- not yet recruitingNA
A Case Series of Culturally-adapted CBTp for Black People in the UK
This study looks at a special type of talking therapy for Black people in the UK who experience psychosis. It checks if this therapy, which is adjusted for different cultures, is practical, comfortable, and safe for them.
United Kingdom - recruiting
Immune Mechanisms of Antipsychotic Treatment Response
This study looks at how your body's defence system, called the immune system, might affect psychosis and how well treatments work. They collect blood and spinal fluid to find better ways to diagnose and treat psychosis.
United Kingdom - not yet recruitingNA
Testing the Efficacy of the Cannabis Clinic for Patients With Psychosis (CCP) Intervention for Cannabis Use Reduction/Cessation in Patients With First Episode Psychosis (FEP)
This study looks at a special programme to help people with psychosis reduce or stop using cannabis. Cannabis can make psychosis worse, so this programme offers support through talking therapies and group sessions to improve care for these patients.
United Kingdom - recruitingNA
Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis Risk
This study explores if a medicine called levetiracetam can improve brain function and thinking in young adults at risk of psychosis. Researchers will use special brain scans to see how the medicine affects the brain.
United Kingdom - not yet recruitingNA
Developing a Virtual Reality-assisted Intervention for Emotion Regulation Difficulties in Psychosis
This study looks at using virtual reality (VR) to help people with psychosis manage their feelings better. It combines talking therapy with VR practice to assist people in handling emotions when they need to, making it easier to live their daily lives.
United Kingdom - not yet recruitingNA
The Mouth Matters in Mental Health Trial -2
This study looks at how a 'link worker' can help people with severe mental health issues attend dental appointments. It aims to see if this support improves their dental attendance and overall oral health, and if it's a good value for money for the NHS.
United Kingdom - recruiting
E-Detection Tool for Emerging Mental Disorders
This study is developing an online tool to help spot early signs of psychosis in young people aged 12-35. It uses questionnaires and short online activities to identify those who might be developing this condition, aiming for earlier support and better outcomes.
United Kingdom - not yet recruitingPHASE3
Stratification and Treatment in Early Psychosis Study -ASSIST
This study looks at whether adding a medicine called CBD to standard clozapine treatment helps people with tough-to-treat psychosis feel better. It also checks if CBD is safe. Participants will get either CBD or a dummy pill and continue their usual care.
Germany · Greece · Israel - not yet recruitingPHASE3
Stratification and Treatment in Early Psychosis Study - ENHANCE
This study looks at adding CBD oil to usual treatment for young people (16-40) experiencing their first episode of psychosis, who haven't fully improved yet. We want to see if CBD helps and is safe, compared to a dummy treatment.
Austria · Germany · Greece - recruitingPHASE3
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)
This study is looking at a new treatment called KarXT + KarX-EC for psychosis, which can affect people with Alzheimer's disease. Researchers want to see if this treatment is safe and helps reduce psychotic symptoms like hallucinations or delusions in individuals aged 55 to 90.
United States · Australia · Canada - recruitingNA
Early Psychosis: Investigating Cognition
This study explores brain chemistry changes in people who have recently experienced psychosis. It investigates how brain chemicals like glutamate might affect memory and attention, and if a mild electrical brain stimulation could offer a new, personalised treatment approach.
United Kingdom - active not recruitingPHASE2
IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2
This study looks at whether special treatments called immunotherapy can help people with a type of psychosis linked to the body's immune system. Researchers want to see if these treatments, intravenous immunoglobulin (IVIG) and rituximab, are safe and effective for this condition.
United Kingdom - recruiting
Psychodynamic Interpersonal Therapy for psychosis (PITp): a feasibility randomised controlled trial
This study looks into a talking therapy called PITp for people experiencing psychosis. It wants to see if this therapy, alongside usual NHS care, is a good idea for a larger study. Adults in Greater Manchester with psychosis can take part.
United Kingdom · England - active not recruiting
AMP SCZ® Observational Study: PREDICT-DPACC
This study aims to better understand and predict who might develop psychosis, a serious mental health condition. Researchers are looking for young people (12-30) who are at high risk but haven't had a full psychotic episode yet. The goal is to find ways to help people sooner.
United States · Australia · Canada