- ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Doses of RO7303509 in Patients with Systemic Sclerosis
This study is looking at a new medicine called RO7303509 for people with Systemic Sclerosis. It wants to see if the medicine is safe, how the body handles different doses, and if there are any side effects. This is one of the first studies in humans.
Germany · Belgium · France - enrolling by invitation
Chest CT Biomarkers as Prognostic Predictors in SSc-ILD
This study looks at CT scans of lungs in people with Systemic Sclerosis (SSc). It aims to find early signs in the scans that can predict if their lung condition (ILD) will get worse, so doctors can help them sooner.
France · Germany · Italy - active not recruitingPHASE3
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)
This study, DAISY, is testing a new treatment called Anifrolumab for adults with Systemic Sclerosis (also known as Scleroderma). We want to see if it's safe and effective compared to a dummy treatment, to help improve symptoms and quality of life.
United States · Austria · Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, randomised, placebo-controlled, double-blind, parallel-group, efficacy and safety study of at least 48 weeks of oral BI 685509 treatment in adults with progressive systemic sclerosis
This study is testing a new tablet called BI 685509 for adults with a condition called systemic sclerosis. It aims to see if the tablet can slow down lung damage and improve other symptoms, compared to a dummy pill.
Spain · Denmark · France - recruitingPHASE1
A Study of AZD0120 in Autoimmune Diseases
This study is looking at a new treatment called AZD0120 for certain long-term conditions like systemic sclerosis, inflammatory muscle diseases, and severe rheumatoid arthritis. It's an early-stage study to see how safe the treatment is and if people can tolerate it.
United States · Australia · Germany - recruitingPHASE3
A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis
This study looks at a new treatment called BMS-986353 for severe Systemic Sclerosis. It compares this new treatment with standard care to see if it's more effective and safe for people with this condition.
United States · Belgium · Canada - authorisedTherapeutic use (Phase IV)
Investigating the (autoreactive) B cell compartment in antibody-mediated autoimmune diseases in comparison with the recall Tetanus Toxoid response
This study looks at how the body's immune cells, called B cells, behave in diseases like lupus and rheumatoid arthritis. It compares them to B cells that react to a tetanus shot to understand more about these conditions.
Netherlands