- recruitingNA
Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.
This study compares two common surgeries to reconnect your gut after removing most of your large bowel for Ulcerative Colitis. It aims to see which one, an ileal pouch or an ileorectal anastomosis, offers the best quality of life, satisfaction, and fewer complications for patients in the UK.
Sweden · United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A single arm, open-label study to evaluate the efficacy and safety of ABBV-668 in subjects with moderate to severe ulcerative colitis.
This study is testing a new medicine called ABBV-668 for people with moderate to severe ulcerative colitis. Doctors want to see if it helps improve the lining of the bowel after 8 weeks and if it's safe to use. It's a key step in understanding if this medicine could help patients.
Belgium · France · Poland - active not recruitingPHASE3
A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
This study is testing a new medicine, tulisokibart, for people with moderate to severe ulcerative colitis. It aims to see if the medicine can help people feel better and stay in remission, compared to a dummy medicine, both in the short and long term.
United States · Argentina · Australia - authorisedTherapeutic exploratory (Phase II)
T-FORE - Pilot study of a new technique of Oral Fecal Transplantation using frozen stool capsules for the maintenance treatment of pediatric Ulcerative Colitis (UC)
This study looks at a new way to treat Ulcerative Colitis in children using healthy gut bacteria from donor stool. They are testing both capsules and enemas to see which method works best to improve the gut’s natural balance over time.
France - active not recruiting
Prospective Observational Study of Effectiveness and Safety of Filgotinib in Participants With Ulcerative Colitis (UC)
This study looks at how a medicine called filgotinib works for people with ulcerative colitis in everyday life. Researchers want to see if it helps with symptoms, improves quality of life, and if it's safe for people with moderate to severe disease.
Austria · Belgium · France - authorisedHuman Pharmacology (Phase I)- Bioequivalence Study
A double blinded, balanced, randomized, two-treatment, four-period, two-sequence, single-dose, crossover fully replicate bioequivalence study comparing Mesalamine Delayed Release Tablets USP 1.2 g manufactured by Sun Pharmaceutical Industries Limited, India with Mezavant (mesalamine) Delayed and Extended-Release Tablets 1.2 g product of Takeda Canada Inc., in healthy, adult, human subjects under fed condition.
This study compares a new version of Mesalamine, a medicine for ulcerative colitis, with an existing one. We want to see if the new version works in the body in the same way as the old one, in healthy adults who have eaten.
Romania - recruitingPHASE3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
This study looks at a medicine called Mirikizumab for children and teenagers aged 2 to 19 with Ulcerative Colitis or Crohn's Disease. It checks how well the medicine works over a long time to help manage these conditions.
United States · Austria · Belgium - recruitingPHASE3
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
This study is looking at a medicine called risankizumab for children and young people with ulcerative colitis (UC). It aims to see how well and safely it works, and how it moves through the body, for those aged 2 to 17 with moderate to severe UC.
United States · Belgium · Brazil - recruitingPHASE3
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
This study looks at combining two medicines, mirikizumab and tirzepatide, for adults with ulcerative colitis (UC) who are also overweight or obese. The goal is to see if this combination helps UC symptoms improve and also leads to significant weight loss.
United States · Austria · Belgium - active not recruitingPHASE3
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
This study is an extension for people in the UK with moderately to severely active ulcerative colitis who have already taken part in a specific etrasimod trial. It aims to gather more information on the long-term safety and effectiveness of etrasimod for this condition.
United States · Argentina · Australia - ongoing, recruitingTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Multicenter Phase 2 Induction Study with Long-Term Extension to Evaluate the Clinical Activity and Safety of Oral NX-13 in Participants with Moderate to Severe Ulcerative Colitis
This study is testing a new medicine called NX-13 for people in the UK with moderate to severe ulcerative colitis. Researchers want to see if it helps reduce symptoms and is safe compared to a dummy pill.
