- recruitingPHASE3
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
This study looks at combining two medicines, mirikizumab and tirzepatide, for adults with ulcerative colitis (UC) who are also overweight or obese. The goal is to see if this combination helps UC symptoms improve and also leads to significant weight loss.
United States · Austria · Belgium - active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, 2-part, placebo-controlled study to evaluate the efficacy, safety, and PK of PF-07054894 in participants with mild to severe UC.
This study is testing a new medicine called PF-07054894 for people with ulcerative colitis. It will check if the medicine is safe, how well it works, and how the body uses it, compared to a dummy pill.
Germany · Poland - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Learn How Different Amounts and Forms of the Study Intervention Called PF-07899895 are Tolerated and Act in the Body of Healthy Adults
This study is looking at a new medicine called PF-07899895 to see how well healthy adults tolerate it and how it works in their bodies. This is the first time it's being given to people.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Multicenter, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, JNJ-77242113, for people in the UK with moderate to severe ulcerative colitis. We want to see if it helps reduce symptoms and if it's safe compared to a dummy pill.
Czechia · Spain · Poland - active not recruitingPHASE3
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
This study is looking at a medicine called tofacitinib for children aged 2-17 with a bowel condition called ulcerative colitis. It aims to see how well it works, how safe it is, and how the body uses it, especially if other treatments haven't worked.
United States · Australia · Belgium - recruitingPHASE3
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
This study is looking at a medicine called risankizumab for children and young people with ulcerative colitis (UC). It aims to see how well and safely it works, and how it moves through the body, for those aged 2 to 17 with moderate to severe UC.
United States · Belgium · Brazil - authorisedTherapeutic confirmatory (Phase III)
FirST lines of biologics in pAtients with ulceRaTivE colitis: a Randomised controlled trial
This study is comparing different medicines for ulcerative colitis. It aims to find out which new treatments work best to help people feel better and get their symptoms under control. We're looking at things like stopping bleeding and improving bowel habits over time.
France - authorisedTherapeutic use (Phase IV)
Switching to Mesalazine Monotherapy vs Continuing Thiopurines in Older Patients with Ulcerative Colitis in Sustained Remission: A Multicenter Randomized Controlled Trial (IDEA).
This study compares two ways to manage ulcerative colitis in older patients who are feeling well: continuing their usual medicine (thiopurines) or switching to a different one (mesalazine). It checks which approach is better at keeping the condition stable.
Spain - recruiting
Pregnancy and Inflammatory Bowel Disease
This study looks at how inflammatory bowel disease (IBD) affects pregnancy and how pregnancy affects IBD. We're studying women with Crohn's disease or ulcerative colitis who have been pregnant, aiming to understand symptoms during pregnancy and after birth.
France - recruitingPHASE3
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
This study is looking at a new medicine called filgotinib for children and teenagers aged 8 to 18 with moderate to severe ulcerative colitis. It aims to see how well it works, if it's safe, and how the body handles it, compared to what we already know about its use in adults.
Belgium · Croatia · France - recruitingPHASE4
Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis
This study looks at how certain medicines for ulcerative colitis affect your heart and blood vessels. Researchers want to see if drugs like anti-TNF, vedolizumab, and tofacitinib change things like blood vessel stiffness or thickness over time.
France - active not recruitingPHASE2, PHASE3
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called guselkumab for people with ulcerative colitis that isn't well-controlled. We want to see if it helps reduce symptoms and if it's safe to use for those with moderate to severe forms of the condition.
United States · Argentina · Australia - active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
This study is looking into a new treatment called Rosnilimab for people in the UK with moderate to severe ulcerative colitis. It aims to see how safe and effective it is compared to a dummy treatment.
United States · Austria · Bulgaria - active not recruitingPHASE3
Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis
This study looks at the long-term safety of a medicine called filgotinib for adults with ulcerative colitis. It's for people who have already been in another filgotinib study. The main goal is to see if taking filgotinib over a longer time is safe.
