- recruitingHuman Pharmacology (Phase I)- First administration to humans
Phase I single-blind clinical trial to evaluate the safety and local immune activation of a toll-like receptor 5 agonist (FLAMOD) administered by aerosol
This early-stage study is looking at a new medicine called FLAMOD for pneumonia. It's given through an inhaler and aims to check if it's safe and how it affects the body's natural defences in the lungs for the first time in people.
France - completedPhase IV
PREVENTING PNEUMOcoccal disease through vaccination: PREVENTING PNEUMO 2
This UK study tests how well two common pneumonia vaccines stop bacteria from settling in the nose. Healthy adults aged 18 to 50 receive either a real vaccine or a dummy saltwater injection. The goal is to help scientists design better, more effective vaccines against serious chest infections in the future.
United Kingdom · England - completedNot Applicable
Inhale work package 3 – rapid versus standard testing to diagnose lung infections in intensive care, including COVID-19 observational sub-study
Severely ill hospital patients can quickly develop dangerous chest infections like pneumonia. Standard lab tests take two to three days to find the cause, so doctors often use general antibiotics. This UK study tests a rapid machine that delivers results in eight hours, helping doctors pick the right medicine sooner.
United Kingdom · England - not yet recruiting
Hierarchy of Effects of Laboratory Markers and Their Interaction With Comorbidity Concerning Outcome and Personalized Treatment of Trauma Patients in Emergency Care and Rehabilitation
This study looks at how blood tests and health conditions affect people recovering from serious bone breaks. We want to find out early which patients might have problems after injury so doctors can give them tailored care.
Germany - active not recruitingNA
Aiding COPD and CHF Ultrasound-guided Management Through ENhanced Point Of Care UltraSound
This study looks at whether using a special ultrasound and software called PRESUNA can help people with COPD or heart failure manage their health better at home. It compares this new approach to the usual care provided by a home hospital team.
Canada - recruiting
Pediatric and Ambulatory Research in Infectious Diseases
This study is setting up a network of children's doctors in France to better track common infections like colds and tummy bugs. They are using special training and computer tools to gather information and learn more about these illnesses in children under 16.
France - recruiting
Study of Hospitalised Patients With Acute Respiratory Conditions
This study looks at how people recover after being in hospital with a serious breathing problem. It aims to find out what helps people get better, what might lead to readmission, and how long they stay in hospital. We’ll also compare them to outpatients and healthy people.
United Kingdom - recruitingPHASE3
Randomised Evaluation of COVID-19 Therapy
The RECOVERY trial looks at treatments for serious lung infections like pneumonia, including COVID-19. It helps doctors find the best ways to help hospitalised patients get better and reduce their risk of dying. Many treatments have been tested, and some have been found to be very helpful.
Belgium · Estonia · France - not yet recruiting
Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis
This study looks at how antibiotics work differently in people with severe pneumonia and sepsis. We want to understand if different immune system reactions affect antibiotic levels, aiming to improve treatment and fight antibiotic resistance.
United Kingdom - not yet recruiting
Development of the Drug and Alcohol Respiratory Health Test
This study is creating a simple test to check lung health in adults who use certain substances. Many people with substance use disorder have breathing problems that often go unnoticed. This new test aims to find these issues early so people can get the right help.
United Kingdom - recruiting
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
This study looks for early signs of lung cancer and other lung problems by testing breath. We're trying to find a simple, quick way to help doctors decide who needs more tests, especially for people with ongoing breathing issues.
United Kingdom - not yet recruiting
The AcCREDiT 2 Study
The AcCREDiT 2 study looks at how to quickly identify infections in people with breathing problems, like pneumonia or flare-ups of conditions like COPD. It aims to improve how we test for these infections and make sure patients get the right treatment faster.
United Kingdom