- Ongoing, recruitingTherapeutic use (Phase IV)
Cerebral neuroinflammation during major depressive episode: multicentric comparative study (InflaDep)
This study looks into how inflammation in the brain might be linked to severe depression. Researchers are using special scans to compare brain inflammation in people with depression to those without. The goal is to better understand depression and find new ways to help treat it.
For: Depressive disorderFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Impact of post-Acute respiratory distress syndrome COVID sedation on late neuroinflammation (PET-DEXDOCOVID)
This study looks at how a medicine called dexmedetomidine might help reduce long-term brain inflammation in COVID-19 patients who were very ill and needed breathing support. It aims to see if this medicine can improve their brain health after leaving intensive care.
For: Patients who survive a COVID ARDS in intensive care must be weaned off invasive mechanical ventilation as quickly as possible. 60% of these patients present with intensive care delirium · a serious event that causes excess mortality and potential acute and late complications · dexmedetomidine has neuroprotective effects. In certain experimental modelsFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
PLAQUE AND BRAIN INFLAMMATION IN SYMPTOMATIC CAROTID STENOSIS: ROLE OF THE FICOLIN-2 STATEMENT
This study looks at how a protein called ficolin-2 in the blood might be linked to brain inflammation and fatty deposits (plaque) in arteries that lead to the brain. Researchers want to understand these links better, especially in people who have had a stroke or mini-stroke.
For: stroke or transient ischemic attackFrance - AuthorisedTherapeutic exploratory (Phase II)
Role of Neuroinflammation and Blood-Brain Barrier Breakdown in Intracerebral Hemorrhage. The INFINITE Study
This study, called INFINITE, looks at how brain inflammation and blood vessel damage might affect recovery after a brain bleed (intracerebral hemorrhage). Researchers use special scans to see these changes and how they link to a person's recovery six months later.
For: Intracerebral hemorrhage.France