- recruitingPHASE1
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
This study is testing a new drug, OKN4395, alone and with an existing cancer treatment, pembrolizumab, for various solid tumours. The main goals are to check its safety, how well it's tolerated, and if it helps fight cancer.
United States · Australia · United Kingdom - not yet recruitingPHASE2
Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing
This study compares two types of wound dressings after sarcoma surgery: standard ones and special 'negative pressure' dressings. We want to see if the special dressings reduce wound problems and how they affect recovery and NHS costs. It's for people aged 16+ having sarcoma surgery.
United Kingdom - recruitingPHASE1, PHASE2
HTL0039732 in Participants With Advanced Solid Tumours
This study is testing a new drug, HTL0039732, alone and with another cancer medicine, atezolizumab. It's for people with advanced solid tumours, aiming to see if blocking certain signals can help the immune system fight cancer. The goal is to find the right dose and see how well it works.
United Kingdom - recruitingNA
Salutare One Referral Software Impact on Multi-Disciplinary Team (MDT) Meetings Effectiveness and Safety
This study is testing new software called 'Salutare One Referral'. It helps hospital teams better plan care for cancer patients by making their meetings quicker and more effective. The aim is to improve how decisions are made and get patients better care, faster.
United Kingdom - recruiting
Ex VIvo DEtermiNed Cancer Therapy
This study, called EVIDENT, wants to see if we can test a tiny piece of your tumour in the lab to predict how well cancer treatments will work for you. It's for people with various solid cancers, like bladder or kidney cancer, who are having surgery or a biopsy.
United Kingdom - authorisedPhase I and Phase II (Integrated)- Other
Phase 1b/2 Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Previously Treated Unresectable Advanced or Metastatic Sarcomas
This study is looking at a new drug, Risvutatug Rezetecan, for people with advanced sarcoma that can't be removed by surgery or has spread. It aims to see how well the drug works and if it's safe for patients who have already had other treatments.
France - recruiting
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
This study looks at how new ways to treat high-risk sarcoma, a type of cancer, can be made more personal. Researchers are collecting information and samples from patients to find the best treatments before surgery, aiming for better results.
United Kingdom - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - authorisedPhase II and Phase III (Integrated)
The SURF trial: Optimizing Surgical excision Using Real-time Fluorescence imaging with indocyanine green
The SURF trial is testing a new way to help surgeons find and remove all cancer during an operation. It uses a special dye that glows, helping doctors see cancer cells more clearly. This aims to improve surgery outcomes for various cancer types.
Netherlands