- Ongoing, recruitingTherapeutic exploratory (Phase II)
A 12-month, randomized, single-blind, placebo-controlled exposure-response study of TCD601 (siplizumab) in new onset type 1 diabetes patients (STRIDE)
This study is looking into a new treatment for people newly diagnosed with type 1 diabetes. It compares a drug called TCD601 (siplizumab) with a dummy treatment (placebo) over 12 months to see if it can help the body keep making its own insulin.
For: New onset type I diabetesSweden · Belgium · Italy - AuthorisedPhase III and phase IV (Integrated)
(WHAT!) – RCT: Open-label randomized controlled trial for the effects of continuous daily use of ethinylestradiol/levonorgestrel (30/150 µg/day) compared with vitamin E (400 IU/day) in the treatment of menstrually-related migraine and perimenopausal migraine
This study is looking at how two treatments, a common hormone pill (like Microgynon 30) and vitamin E, compare for women who get migraines linked to their period or during menopause. Researchers want to see if these treatments can reduce how often and how severely these migraines happen.
For: MigraineNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Double-blind, Placebo-Controlled, Multicenter Study With an Open-label Extension to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients With Duchenne Muscular Dystrophy
This study is looking at two new medicines, SRP-4045 and SRP-4053, for Duchenne muscular dystrophy. It wants to see if they can help boys with certain types of Duchenne walk better and for longer. The study will compare these medicines to a dummy treatment.
For: Patients with Duchenne Muscular Dystrophy Amenable to Exon 45 or 53 Skipping.Belgium · Ireland · Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A 4-Week, Phase II, Multicenter, Randomized, Double-Masked, Vehicle-Controlled, Parallel Group Study With 2 Weeks of Follow-Up to Evaluate Safety and Efficacy of Two Different Dosages of Isocyclosporin A Eye Drop Solution Versus Vehicle in Adult Patients with Atopic Keratoconjunctivitis (AKC).
This study is testing a new eye drop called Isocyclosporin A for adults with a severe allergic eye condition called Atopic Keratoconjunctivitis (AKC). It aims to see if the drops can reduce itchy eyes and are safe to use.
For: Atopic keratoconjunctivitis (AKC)Italy - Ongoing, recruitingPhase II and Phase III (Integrated)
A Randomized, Double-blind, Placebo-controlled, Phase 2/3 Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Obeticholic Acid Compared to Placebo in Pediatric Subjects with Biliary Atresia, Post-hepatoportoenterostomy
This study is testing a new medicine, obeticholic acid (OCA), for children and young adults with biliary atresia who have had a specific surgery. We want to see if OCA can help slow down liver disease and improve their health.
For: Biliary Atresia · Post-hepatoportoenterostomyBelgium · Germany · Netherlands - AuthorisedPhase III and phase IV (Integrated)
A randomised, controlled, assessor-blind, parallel groups, multicentre, multinational trial comparing the ovarian response after controlled ovarian stimulation with mixed protocols of follitropin delta (REKOVELLE) and highly purified human menopausal gonadotropin (MENOPUR) in women undergoing an assisted reproductive technology programme
This study is looking at two different hormone medicines, Rekovelle and Menopur, used in fertility treatments like IVF. Researchers want to see which one helps women produce more good-quality eggs. It aims to improve chances of pregnancy for women needing fertility help.
For: Infertility in women undergoing assisted reproductive technologies (ART) such as an in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycleItaly · Spain - Ongoing, recruitingPhase III and phase IV (Integrated)
Prospective Randomized trial of Everolimus replacing MMF/MP Acid by the RECOVAC consortium to increase VACcine response in kidney transplant patients
This study looks at how well kidney transplant patients respond to COVID-19 and shingles vaccines when their anti-rejection medication is changed. It compares two different drug treatment plans to see which one helps the body make more protective antibodies.
For: kidney transplantation · COVID-19 · Herpes ZosterNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Evaluation of the efficacy of topical treatment with budesonide in children with Crohn's disease located in the esophagus and/or stomach and/or duodenum - BETHESDa
This study, called BETHESDa, is looking into how well a medicine called budesonide works for children with Crohn's disease that affects their food pipe, stomach, or the first part of their small bowel. They're checking if it can make visible signs of the disease disappear.
For: Crohn's diseasePoland