itself and with other treatments. It's for people with certain advanced solid tumours where standard treatments haven't worked or aren't available. The main goals are to check its safety and see how well it fights cancer.
United States · Denmark · France - recruitingPhase I and Phase II (Integrated)- Other
A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus–Pancreatic Cancer)
This study is testing different combinations of new drug treatments for people with advanced pancreatic cancer. Doctors want to see how well these combinations shrink tumours and if they are safe to use.
Spain - recruiting
Breath Research Narrow Validation for Gastrointestinal Cancer Detection
This study is developing a simple breath test to help find common gut cancers earlier, like those in the food pipe, stomach, pancreas, liver, and bowel. Finding cancer early means better treatment options. We're testing if breathing into a special device can quickly spot these cancers by detecting tiny molecules in your breath.
United Kingdom - recruitingPHASE3
Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
This study is testing a new medicine, atebimetinib, alongside standard chemotherapy for pancreatic cancer that has spread. We want to see if this combination works better and is safe for patients who haven't had treatment before.
United States · Australia · Georgia - recruitingPHASE3
Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )
This study is testing a new drug called zoldonrasib, combined with standard chemotherapy, for people with pancreatic cancer that has spread. It compares this combination to chemotherapy alone, to see if it helps people live longer or stops the cancer from growing for longer. It focuses on a specific type of cancer gene.
United States · United Kingdom - active not recruitingPHASE1, PHASE2
Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)
This study looks at a new treatment called M9140 for different advanced cancers like stomach, lung, and pancreatic cancer. It aims to see if it's safe and effective for patients whose cancers have a specific marker called CEACAM5.
United States · Australia · Austria - recruitingNA
Early Feasibility Clinical Investigation to Assess YntraDose™ as a Neoadjuvant Treatment for LA-PDAC
This study investigates a new radiotherapy for advanced pancreatic cancer that can't be surgically removed. It involves a single injection of a radioactive implant directly into the tumour, alongside standard chemotherapy. Researchers will assess safety, effectiveness, and impact on quality of life.
Italy · United Kingdom