Non-small Cell Lung Cancer research hub
9 indexed studies · 6 currently recruiting
- recruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
United States · Denmark · Hong Kong - recruitingPHASE1
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
This study is testing a new medicine, PF-07799933, for advanced cancers with a specific gene change (BRAF alterations). It aims to see how safe and effective it is, sometimes combined with other medicines, for people when usual treatments haven't worked.
United States · Canada · Israel - active not recruitingPHASE3
ESTIMation of the ABiLity of Prophylactic Central Compartment Neck Dissection to Modify Outcomes in Low-risk Differentiated Thyroid Cancer
This study looks at treating low-risk thyroid cancer. It compares removing only the thyroid gland to removing the thyroid gland plus nearby lymph nodes, to see if both approaches are equally good at preventing the cancer from coming back.
France · Guadeloupe · Reunion - recruiting
To Perform a Post-market Study of the Performance of the Idylla ThyroidPrint Assay Using Clinical Samples in Predicting the Nature of Indeterminate Thyroid Nodules (ITNs) Across Multiple Centers.
This study looks at a new lab test, Idylla ThyroidPrint, for thyroid lumps that doctors aren't sure about. It checks how well the test can tell if a lump is harmless or cancer, comparing it to what's found after surgery.
United Kingdom - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - active not recruitingPHASE2, PHASE3
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
This study, called IoN, is looking at whether radioactive iodine treatment is always needed for people with a common type of low-risk thyroid cancer. It compares giving the treatment with not giving it, to see if patients do just as well without it.
United Kingdom - recruitingNA
The Safety and Feasibility of Radiofrequency Ablation to Treat Low-risk Thyroid Cancer
This study is looking at a new treatment called radiofrequency ablation (RFA) for small, low-risk thyroid cancers (2cm or less). It wants to see if RFA is safe and practical, aiming to help people recover well and avoid traditional surgery.
Canada - active not recruiting
Differentiation of Benign From Malignant Thyroid Nodules Using Diffuse Reflectance Spectroscopy
This study is looking at a new way to tell if thyroid lumps are harmless or cancerous. Doctors currently use scans and biopsies, but sometimes it's still unclear. This research uses a special light probe on tissue removed during surgery to see if it can help get a clearer answer, especially in these uncertain cases.
United Kingdom - recruiting
Investigating Utility of ctDNA and Tumour Evolution in Advanced Thyroid Cancer
This study aims to understand how advanced thyroid cancer behaves, even after treatment. Researchers will collect blood and tissue samples to look for tiny bits of cancer DNA (ctDNA). This could help us track the disease better and create more personalised treatments in the future.
United Kingdom