Belgium · Poland · Italy - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multi-Center, Open-Label Study of the Human Anti-TNF Monoclonal Antibody Adalimumab to Evaluate Long-Term Safety and Tolerability of Repeated Administration of Adalimumab in Pediatric Subjects with Ulcerative Colitis Who Completed the Study M11-290
This study looks at the long-term safety of a treatment called Humira for children and teens with ulcerative colitis. It's for those who have already been on Humira in a previous study. We want to see how well they continue to do.
Slovakia · Poland - recruiting
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
This study compares body markers linked to inflammation in people with Crohn's disease or ulcerative colitis (IBD) and healthy individuals. It aims to understand IBD better and find ways to predict treatment responses, ultimately leading to improved care.
United Kingdom - active not recruitingPHASE2
Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called emvistegrast for people with moderate to severe ulcerative colitis. It aims to see if emvistegrast can help improve their symptoms compared to a dummy medicine.
United States · Australia · Austria - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Ulcerative Colitis
This study is testing a new medicine called Rosnilimab for people with moderate to severe Ulcerative Colitis. Researchers want to see if it helps reduce symptoms and improve gut health compared to a dummy treatment, and if it's safe to use.
France · Germany · Austria - recruitingPHASE2
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
This study is looking into a new treatment, RO7837195, for people with moderate to severe ulcerative colitis whose usual treatments haven't worked well. It aims to see if the new drug is safe and effective in helping manage the condition.
United States · Australia · Brazil - active not recruiting
An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice
This study looks at how a medicine called upadacitinib works for adults with moderate to severe Ulcerative Colitis in everyday life. Researchers will check its safety and how well it helps manage the condition, following about 1000 people over three years.
Argentina · Australia · Canada - ongoing, recruitingTherapeutic exploratory (Phase II)
Orismilast for the treatment of moderate to severe ulcerative colitis
This study is looking into a new medicine called Orismilast for people in the UK with moderate to severe ulcerative colitis. It's a Phase II trial, meaning it's still in the earlier stages of testing. Researchers want to see if the medicine can help people feel better by reducing symptoms.
Denmark - authorisedTherapeutic exploratory (Phase II)
Multi-center, single-arm, phase II clinical trial evaluating efficacy and in-vivo homing of adoptively transferred autologous ex-vivo expanded regulatory T cells in adults with ulcerative colitis
This study is testing a new cell therapy for adults with ulcerative colitis. It involves taking your own immune cells, growing more of them in a lab, and then giving them back to you. Researchers want to see if this helps reduce symptoms within 12 weeks.
Germany - active not recruitingPHASE3
A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called mirikizumab for adults with ulcerative colitis. It aims to see how well it helps reduce urgent bowel movements in people with moderate to severe disease, especially if other treatments haven't worked.
United States · Belgium · Czechia - recruitingPHASE2
A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis
This study is testing a new drug, SAR442970, for adults with moderate to severe Ulcerative Colitis. It compares different doses of the drug to a dummy pill to see if it helps reduce symptoms and is safe.
United States · Australia · China - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1b, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Safety, Engraftment, and Initial Signs of Clinical Activity of MB310 in Patients with Active, Mild to Moderate Ulcerative Colitis (COMPOSER-1)
This study is looking into a new treatment called MB310 for people with ulcerative colitis. It's an early-stage trial checking if the treatment is safe, how well it settles in the body, and if it shows any early signs of helping patients with mild to moderate symptoms.
Austria · Poland · Bulgaria - active not recruitingPHASE2
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Ulcerative Colitis
This study looks at a new medicine called TAK-279 for adults with moderate to severe ulcerative colitis. It aims to see if it reduces bowel inflammation and symptoms compared to a dummy medicine, and to check for any side effects.
United States · Australia · Belgium - active not recruitingPHASE2, PHASE3
A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called guselkumab for people with ulcerative colitis that isn't well-controlled. We want to see if it helps reduce symptoms and if it's safe to use for those with moderate to severe forms of the condition.
