- recruitingTherapeutic exploratory (Phase II)
Evaluation of 64Cu-ATSM PET/CT as a predictor of response to neoadjuvant therapy in locally advanced rectal cancer (TEP-64Cu-ATSM-Rectum)
This study looks at a special scan called a PET/CT with a tracer called 64Cu-ATSM. It aims to see if this scan can predict how well treatments, given before surgery for advanced bowel cancer (rectal cancer), will work. The goal is to find better ways to plan care.
France - recruitingPHASE3
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
This study looks at a new drug, calderasib, for advanced bowel cancer with a specific genetic change (KRAS G12C). Researchers want to see if adding calderasib to standard treatments helps people live longer without their cancer growing.
United States · Argentina · Australia - not yet recruiting
Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology
This study looks at how doctors find and report 'tumour deposits' in bowel cancer. These small cancer spots affect how cancer behaves. We want to see if new guidelines mean they are now being consistently reported, which is crucial for patients to get the best treatment.
United Kingdom - recruiting
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
This study looks at a new blood test to find cancer early in people who have already been treated for certain cancers. It aims to see if this test can tell when cancer might come back, helping doctors give the best care sooner.
United States · France · Germany - recruiting
Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems
This study looks into a new way to monitor how well treatment is working for rectal cancer. It uses special MRI scans alongside radiotherapy to check early on if the cancer is responding to treatment, aiming to improve care for patients.
United States · France - not yet recruiting
Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal
This study is testing a new, smaller camera called a 'rectoscope' to check the lower bowel after polyps or small cancers have been removed. It aims to make these important checks easier and quicker, using a simple enema instead of strong bowel preparation, to help reduce waiting lists.
United Kingdom - recruitingNA
Dose Escalated Radiotherapy for Rectal Cancers Using MR-guided Radiotherapy
This study looks at giving a higher dose of radiotherapy for rectal cancer using a special MRI-guided machine. The aim is to increase the chance of getting rid of the cancer completely, potentially avoiding surgery and reducing long-term side effects.
United Kingdom