Treatment Resistant Depression research hub
8 indexed studies · 5 currently recruiting
- recruitingPHASE2
An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression
This study is looking at a new nasal spray called BPL-003 for people with depression that hasn't responded to other treatments. It will check if it's safe, how well it's tolerated, and how it affects the body, either alone or with common antidepressants.
United Kingdom - recruitingPHASE3
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
This study looks into new ways to treat severe depression when first treatments haven't worked well. It compares an intensive use of esketamine (a type of ketamine) with usual care, aiming to find better and faster relief for people struggling with depression.
Austria · Germany · Greece - recruiting
A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.
This study looks at how well and how safely Vagus Nerve Stimulation (VNS) therapy works for people in the UK with severe depression that hasn’t improved with other treatments. It tracks their progress over several years after receiving the treatment.
Austria · Belgium · Germany - active not recruitingPHASE3
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
This study is looking at a new treatment called COMP360 (which contains psilocybin) for people with depression that hasn't improved with other treatments. Researchers want to see if it helps reduce depression symptoms and is safe, with participants receiving two doses alongside support.
United States · Canada · Czechia - recruitingPHASE2
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
This study is testing a new film treatment (VLS-01) for depression that hasn't responded to other treatments. It will check if the film helps improve mood, how safe it is, and if people can tolerate it, compared to a dummy treatment.
United States · Australia · Canada - authorisedTherapeutic exploratory (Phase II)
Psilocybin in treatment-resistant depression
This study is looking into whether a substance called psilocybin could help people with depression that hasn't responded to other treatments. Researchers want to see if it lessens depression symptoms one week after four weeks of treatment.
Austria - authorisedTherapeutic exploratory (Phase II)
Efficacy of psilocybin and trazodone combination in treatment-resistant depression: a randomized controlled proof-of-concept study (PSILOTRAZ)
This study is looking into whether a combination of psilocybin and trazodone can help people with depression that hasn't responded to other treatments. Researchers want to see if this new approach can improve mood and reduce depression symptoms.
France - not yet recruiting
Mental Health Mission Mood Disorder Cohort Study
This study aims to understand why some people with depression respond to treatment better than others. It looks at various factors like symptoms, genes, and body chemistry to find new ways to improve diagnosis and treatment for mood disorders.
United Kingdom