United States · Argentina · Australia - recruiting
Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study
This study looks at using robotic surgery for inflammatory bowel disease (IBD) like Crohn's disease and ulcerative colitis. Researchers want to see if robots can help surgeons operate more effectively and how this new method compares to traditional keyhole surgery for IBD.
United Kingdom - active not recruitingPHASE2
A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
This study looks at a new medicine called lutikizumab for adults with moderate to severe ulcerative colitis. It aims to see if it's safe and how well it works compared to a common treatment called adalimumab.
United States · Australia · Austria - recruitingPHASE4
A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)
This study looks at combining two medicines, vedolizumab and tofacitinib, for adults with moderate to severe ulcerative colitis. We want to see if this combination helps more than vedolizumab alone, especially for people who haven't responded well to other treatments.
United States · Canada - ongoing, recruitingTherapeutic use (Phase IV)
(A)nalysis of immunological (VA)riables in ex vivo (T)ofacitinib-treated human biopsies from (A)ctive ulcerative colitis patients to predict clinical (R)esponse (the AVATAR study).
This study looks at how a medicine called Xeljanz (tofacitinib) affects cells from people with ulcerative colitis. Researchers want to understand if these early changes can help predict which patients will get better with this treatment.
Italy - authorisedTherapeutic exploratory (Phase II)
The efficacy of oral vancomycin therapy in managing different phenotypes of paediatric inflammatory bowel diseases by correlating treatment response to commensal microbiota composition and function (VERDA)
This study looks at how a medicine called vancomycin helps children with ulcerative colitis. Researchers want to see if it makes children better and how it affects the gut's tiny living things (microbes) to help discover new treatment options for children with this condition.
Finland - recruitingNA
Personalized Anti-Inflammatory Fibres in Ulcerative Colitis
This study looks into how special fibre supplements, acacia gum and microcrystalline cellulose, affect inflammation in people with ulcerative colitis. Researchers want to see if these fibres can help reduce gut inflammation compared to a dummy treatment.
Canada - active not recruiting
Describing Treatment Patterns and Creating an Updated Treatment Flow in an Ulcerative Colitis Population
This study looks at how treatments for ulcerative colitis have changed over time and how they affect people's health. It's about understanding which treatments work best for long-term health in people with poorly controlled ulcerative colitis.
United Kingdom - recruiting
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
This study looks at whether gut bacteria in people with Crohn's and ulcerative colitis cause ongoing tummy pain, even when their condition is calm. They want to find out if certain fats produced by these bacteria, called LPC and LPA, are the culprits.
Canada - ongoing, recruitingPhase III and phase IV (Integrated)
Unravelling intestinal fibrosis in ulcerative colitis: INTERACT study
This study, called INTERACT, is for people with ulcerative colitis. Researchers are looking at how certain changes in the body are linked to scarring in the gut. They are testing a special scan and looking at cell changes to understand and track this scarring, hoping to find better ways to treat it.
Netherlands - active not recruitingNA
OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
This study, called MEND, aims to see if a special plant-based fibre, called resistant starch, can help children and teenagers with Inflammatory Bowel Disease (IBD). We want to find out if it can make their gut healthier and tackle the root cause of their condition.
Canada - recruiting
A Retrospective Study to Evaluate Treat-to-Target and Disease Modification in Adult Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting
This study looks back at medical records of adults in the UK with Crohn's disease or ulcerative colitis. It aims to see how well a 'treat-to-target' approach helps manage these conditions and if it leads to better long-term health outcomes for patients.
China · France - active not recruitingPHASE3
ABTECT - Maintenance
This study looks at a new drug, ABX464, for people with ulcerative colitis. It's for those who haven't responded well to other treatments. The study checks if ABX464 can help keep symptoms under control over a long time and if it is safe to use.
