Progressive supranuclear palsy research hub
8 indexed studies · 5 currently recruiting
- completedPhase II
Noradrenaline treatment of apathy and impulsivity in participants with Progressive Supranuclear Palsy syndromes
This UK clinical trial is testing a medicine called atomoxetine for people with Progressive Supranuclear Palsy (PSP). Researchers want to see if boosting a natural brain chemical can safely improve motivation, attention, and impulsive behaviours. All participants receive both the medicine and a dummy pill at different times.
United Kingdom · England · Scotland - recruitingTherapeutic confirmatory (Phase III)
A Phase 2b/3 Study of Safety and Efficacy of AMX0035 in Progressive Supranuclear Palsy (ORION)
This study, called ORION, is testing a new drug called AMX0035 for Progressive Supranuclear Palsy (PSP). Researchers want to see if the drug is safe and helps slow down the disease's progression. It's a late-stage trial, hoping to show clear benefits.
Bulgaria · Austria · Netherlands - recruiting
Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases
This study looks at how swallowing and voice box problems affect people with conditions like Parkinson's and Motor Neuron Disease. Researchers will observe existing medical checks to understand more about these issues. This could help find better ways to diagnose and treat these conditions early.
Austria · Germany · Israel - not yet recruitingNA
Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes
This study uses advanced MRI scans to find early signs of Parkinson's disease and a similar condition called PSP. The goal is to discover ways to diagnose these diseases earlier and help patients get better treatment.
France - active not recruitingPHASE2
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)
This study is looking into a new medication called FNP-223 for people with Progressive Supranuclear Palsy (PSP). It aims to see if FNP-223 can slow down the disease's progression and if it's safe to use. Half the participants will get FNP-223, and half will get a dummy medicine.
United States · France · Germany - active not recruitingPHASE1
A Study to Test the Safety and Tolerability of Long-term UCB0107 Administration in Study Participants With Progressive Supranuclear Palsy
This study is looking at the long-term safety of a new medicine, UCB0107, for people with Progressive Supranuclear Palsy (PSP). It builds on a previous study to understand if the treatment is safe over a longer period.
Belgium · Germany · Spain - recruitingNA
The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders
This study looks into how a new wearable device, CUE1, might help people with Parkinson's disease and similar conditions. It aims to improve common symptoms like movement difficulties and tiredness, and check if the device is safe and easy to use.
United Kingdom - recruiting
Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes
This study looks at how people with rare brain conditions like PSP, CBD, and MSA use healthcare services and how this affects their quality of life. It aims to understand which NHS services are most helpful.
United Kingdom