Chronic Inflammatory Disease research hub
16 indexed studies · 13 currently recruiting
- recruitingNA
Deployment o the Multidisciplinary Prospective Cohort Imminent
This study aims to better understand long-term inflammatory diseases like lupus and severe asthma. Researchers will collect information and samples to find new ways to treat these conditions, reduce side effects, and improve daily life for patients. It's about finding better treatments for the future.
France - enrolling by invitation
Chest CT Biomarkers as Prognostic Predictors in SSc-ILD
This study looks at CT scans of lungs in people with Systemic Sclerosis (SSc). It aims to find early signs in the scans that can predict if their lung condition (ILD) will get worse, so doctors can help them sooner.
France · Germany · Italy - active not recruitingPHASE3
Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)
This study, DAISY, is testing a new treatment called Anifrolumab for adults with Systemic Sclerosis (also known as Scleroderma). We want to see if it's safe and effective compared to a dummy treatment, to help improve symptoms and quality of life.
United States · Austria · Belgium - recruitingNA
Efficacy of a Personalized Rehabilitation Program of Facial Involvement in Systemic Sclerosis
This study looks at a special exercise program for people with systemic sclerosis who have face problems. It aims to see if this personalized program works better than usual care to help with face stiffness, mouth difficulties, and how people feel about their face.
France - not yet recruitingPHASE3
A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis
This study is testing a new medicine, nerandomilast, for people with systemic sclerosis. It aims to see if the medicine can improve symptoms and slow the disease. Adults with systemic sclerosis might be able to join this study.
United States · Argentina · Australia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Doses of RO7303509 in Patients with Systemic Sclerosis
This study is looking at a new medicine called RO7303509 for people with Systemic Sclerosis. It wants to see if the medicine is safe, how the body handles different doses, and if there are any side effects. This is one of the first studies in humans.
Germany · Belgium · France - recruitingPHASE2
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study
This study looks into a new way to treat hard lumps under the skin caused by certain illnesses like Systemic Sclerosis and Dermatomyositis. Researchers are testing a medicine called Sodium Thiosulfate (STS), given as an injection, to see if it can help reduce these lumps and improve patients' lives.
France - recruitingPHASE2, PHASE3
Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk
This study is looking into whether a common blood-thinning medication called clopidogrel can help prevent a serious disease called systemic sclerosis (scleroderma) from developing in people who show early signs. It's an important step toward finding ways to stop this condition before it fully takes hold.
France - recruitingNA
Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre
This study looks at how scleroderma (a rare condition affecting skin and organs) changes over 5 years. Researchers collect blood and tissue samples to better understand this disease, as there is currently no cure. They hope to improve future treatments.
France - recruitingPHASE1
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
This study looks at a new treatment called ALLO-329 for serious autoimmune diseases like lupus and scleroderma. It's the first time this treatment is being used in people. Doctors want to see if it's safe, how well people tolerate it, and if it shows early signs of helping patients get better.
United States · Canada - recruitingPHASE2
Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease
This study looks into using mycophenolate mofetil for systemic sclerosis patients with early lung problems. It aims to see if an earlier treatment can help prevent the lung condition from getting worse and test if a larger study is possible.
Canada - recruitingPHASE1
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
This study is testing a new cell therapy called CC-97540 for severe autoimmune diseases like lupus and rheumatoid arthritis. It aims to see if it's safe, how well it works, and how the body handles it, especially when other treatments haven't helped.
United States · Belgium · France - recruiting
Evaluation of HRCT Patterns in Systemic Sclerosis-associated Interstitial Lung Disease
This study looks at lung scans (HRCT) of people with a condition called Systemic Sclerosis (SSc). Many people with SSc also get lung problems (Interstitial Lung Disease or ILD). Researchers want to see if patterns on these scans can help understand how severe or quickly their ILD might progress.
France - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase II, randomised, placebo-controlled, double-blind, parallel-group, efficacy and safety study of at least 48 weeks of oral BI 685509 treatment in adults with progressive systemic sclerosis
This study is testing a new tablet called BI 685509 for adults with a condition called systemic sclerosis. It aims to see if the tablet can slow down lung damage and improve other symptoms, compared to a dummy pill.
Spain · Denmark · France - recruitingPHASE3
A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis
This study looks at a new treatment called BMS-986353 for severe Systemic Sclerosis. It compares this new treatment with standard care to see if it's more effective and safe for people with this condition.
United States · Belgium · Canada - recruitingPHASE1
A Study of AZD0120 in Autoimmune Diseases
This study is looking at a new treatment called AZD0120 for certain long-term conditions like systemic sclerosis, inflammatory muscle diseases, and severe rheumatoid arthritis. It's an early-stage study to see how safe the treatment is and if people can tolerate it.
United States · Australia · Germany