Latest studies
- CompletedPhase I/II
Platform study Kaleidoscope: A Phase 1/2 Open-label Platform Study to Evaluate the Safety and Efficacy of Multiple Amivantamab-based Therapeutic Combinations in Participants with Advanced, Unresectable Lung Cancer (LC) ISA1 METalmark (now closed in UK): A phase I/II open-label platform study to evaluate the safety and efficacy of multiple amivantamab-based therapeutic combinations in participants with advanced, unresectable lung cancer ISA2 Polydamas: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Cetrelimab Combination Therapy in Metastatic Non-small Cell Lung Cancer ISA3 SwalloWTail: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Docetaxel Combination Therapy in Metastatic Non-small Cell Lung Cancer
This clinical trial tests new combination treatments for advanced non-small cell lung cancer that has spread. Researchers are checking whether combining a targeted drug called amivantamab with other cancer medicines is safe and helps slow cancer growth. Two study branches are currently open for adults at specialist UK cancer hospitals.
Unresectable metastatic non-small cell lung cancerTürkiye - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaTürkiye - RecruitingPhase III
A study of the anti-inflammatory medication colchicine for people with blocked arteries of the legs
Peripheral arterial disease (PAD) causes narrowed blood vessels in the legs. This clinical trial is testing whether an anti-inflammatory tablet called colchicine can help protect arteries and reduce the risk of serious complications, such as heart attacks, strokes, and leg amputations, in people living with PAD.
Peripheral artery diseaseTürkiye - RecruitingPhase III
A randomized, open-label Phase III study of amivantamab and mFOLFOX6 or FOLFIRI versus cetuximab and mFOLFOX6 or FOLFIRI as first-line treatment in participants with KRAS/NRAS and BRAF wild-type unresectable or metastatic left-sided colorectal cancer
This study looks at a new drug called amivantamab for people with advanced bowel cancer on the left side of the colon. Researchers want to see if combining amivantamab with standard chemotherapy works better at slowing down cancer growth than the usual targeted drug, cetuximab, combined with chemotherapy.
Unresectable or Metastatic Left-sided Colorectal CancerTürkiye - Completed
SUPREMO, an MRC Phase III randomised trial to assess the role of adjuvant chest wall irradiation in 'intermediate risk' operable breast cancer following mastectomy
The SUPREMO study looks at whether radiotherapy to the chest wall helps women with intermediate-risk breast cancer after a mastectomy. Researchers want to find out if this treatment stops the cancer from returning, or if it can be safely avoided to spare patients from unnecessary side effects.
Breast cancerTürkiye - CompletedPhase III
Disitamab vedotin with pembrolizumab vs chemotherapy in previously untreated urothelial cancer expressing HER2
This study tests a new medicine combination for people with advanced bladder cancer that carries a protein called HER2. Researchers want to see if combining two drugs, disitamab vedotin and pembrolizumab, works better and helps people live longer than standard chemotherapy.
Previously untreated locally advanced or metastatic urothelial carcinoma that expresses HER2 (IHC 1+ and greater)Türkiye - RecruitingPhase III
A Phase III trial of inhaled mosliciguat in pulmonary hypertension associated with interstitial lung disease
This clinical trial is testing an inhaled medicine called mosliciguat for people with high blood pressure in the lungs caused by lung scarring. Researchers want to see if breathing in this drug helps people walk further over six minutes compared to a dummy inhaler with no active medicine.
Pulmonary hypertension associated with interstitial lung diseaseTürkiye - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaTürkiye - CompletedPhase II
A long-term extension study of JNJ-81201887 (AAVCAGsCD59) parent studies in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
This study looks at the long-term safety of a new gene therapy, JNJ-81201887, for Geographic Atrophy (GA), a severe eye condition. It involves people who previously took part in earlier studies of this treatment, to see how they are doing over several years.
Geographic Atrophy, secondary to age-related macular degenerationTürkiye - RecruitingPhase III
A study of nipocalimab in adults with moderate to severe systemic lupus erythematosus
This study is testing a new drug called nipocalimab for adults with moderate to severe lupus (SLE). Researchers want to see if it works better than a dummy drug to reduce symptoms. It involves regular visits and monitoring over several years.
Systemic lupus erythematosusTürkiye - Recruiting
Improving hormonal infertility treatment for men with hypogonadotropic hypogonadism
This study looks back at records of men with hypogonadotropic hypogonadism, a type of male infertility. Doctors want to find the best hormone treatment to help these men and their partners get pregnant. No new patients are needed for this study.
Infertility due to hypogonadismTürkiye - CompletedPhase I/II
A two-part study to investigate the effects in adults of two doses of golexanolone in patients with primary biliary cholangitis with fatigue and cognitive dysfunction
This study looks at a new drug, golexanolone, for people with a liver condition called Primary Biliary Cholangitis (PBC) who also feel very tired and have trouble thinking clearly. Researchers want to see if it's safe, how it works in the body, and if it helps these symptoms.
Patients with primary biliary cholangitis with fatigue and cognitive dysfunctionTürkiye