- recruitingPHASE1
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
This study is for adults with advanced cancers in places like the lungs or stomach that are hard to treat or have spread. It's testing a new drug, PF-08046050, to see if it's safe and helps shrink these cancers, sometimes with other medicines.
United States · Canada · China - active not recruitingPHASE3
Pembrolizumab/Vibostolimab (MK-7684A) or Atezolizumab in Combination With Chemotherapy in First Line Treatment of Extensive-Stage Small Cell Lung Cancer (MK-7684A-008/KEYVIBE-008)
This study looked at new ways to treat a type of lung cancer called extensive-stage small cell lung cancer (ES-SCLC). It compared a combination of medicines with standard chemotherapy to see if it could help people live longer. The study was changed partway through, so the focus shifted.
United States · Argentina · Australia - recruitingPHASE2
DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers
This study is for adults with certain advanced cancers, including small cell lung cancer. It tests a new treatment called BI 764532 to see if different doses are safe and can shrink tumours. Sometimes, this treatment is called obrixtamig.
United States · Belgium · Bulgaria - recruitingPHASE1
A Study of LY4175408 in Participants With Advanced Cancer
This study is looking at a new medicine called LY4175408 for people with certain advanced cancers, including lung, womb, and a type of breast cancer. It aims to see if the medicine is safe, how well it works, and how the body handles it.
United States · China · France - active not recruiting
A French Real-life Study: EvaluatioN of durvALumab Utilization and Effectiveness for First Line Extensive Stage Small Cell Lung Cancer.
This study looks at how a new drug, durvalumab, works for people with a serious type of lung cancer called extensive stage small cell lung cancer. It checks its real-world benefits and safety outside of strict trial conditions in France.
France - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - active not recruitingPHASE1
Study Evaluating Safety, Tolerability and Pharmacokinetics (PK) of Tarlatamab in Adults With Small Cell Lung Cancer (SCLC)
This study is testing a new medicine called tarlatamab for adults with small cell lung cancer. It aims to see how safe it is, how well people tolerate it, and how it moves through the body.
United States · Australia · Austria