United States · Argentina · Australia - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Adipose-derived mesenchymal stem cells as local treatment of ulcerative colitis
This study is looking at a new way to treat ulcerative colitis using special cells from fat tissue. Doctors want to see if injecting these cells into the inflamed area can help calm down the gut and reduce symptoms. It's an early-stage study to check safety and how well it works.
Denmark - not yet recruiting
Spondylo-arthritis Screening Tool Among Patient Suffering From Inflammatory Bowel Disease
This study is translating two questionnaires from English to French. These questionnaires help doctors identify if people with inflammatory bowel disease might also have a type of arthritis called spondyloarthritis, so they can get the right care.
France - active not recruitingPHASE3
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
This study looks at the long-term effects and safety of a drug called mirikizumab for people with moderate to severe ulcerative colitis. It can last up to three years, with a chance to continue treatment afterward.
United States · Argentina · Australia - active not recruitingPHASE3
Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.
This study looks at a medicine called Upadacitinib for children and young people aged 2-17 with moderate to severe ulcerative colitis. It aims to see how safe and effective the medicine is, how it works in the body, and if it helps reduce symptoms.
United States · Australia · Belgium - recruiting
Study of Oral Upadacitinib to Assess Change in Disease Activity in Adult Participants With Ulcerative Colitis
This study looks at how well the drug upadacitinib (RINVOQ) works for adults with ulcerative colitis in real-world settings. It follows people already prescribed the medication by their doctors in Germany, Austria, and Switzerland for up to two years.
Austria · Germany · Switzerland - recruitingPHASE3
Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis
This study is looking at new treatments for Ulcerative Colitis. We're testing if special capsules made from healthy donor stool can help people with active Ulcerative Colitis feel better. It involves comparing these capsules to a dummy pill to see if they are safe and effective.
Germany - recruitingPHASE4
Bowel Preparation for Colonoscopy Among Individuals With Crohn's and Ulcerative Colitis Disease.
This study compares two bowel preparations, KleanLyte and Bi-PegLyte, for colonoscopies in people with Crohn's disease or ulcerative colitis. It aims to find out which is more effective at cleaning the bowel and easier to use before a colonoscopy.
Canada - ongoing, recruitingTherapeutic confirmatory (Phase III)
Evaluating the efficacy and safety of hyperbaric oxygen therapy as an adjuvant treatment compared to biologic therapy alone in moderate to severe ulcerative colitis in adults
This study is looking at a new way to treat severe ulcerative colitis. It tests if adding oxygen therapy to existing biologic medicines works better than biologics alone to reduce symptoms like diarrhoea and blood in your poo, and improve gut healing.
Poland - recruitingPHASE2
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
This study is looking into new medicines, Eltrekibart and Mirikizumab, for adults with moderate to severe ulcerative colitis. Researchers want to see if these medicines are safe and if they can help people feel better.
United States · Argentina · Belgium - recruitingPHASE2
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
This study is testing new long-acting medicines for adults with moderate to severe ulcerative colitis. It aims to see how well they work and if they are safe, both on their own and in combinations, compared to a dummy treatment.
United States · Argentina · Australia - recruitingNA
Evaluation of Sleep Changes in Inflammatory Bowel Diseases (IBD) Patients.
This study looks at how sleep changes in people with Inflammatory Bowel Diseases (IBD) who are currently feeling well. We want to see if changes in sleep patterns might predict when their IBD symptoms could return or 'flare up'.
France - recruitingPHASE2
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
This study is testing a new medication, Tilpisertib Fosmecarbil, for adults with moderate to severe ulcerative colitis. It aims to see if the drug is safe and effective compared to a dummy pill (placebo) in improving symptoms.
United States · Australia · Austria - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Clinical Trial to Assess the Safety of SOR102 in Healthy Participants and Patients with Ulcerative Colitis
Researchers are testing a new medicine called SOR102 for ulcerative colitis. This first study checks if it's safe in healthy people and those with the condition. It's an early step to see how SOR102 works in the body and if it could help patients in the future.
