To restore coagulation in patients taking DOACs who are experiencing research hub
34 indexed studies · 29 currently recruiting
- recruitingHuman Pharmacology (Phase I)- Other
A study to investigate VMX-C001 in healthy volunteers.
This study is testing a new medicine, VMX-C001, in healthy people. The medicine aims to help people who are bleeding because they take blood thinners, or who need their blood thinned reversed for urgent surgery. It's an early-stage study to see how the medicine works safely.
Netherlands - recruiting
EMUs: Enhanced Monitoring Using Sensors After Surgery
This study looks at using small, wearable sensors to spot if patients are becoming unwell after surgery. It aims to see if these sensors can help nurses and doctors notice problems sooner, making recovery safer for patients.
Benin · Ghana · Guatemala - recruiting
Pilot study of a smart in tracheal tube designed to monitor breathing and body functions (iTraXS 1)
This study tests a new breathing tube called iTraXS during surgery. It has tiny sensors to check breathing and tube position, aiming to make surgery safer. It's the first test in patients, looking at how well it works and if it's easy for staff to use.
United Kingdom · England - recruiting
Informing the design of a clinical trial into umbilical hernia repair
This study helps us design a future trial about fixing a belly button hernia that's causing problems. We'll ask patients about their symptoms and quality of life before and after surgery to learn how best to choose participants and make sure surgeons are happy to try different ways of fixing a hernia.
United Kingdom · England - active not recruitingNA
Blood Salvage in Orthotopic Liver Transplantation With HCC
This study looks into using a patient's own blood during liver transplant surgery for a type of liver cancer (HCC). We want to see if it's safe and helpful to give their blood back to them, or if it's better to use donated blood.
Canada - recruitingPHASE4
TES RCT Fleet Enema vs Oral Mechanical Bowel Prep
This study compares two ways to clean the bowel before a special type of surgery called Transanal Endoscopic Surgery (TES). Researchers want to see if a liquid given into the bottom (enema) works better or worse than a drink (oral preparation) for cleaning the bowel, making surgery safer.
Canada - enrolling by invitationNA
Induce XT™ Bone Graft in Foot and Ankle Fusion
This study looks at a new material called Induce XT for foot and ankle surgery. It's used to help bones heal and fuse together. We want to see how well it works and if it's a good option for patients.
Canada - recruitingNA
Enhanced Vitals Monitoring After Major Surgery Trial
This study looks at using special monitoring devices for vital signs after major surgery, both in hospital and at home. It aims to see if closer monitoring helps patients recover better and spend more days at home alive within 30 days after their operation.
Canada - recruitingNA
Postoperative Electrical Muscle Stimulation Two
This study looks at whether electrical muscle stimulation and protein drinks can help people keep their muscle strength after major tummy surgery for cancer. Losing muscle can make it harder to get back to normal activities, so researchers want to find ways to prevent it.
United Kingdom - not yet recruitingNA
Evaluation of A-DIVA Score Effectiveness at Admission for Preserving Venous Capital in Patients With Difficult Access
This study looks at a tool called A-DIVA to help nurses find the best veins for drips. It aims to reduce repeated needle pokes and pain when people are in hospital, especially those with hard-to-find veins.
France - recruiting
To Evaluate the Performance and Efficiency of Robotic Surgery in Children and Adults
This study looks at how well robotic surgery works for both children and adults. It wants to see if robots make surgery safer and more efficient, especially for kids, and how much it costs compared to traditional surgery. They gather information on the benefits and challenges of using robots in operations.
France - recruiting
Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application
This study looks at how UK doctors set breathing machines for patients having chest surgery where only one lung works. It compares current settings with those suggested by a smartphone app to see if they prevent a common breathing problem called acidosis, ensuring patients breathe comfortably and safely.
Canada - recruitingNA
Norepinephrine Weaning Guided by the Hypotension Prediction Index in Vasoplegic Shock After Cardiac Surgery
This study looks at how to safely reduce a common medicine called norepinephrine after heart surgery. It tests if using a special device that predicts low blood pressure can help patients stop taking this medicine sooner, which might be better for their recovery.
France - not yet recruitingNA
Vitaliti Continuous Vital Signs Monitor User-Testing Protocol: VERDICT-2
This study is testing a new wearable device called Vitaliti for people recovering from surgery at home. It checks your vital signs constantly. We want to see how easy it is to use for patients, their families, and doctors, and if it helps with recovery.
Canada - recruitingNA
Influence of FreeO2 on Percentage of Time Within Oxygen Saturation Target Using Noninvasive Ventilation (NIV) and Continuous Positive Airway Pressure (CPAP) for Patients Admitted for AECOPD or Bariatric Surgery
This study looks at a new device called FreeO2 to help people breathe better. It's for patients with lung conditions or those recovering from weight-loss surgery. The aim is to keep oxygen levels just right and avoid problems that can happen when oxygen levels are too high or too low.
Canada - active not recruitingNA
Implementation and Assessment of the BE-FIT Program
This study looks at a new exercise plan for older adults in hospital after surgery. It aims to help them move more, recover faster, and avoid problems like falls, leading to shorter hospital stays.
