- recruitingPHASE1, PHASE2
Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors
This study is testing a new medicine, TH9619, for people with advanced cancers like bowel, head and neck, lung, and stomach cancer. It's the first time TH9619 is being given to people, and doctors want to find the safest and most effective dose.
France · Spain · United Kingdom - active not recruitingPHASE3
A Trial Evaluating the Addition of Nivolumab to Cisplatin-RT for Treatment of Cancers of the Head and Neck
This study looks at adding a new drug, nivolumab, to standard treatment for head and neck cancer after surgery. Researchers want to see if this combination improves health and prevents the cancer from coming back, without causing more problems.
France - recruitingPHASE3
Study on the Efficacy of Treatment by Radiotherapy and Pembrolizumab in Newly Diagnosed Metastatic Head & Neck Cancers
This study looks at new ways to treat advanced head and neck cancer. It combines radiotherapy and a drug called pembrolizumab, sometimes with chemotherapy, to see if it works better than standard treatments for newly diagnosed patients.
France - recruitingPHASE1
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
This study is testing a new drug called sigvotatug vedotin for people with several types of advanced cancer. Researchers want to see if it's safe, what side effects it causes, and if it can help treat cancer, sometimes in combination with other common cancer medicines.
United States · France · South Korea - recruitingPHASE2
European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]
This study looks at treating advanced throat cancer (larynx or hypopharynx) with chemotherapy and radiation, adding a new drug, Pembrolizumab (Keytruda®). It aims to see if this new treatment can help patients keep their larynx and live longer, healthier lives.
Germany - recruitingPHASE1, PHASE2
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
This study is testing a new drug, UCB4594, for advanced cancers. It's the first time it’s being used in people. Researchers want to find the safest dose, understand side effects, and see if it can shrink certain tumours by helping the body's immune system.
United Kingdom - active not recruitingPHASE1
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
This study looks at a new drug, KFA115, on its own and with another drug, pembrolizumab, for various advanced cancers. It aims to find a safe and effective dose, helping doctors understand how these treatments work.
United States · Canada · China - recruitingPHASE1, PHASE2
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
This study is testing a new drug, BMS-986340, by itself and with other treatments for different advanced cancers. Researchers want to find the safest dose and see how well it works. This is the first time BMS-986340 has been tried in people.
United States · Australia · Canada - recruitingNA
App-based Recording and Optimization of the Nutritional Status in Patients With Head and Neck Tumors During and After Radio(Chemo)Therapy
This study looks at how an app can help people with head and neck cancer manage their nutrition during and after treatment. It aims to reduce weight loss and poor nutrition by using app reminders and checking in on how people are eating.
Germany - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - recruitingPHASE3
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
This study is looking at a new treatment for head and neck cancer that has come back or spread. It combines a new drug, amivantamab, with standard treatments to see if it works better than standard care alone to fight the cancer.
United States · Australia · Austria - active not recruitingPHASE1, PHASE2
A Clinical Trial Evaluating TG4050 in Head and Neck Cancer
This study is testing a new treatment called TG4050 for a type of head and neck cancer. It's looking at how safe and effective the treatment is in patients who have already had their main cancer treated.
United States · France · Spain - recruitingPHASE1, PHASE2
A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer
This study looks at new ways to treat head and neck cancer using a drug called Amivantamab, sometimes combined with other treatments. It aims to find out if these treatments are safe and how well they work for people with different types of head and neck cancer.
United States · China · France - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to investigate the safety and tolerability of intravenous QEQ278 in patients with advanced solid tumors
This study is looking into a new medicine called QEQ278 for people with advanced cancers like lung, oesophageal, kidney, or head and neck cancer. It's the very first time this medicine is being given to people, and the main aim is to see if it's safe to use and how well people tolerate it.
France · Italy · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Study of REGN6569 and Cemiplimab in Adult Patients with Advanced Solid Tumor Malignancies
This early-stage study is testing a new combination of medicines, REGN6569 and Cemiplimab, to see if they are safe and work for adults with advanced head and neck squamous cell carcinoma. It's looking for people willing to try a new treatment approach.
Spain - ongoing, recruitingTherapeutic exploratory (Phase II)
EORTC 2120-HNCG: Radiotherapy plus xevinapant or placebo in older patients with locally advanced head and neck squamous cell carcinoma: a randomized phase II study (Ravina)
This study looks at a new drug, xevinapant, given with radiotherapy for older patients with advanced head and neck cancer. We want to see if this combination helps more people live longer without their cancer coming back. It's a Phase II study, meaning we're testing its effectiveness and safety.
Italy · Slovenia · Germany