United States · Argentina · Australia - recruitingPHASE2
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
This study is testing a new medicine called MK-8690 for people with moderate to severe ulcerative colitis. Researchers want to see if it's better than a dummy medicine (placebo) at helping people feel better and achieve remission.
United States · Colombia · France - active not recruitingPHASE2
A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
This study looks at a new medicine called lutikizumab for adults with moderate to severe ulcerative colitis. It aims to see if it's safe and how well it works compared to a common treatment called adalimumab.
United States · Australia · Austria - active not recruitingPHASE3
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
This study is looking at a medicine called tofacitinib for children aged 2-17 with a bowel condition called ulcerative colitis. It aims to see how well it works, how safe it is, and how the body uses it, especially if other treatments haven't worked.
United States · Australia · Belgium - active not recruitingPHASE3
A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)
This study looks at the long-term effects and safety of a drug called mirikizumab for people with moderate to severe ulcerative colitis. It can last up to three years, with a chance to continue treatment afterward.
United States · Argentina · Australia - active not recruitingPHASE3
Filgotinib in Long-Term Extension Study of Adults With Ulcerative Colitis
This study looks at the long-term safety of a medicine called filgotinib for adults with ulcerative colitis. It's for people who have already been in another filgotinib study. The main goal is to see if taking filgotinib over a longer time is safe.
United States · Argentina · Australia - recruitingPHASE3
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
This study looks at the long-term safety of a medicine called vedolizumab for children and young people with Crohn's disease or ulcerative colitis. It's for those who have already taken part in a previous study with vedolizumab.
United States · Australia · Belgium - recruitingPHASE2
Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative Colitis
This study is testing a new medication, Tilpisertib Fosmecarbil, for adults with moderate to severe ulcerative colitis. It aims to see if the drug is safe and effective compared to a dummy pill (placebo) in improving symptoms.
United States · Australia · Austria - active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, 2-part, placebo-controlled study to evaluate the efficacy, safety, and PK of PF-07054894 in participants with mild to severe UC.
This study is testing a new medicine called PF-07054894 for people with ulcerative colitis. It will check if the medicine is safe, how well it works, and how the body uses it, compared to a dummy pill.
Germany · Poland - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Learn How Different Amounts and Forms of the Study Intervention Called PF-07899895 are Tolerated and Act in the Body of Healthy Adults
This study is looking at a new medicine called PF-07899895 to see how well healthy adults tolerate it and how it works in their bodies. This is the first time it's being given to people.
Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Multicenter, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of JNJ-77242113 for the Treatment of Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, JNJ-77242113, for people in the UK with moderate to severe ulcerative colitis. We want to see if it helps reduce symptoms and if it's safe compared to a dummy pill.
Czechia · Spain · Poland - authorisedTherapeutic confirmatory (Phase III)
FirST lines of biologics in pAtients with ulceRaTivE colitis: a Randomised controlled trial
This study is comparing different medicines for ulcerative colitis. It aims to find out which new treatments work best to help people feel better and get their symptoms under control. We're looking at things like stopping bleeding and improving bowel habits over time.
France - authorisedTherapeutic use (Phase IV)
Switching to Mesalazine Monotherapy vs Continuing Thiopurines in Older Patients with Ulcerative Colitis in Sustained Remission: A Multicenter Randomized Controlled Trial (IDEA).
This study compares two ways to manage ulcerative colitis in older patients who are feeling well: continuing their usual medicine (thiopurines) or switching to a different one (mesalazine). It checks which approach is better at keeping the condition stable.
Spain - recruiting
Pregnancy and Inflammatory Bowel Disease
This study looks at how inflammatory bowel disease (IBD) affects pregnancy and how pregnancy affects IBD. We're studying women with Crohn's disease or ulcerative colitis who have been pregnant, aiming to understand symptoms during pregnancy and after birth.
