- recruitingHuman Pharmacology (Phase I)- First administration to humans
A phase I study investigating the local tolerability and pharmacokinetics of isoniazid (INH) inhalation by wet nebulization in patients with tuberculosis
This early-stage study tests a new way to take isoniazid, a common tuberculosis (TB) medicine. Instead of swallowing a tablet, participants breathe in the medicine as a fine mist through a nebuliser. Researchers want to see if this method is safe, comfortable, and well tolerated by the lungs.
Netherlands - recruitingHuman Pharmacology (Phase I)- Other
A Single Ascending Dose, Single-Centre Study, to Assess Pharmacokinetics, Safety and Tolerability of a Single Intramuscular Dose of Bedaquiline Long-Acting Injection Formulation in Healthy Participants
This study is testing a new, long-lasting form of a tuberculosis medicine called bedaquiline. It aims to see how safe it is, how the body handles it, and if it could help fight tuberculosis more effectively with fewer injections.
Austria - recruitingHuman Pharmacology (Phase I)- Other
A Trial to Determine if Quabodepistat is Processed Differently in Adults with Reduced Liver Function Compared to Adults with Normal Liver Function
This study looks at how a new medicine, quabodepistat, used for tuberculosis (TB), is handled by the body. Researchers want to see if it works differently in adults who have problems with their liver compared to those with healthy livers. This will help make sure the medicine is safe and effective for everyone.
Bulgaria - completed
Characteristics of the early immune response in airway and blood in people with latent tuberculosis (TB) infection and active TB disease.
Tuberculosis (TB) can stay hidden in the body without making you feel sick. This study looks at blood and lung samples from people with active or sleeping TB. Researchers hope to learn how our immune systems react, so doctors can spot who might become unwell and offer earlier treatment.
United Kingdom - recruitingHuman Pharmacology (Phase I)- Other
A study to investigate the pharmacokinetics of a combined oral contraceptive when given alone and in combination with GSK3036656 in female participants of non-childbearing potential aged 18 to 65 years of age
This study is looking at how a combined contraceptive pill works in the body when taken with an experimental tuberculosis medicine called GSK3036656. It's for women aged 18 and older who can't have children anymore.
Spain - recruitingHuman Pharmacology (Phase I)- First administration to humans
Safety and immune responses after vaccination with two investigational RNA-based vaccines against tuberculosis in healthy volunteers
Scientists are testing new vaccines to protect against tuberculosis. They want to see if two new experimental jabs are safe for healthy people and if they help the body's immune system fight off the disease. This is one of the very first studies in humans.
Germany - not yet recruiting
TB Stigma in the UK: Patients Experiences and Everyday Responses
This study looks at how people in the UK feel about having tuberculosis (TB). It explores their experiences with stigma, which is when people feel negatively judged or treated differently because of their illness. The aim is to understand common challenges and improve support for patients.
United Kingdom - recruiting
Lung Innate Immunity and Microbiome After Tuberculosis Exposure
This study looks at how your body's early defences (immune system) and the tiny germs living in your lungs (microbiome) react after you've been near someone with TB. We want to understand what helps some people avoid getting sick, hoping to find better ways to prevent TB.
United Kingdom - active not recruitingNA
ID93/GLA-SE Vaccination + BCG Challenge
This study is testing a new tuberculosis (TB) vaccine, ID93/GLA-SE, to see if it's safe and helps the body's immune system. Participants will receive the vaccine and then a very small amount of a weakened TB-like bacteria (BCG) through a vape. Researchers want to see how their bodies react.
United Kingdom - not yet recruiting
Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -
The OXIGENE study looks at blood from people with lung conditions like asthma or pneumonia. It aims to understand how their immune system works during illness and if certain immune cells change over time. This could help develop better ways to diagnose and treat lung diseases in the future.
Germany - recruiting
Sputum-free Diagnostis of TB
This study looks for new ways to diagnose tuberculosis (TB) using samples like blood and urine, especially for people who can't cough up spit. It aims to find easier, less invasive tests. Participating involves providing samples once.
Germany - active not recruitingNA
BCG Revaccination Study in Diabetic and Non-Diabetic Adults
This study looks at how to make the BCG vaccine for tuberculosis (TB) work better. We want to see if breathing it in works better than injections. We are also checking if there are differences in how people with and without Type 2 Diabetes respond to the vaccine.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
A randomised, prospective phase II study of pharmacokinetics and safety aspects of higher doses of rifampicin and pyrazinamide in a shortened treatment of mild-to-moderate tuberculosis compared with standard of care
This study is looking at new ways to treat mild to moderate tuberculosis (TB). Researchers are testing if higher doses of two existing medicines, rifampicin and pyrazinamide, can make treatment shorter and just as safe as current treatments. This could help people with TB get better faster.
Sweden - not yet recruiting
Development of the Drug and Alcohol Respiratory Health Test
This study is creating a simple test to check lung health in adults who use certain substances. Many people with substance use disorder have breathing problems that often go unnoticed. This new test aims to find these issues early so people can get the right help.
United Kingdom