Vascular malfomation research hub

A single arm single center exploratory observational phase II study, aimed to detect long term changes in volume of port-wine macrocheilia and color of port-wine stain in patients undergoing surgery and laser therapy during sirolimus treatment. Quality of life and efficacy and safety of sirolimus will be assessed.

This study looks at whether a medicine called sirolimus helps reduce lip swelling and fade the colour of port-wine birthmarks. Adults having surgery and laser therapy will take sirolimus. Doctors will measure lip size, check skin colour, and assess how treatment improves everyday wellbeing over five years.