- authorisedTherapeutic exploratory (Phase II)
A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of SIR9900 in Patients with VEXAS Syndrome (SIVEX)
This clinical study is testing a new medicine called SIR9900 for people with VEXAS syndrome. Researchers want to see if it is safe and helps control painful inflammation. They also want to find out if it allows patients to safely reduce their daily steroid doses without symptoms flaring up.
Italy - authorisedPhase II and Phase III (Integrated)
A Randomized Phase 2/3, Double-blind, Placebo Controlled Adaptive Study Evaluating the Efficacy and Safety of Momelotinib in Participants with VEXAS Syndrome
This study is testing a tablet called momelotinib for adults with VEXAS syndrome. VEXAS is a rare condition causing severe inflammation and blood problems. Researchers want to find out if momelotinib can calm symptoms, prevent flare-ups, and reduce the need for strong steroid medications compared to a dummy pill.
France - recruitingPHASE2
A Study to Assess the Effectiveness and Safety of Pacritinib in Patients With VEXAS Syndrome (PAXIS)
This study is testing a new drug, pacritinib, for VEXAS syndrome. Researchers want to see if it's safe and helps reduce flare-ups and the need for steroids in people aged 18 and over with VEXAS.
United States · Canada · France - recruiting
AutoInflammatory Disease Alliance Registry (AIDA)
This project is building a secure online registry to collect health information from people with rare inflammatory conditions. The goal is to better understand these diseases, how they affect people, and how different treatments work. Your information could help doctors improve care for others.
Algeria · Australia · Belgium