- active not recruitingPHASE2
Efficacy and Safety of L19TNF in Previously Treated Patients with Advanced Stage or Metastatic Soft-tissue Sarcoma
This study is testing a new combination treatment for advanced soft tissue sarcoma. It combines a drug called onfekafusp alfa with dacarbazine. Researchers want to see if this combination is safe and effective for people who have already had other treatments.
France · Germany · Italy - active not recruitingNA
RNASARC - Molecular Screening Program of Soft Tissue Sarcomas With Complex Genomic Profile to Detect NTRK1/2/3, ROS1 or ALK Gene Fusions.
This study looks for specific gene changes (NTRK, ROS1, ALK fusions) in soft tissue sarcomas. We check tumour samples for these changes using special tests. Finding these changes helps us guide patients to suitable treatments, potentially including a drug called entrectinib.
France - active not recruitingPHASE1
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
This study is testing a new drug, AVA6000, for people with advanced solid tumours like breast, ovarian, or salivary gland cancer. It aims to find a safe dose and see how well it works when standard treatments may no longer be effective.
United States · United Kingdom - recruitingPHASE3
Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)
This study is looking at a new medicine called AL3818 (anlotinib) for people with advanced alveolar soft part sarcoma (ASPS). It aims to see how safe and effective it is. Currently, it's only for ASPS patients.
United States · China · Italy - recruitingNA
Neoadjuvant Irradiation of Extremity Soft Tissue Sarcoma With Ions
This study is testing a new, shorter radiation treatment for a type of cancer called soft tissue sarcoma in the arms or legs. It uses special types of radiation (protons or carbon ions) to see if it's safe and works well, hoping to reduce side effects and improve recovery.
Germany - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
This study is testing a cancer drug called capmatinib to see if it can help adults with different types of cancer that share a specific genetic change (MET mutation). It's already approved for some lung cancers, and now researchers want to know if it works for other cancers too.
United Kingdom - recruitingNA
Study Comparing Negative Pressure Dressing vs Conventional in Patients With Resected STS After Radiotherapy
This study looks at how well a special 'negative pressure' dressing works compared to a normal dressing for wound healing after surgery for a type of cancer called Soft Tissue Sarcoma. Participants have already had radiotherapy before their surgery.
France - recruitingPHASE2
A Study to Evaluate Pre-operative HYPOfractionated Radiation Therapy in Aged (≥ 70 Years Old) or "Fragile" (≥ 65 Years) Patients With Limb or Trunk Soft Tissue SARComa.
This study looks at a special type of radiation therapy given before surgery for soft tissue sarcoma. It focuses on older patients (70+) or those aged 65-69 who are considered 'fragile'. The aim is to see how this treatment affects wound healing and recovery.
France - active not recruitingNA
Surveillance AFter Extremity Tumor surgerY
This study looks at the best ways to check for cancer returning in patients who've had surgery for a soft tissue sarcoma in an arm or leg. It compares how often we check and what scans we use.
United States · Argentina · Australia - recruitingPHASE3
Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)
This study is looking for people with a type of cancer called leiomyosarcoma (LMS) that has already been treated. It's testing a new medicine (ADI-PEG 20) against a dummy medicine (placebo) alongside standard treatments to see if it's safe and helps improve outcomes.
United States · Canada · Taiwan - recruitingPHASE1
In Vivo Lung Perfusion for Pulmonary Metastases of Sarcoma
This study explores a new way to treat sarcoma that has spread to the lungs. It involves delivering chemotherapy directly into one lung during surgery to kill cancer cells, aiming to reduce side effects and improve outcomes compared to standard treatments.
Canada - recruitingNA
HIFU Ablation of Soft Tissue Sarcoma
This study in Oxford is exploring a new, non-invasive treatment called HIFU for soft tissue sarcoma and desmoid tumours. It uses focused ultrasound to destroy cancer cells and aims to understand its safety and effectiveness, offering a different option for patients.
United Kingdom - active not recruitingPHASE1, PHASE2
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
This study is testing a new injection, IP-001, after a heat treatment called thermal ablation for certain advanced cancers (bowel, lung, soft tissue sarcoma) that haven't responded to previous treatments. It aims to see if it's safe and effective, potentially offering a new treatment option.
United States · France · Germany - active not recruitingPHASE1, PHASE2
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
This study looks at a new medicine called Selpercatinib for children and young people (ages 6 months to 21 years) with certain advanced solid tumours or brain tumours. It's for those whose tumours have a specific genetic change (called RET alteration).
United States · Australia · Canada