Refractory Chronic Cough research hub
5 indexed studies · 2 currently recruiting
- authorisedTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Study to Evaluate the Efficacy and Safety of Nalbuphine Extended-Release Tablets for the Treatment of Participants with Refractory Chronic Cough
This study tests a slow-release tablet called nalbuphine for people with long-lasting coughs that have not improved with usual treatments. Researchers want to see if different doses can safely reduce how often people cough over 24 hours, compared with a dummy pill, over a period of six weeks.
Poland - active not recruitingPHASE3
A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
This study is testing a new medicine, BLU-5937, for adults in the UK with a long-lasting cough that hasn't responded to other treatments. It aims to see if the medicine can reduce how often people cough over 24 weeks, compared to a dummy pill.
United States · Australia · Canada - recruitingNot Applicable
The effects of morphine treatment on functional brain scans in patients with chronic cough
This study looks at how a low dose of morphine affects the brains of people with long-term cough that hasn't responded to other treatments. We use special brain scans to see if morphine changes brain activity, hoping to understand this cough better and find new ways to treat it.
United Kingdom · England - not yet recruitingPHASE4
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
This study looks at new ways to help people with long-lasting coughs that haven't responded to usual treatments. It tests two medicines (low-dose morphine and pregabalin) and a special cough therapy, separately and together, to see which works best and is safest.
Canada - active not recruitingPHASE3
A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
This study is testing a new medicine called BLU-5937 for adults with a stubborn, long-lasting cough that hasn't responded to other treatments. It aims to see if the medicine can reduce how often people cough, compared to a dummy pill.
United States · Argentina · Belgium