Canada - recruitingNA
Prehab for Lung and Esophageal Cancer
This study looks at a special 8-week health coaching programme for people having surgery for lung or gullet (oesophageal) cancer. It helps them get ready for surgery by improving their fitness, nutrition, and well-being, hoping for better recovery and quality of life.
Canada - recruitingPHASE4
Pre- Vs. Postoperative Thromboprophylaxis in Pancreatic Surgery
This study compares when to give blood clot prevention medicine for pancreatic surgery: either before or after the operation. It aims to find the safest and most effective timing to reduce risks like blood clots and bleeding. This is important because current guidelines differ.
Canada · Finland · Norway - recruitingNA
Virtual Reality in Awake Surgery : Pilot Study VIRAS
This study looks at using virtual reality (VR) headsets during operations where patients are awake. The aim is to see if VR can help reduce worry and discomfort for people having brain surgery while conscious, and to check that the VR equipment is safe and tolerated well.
France - active not recruiting
FIT Study (Functional Outcomes In Trauma Study)
This study looks at how people recover after serious injuries, like those from a car accident. We want to understand their journey over time, how they cope physically and emotionally, and what helps them get back to their normal lives. This will help improve care for future patients.
United Kingdom - not yet recruitingPHASE3
Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia
This study looks at using a common painkiller called lidocaine, given through a drip, alongside standard spinal pain relief (morphine) during major tummy surgery. We want to see if lidocaine helps reduce the amount of morphine needed for pain relief in the two days after surgery.
France - active not recruitingNA
Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology-3 Trial
This study looks at whether a virtual care program with smart monitoring devices helps adults recovering at home after non-heart surgery. It compares this new approach to standard hospital care to see if it reduces hospital stays and emergency visits.
Canada - recruiting
Maestro 1.1 Post-Market Registry
This study looks at how a new surgical tool, called the Maestro Platform, is used during keyhole surgery in adults. It helps doctors understand how this technology works in real-life operations.
United States · Belgium · France - recruitingPHASE3
Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
This study looks at two medicines, tranexamic acid and desmopressin, to see if they can reduce serious bleeding in people with kidney disease who are having surgery. It's a first step to see if a bigger study should be done.
Canada - recruitingNA
Postoperative Analgesia Intervention With Non-opioid Alternatives (PAIN-Alt) Trial - Breast Surgery
This study looks at treating pain after breast surgery without strong opioid painkillers. We’re comparing pain relief using only non-opioid medicines to pain relief that includes opioids. The aim is to find effective ways to manage pain and reduce reliance on strong painkillers, which can have serious side effects like addiction.
Canada - recruitingNA
Improving Patient Sleep Prior to Elective Surgery
This study looks at how improving sleep before surgery can help patients recover better. We're offering special sleep support to some patients to see if it makes a difference to their sleep and recovery compared to standard care.
Canada - active not recruiting
Children's Acute Surgical Abdomen Programme
This study looks at the emergency stomach surgeries children have in the UK. We want to understand current care, find ways to improve it, and help doctors make the best decisions for children aged 1 to 16.
United Kingdom - recruiting
Terumo Aortic Global Endovascular Registry
This study looks at how well Terumo Aortic grafts work for people with aortic aneurysms. It collects real-world information on different types of grafts after they've been approved for use, helping us understand their safety and how patients recover.
United States · Belgium · France - recruitingNA
An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse
This study looks at how giving extra arginine, a nutrient, might help babies born early or those needing major bowel surgery. It aims to understand if arginine can improve their immune system and recovery after surgery, by studying their blood and nutrition.
United Kingdom - recruiting
CMR Right Ventricular Contractile Reserve Following Lung Resection
This study looks at how lung surgery affects heart health. We're using special heart scans to see if removing part of a lung changes how the heart's right side works, and if this affects how well people can do daily activities.
United Kingdom - recruitingNA
Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections
This study looks at a new light-based treatment for preventing infections after nasal surgery. It compares whether using this treatment on your nose before surgery can reduce the need for antibiotics afterwards, compared to a cleaning solution alone.
United Kingdom - recruitingNA
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
This study compares two ways of doing keyhole knee surgery (unicondylar knee arthroplasty) for knee arthritis: robot-assisted (Mako) versus the traditional method (Oxford). It looks at how well the new knee joint is put in and how patients get on afterwards to see if one method is better.
United Kingdom - recruiting
A Platform Study for solId orgaN CancERs
This study aims to collect tiny samples of tissue and blood from cancer patients undergoing surgery or biopsy. These samples will help researchers understand solid organ cancers better and develop new ways to diagnose and treat them. It's designed to make it easier for researchers to get high-quality samples.
United Kingdom - recruitingNA
GRACE: Evaluating Compression Stockings in Patients That Require Extended Duration Pharmacological Thromboprophylaxis
This study looks at whether wearing special stockings helps prevent blood clots after major surgery, even when patients are already taking blood-thinning medicine. It aims to see if the stockings add extra benefit or if they can be safely avoided, considering their costs and potential downsides.
United Kingdom