Bulgaria · Poland - recruitingPhase III
Study evaluating the efficacy of icotrokinra in ulcerative colitis
This study is testing a new medicine, icotrokinra, for ulcerative colitis (UC) in adults and teenagers. It aims to see if icotrokinra can help reduce UC symptoms and keep the disease under control by targeting inflammation.
United Kingdom · England · Scotland - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Open-Label Study to Assess the Efficacy, Safety, and Pharmacokinetics of Golimumab Treatment, a Human anti-TNFα Monoclonal Antibody, Administered Subcutaneously in Pediatric Participants with Moderately to Severely Active Ulcerative Colitis
This study is looking at a medicine called Simponi for children and teenagers with a gut condition called ulcerative colitis. It wants to see if Simponi can help them feel better and heal their gut, and if it's safe to use.
Poland · France · Italy - ongoing, recruitingTherapeutic use (Phase IV)
VERDICT: In actiVE ulcerative colitis, a RanDomIzed Controlled Trial for determination of the optimal treatment target
This study, called VERDICT, looks at how best to treat ulcerative colitis. It compares different treatment goals using Entyvio, a common medication. The main aim is to see which treatment approach helps patients avoid colitis-related problems for the longest time.
Italy · Belgium · France - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multi-Center, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Induction Therapy with PRA023 in Subjects with Moderately to Severely Active Ulcerative Colitis
This study is looking into a new medicine called tulisokibart for people aged 18 and over with moderate to severe ulcerative colitis. It aims to see if the medicine is safe and helps to reduce symptoms like stomach pain and bleeding, compared to a dummy treatment.
Czechia · Poland · France - ongoing, recruitingTherapeutic use (Phase IV)
A Prospective, Open-label Pilot Study to Evaluate Effector Mechanisms of Hyperbaric Oxygen Therapy in Patients with Moderate-to-Severe Ulcerative Colitis: The PARADOX study
This study, called PARADOX, investigates hyperbaric oxygen therapy (HBOT) for moderate-to-severe ulcerative colitis. Researchers want to understand how HBOT works at a very detailed level, looking at blood, gut lining, and gut bacteria to see if it helps reduce inflammation and symptoms.
Netherlands - active not recruitingPHASE3
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
This study is an extension for people in the UK with moderately to severely active ulcerative colitis who have already taken part in a specific etrasimod trial. It aims to gather more information on the long-term safety and effectiveness of etrasimod for this condition.
United States · Argentina · Australia - recruitingPHASE3
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
This study looks at the long-term safety of a medicine called vedolizumab for children and young people with Crohn's disease or ulcerative colitis. It's for those who have already taken part in a previous study with vedolizumab.
United States · Australia · Belgium - authorisedTherapeutic exploratory (Phase II)
Debut of Ulcerative Colitis: selective Top-down strategy - the DUCT trial
This study looks at a new way to treat ulcerative colitis, a bowel condition. Researchers are testing if giving a specific drug early could help more people achieve 'deep remission' and avoid surgery or other strong medications in the first year after diagnosis.
Norway - authorisedHuman Pharmacology (Phase I)- Bioequivalence Study
An open label, balanced, randomized, two-treatment, four-period, two-sequence, single-dose, crossover fully replicate bioequivalence study comparing Mesalamine delayed release capsules 400 mg manufactured by Sun Pharmaceutical Industries Limited, India with Mesalamine Delayed-Release Capsules 400 mg, manufactured for Teva Pharmaceuticals USA, Inc. Parsippany, NJ 07054, in healthy, adult, human subjects under fed condition.
This study compares two different brands of mesalamine capsules, a medicine for ulcerative colitis, in healthy adults. It checks if they work the same way in the body after a single dose, under fed conditions.
Romania - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study to evaluate food effect on the pharmacokinetics of mesalazine oral formulation in healthy volunteers.
This study is looking at how a common medicine for ulcerative colitis, called mesalazine, is absorbed by the body when taken with food. It involves healthy volunteers and aims to help us understand the best way to take this medication.
Spain