France - recruitingPHASE3
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
This study is looking at a new medicine called filgotinib for children and teenagers aged 8 to 18 with moderate to severe ulcerative colitis. It aims to see how well it works, if it's safe, and how the body handles it, compared to what we already know about its use in adults.
Belgium · Croatia · France - recruitingPHASE4
Impact of Anti-TNF, Vedolizumab and Tofacitinib on Aortic Stiffness, Carotid Intima-media Thickness and Cardiovascular Risk of Patients With Ulcerative Colitis
This study looks at how certain medicines for ulcerative colitis affect your heart and blood vessels. Researchers want to see if drugs like anti-TNF, vedolizumab, and tofacitinib change things like blood vessel stiffness or thickness over time.
France - active not recruitingPHASE2
A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
This study is looking into a new treatment called Rosnilimab for people in the UK with moderate to severe ulcerative colitis. It aims to see how safe and effective it is compared to a dummy treatment.
United States · Austria · Bulgaria - recruiting
Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study
This study looks at using robotic surgery for inflammatory bowel disease (IBD) like Crohn's disease and ulcerative colitis. Researchers want to see if robots can help surgeons operate more effectively and how this new method compares to traditional keyhole surgery for IBD.
United Kingdom - recruitingPHASE4
A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)
This study looks at combining two medicines, vedolizumab and tofacitinib, for adults with moderate to severe ulcerative colitis. We want to see if this combination helps more than vedolizumab alone, especially for people who haven't responded well to other treatments.
United States · Canada - ongoing, recruitingTherapeutic use (Phase IV)
(A)nalysis of immunological (VA)riables in ex vivo (T)ofacitinib-treated human biopsies from (A)ctive ulcerative colitis patients to predict clinical (R)esponse (the AVATAR study).
This study looks at how a medicine called Xeljanz (tofacitinib) affects cells from people with ulcerative colitis. Researchers want to understand if these early changes can help predict which patients will get better with this treatment.
Italy - authorisedTherapeutic exploratory (Phase II)
The efficacy of oral vancomycin therapy in managing different phenotypes of paediatric inflammatory bowel diseases by correlating treatment response to commensal microbiota composition and function (VERDA)
This study looks at how a medicine called vancomycin helps children with ulcerative colitis. Researchers want to see if it makes children better and how it affects the gut's tiny living things (microbes) to help discover new treatment options for children with this condition.
Finland - recruitingNA
Personalized Anti-Inflammatory Fibres in Ulcerative Colitis
This study looks into how special fibre supplements, acacia gum and microcrystalline cellulose, affect inflammation in people with ulcerative colitis. Researchers want to see if these fibres can help reduce gut inflammation compared to a dummy treatment.
Canada - active not recruiting
Describing Treatment Patterns and Creating an Updated Treatment Flow in an Ulcerative Colitis Population
This study looks at how treatments for ulcerative colitis have changed over time and how they affect people's health. It's about understanding which treatments work best for long-term health in people with poorly controlled ulcerative colitis.
United Kingdom - recruiting
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
This study looks at whether gut bacteria in people with Crohn's and ulcerative colitis cause ongoing tummy pain, even when their condition is calm. They want to find out if certain fats produced by these bacteria, called LPC and LPA, are the culprits.
Canada - ongoing, recruitingPhase III and phase IV (Integrated)
Unravelling intestinal fibrosis in ulcerative colitis: INTERACT study
This study, called INTERACT, is for people with ulcerative colitis. Researchers are looking at how certain changes in the body are linked to scarring in the gut. They are testing a special scan and looking at cell changes to understand and track this scarring, hoping to find better ways to treat it.
Netherlands - active not recruitingNA
OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
This study, called MEND, aims to see if a special plant-based fibre, called resistant starch, can help children and teenagers with Inflammatory Bowel Disease (IBD). We want to find out if it can make their gut healthier and tackle the root cause of their condition.
Canada