5 mg clinical trials

Immediate versus delayed insertion of intrauterine contraception at the time of medical abortion- An open-label, randomized, multicenter study

This study compares when to fit an intrauterine contraceptive (IUC), like a coil, after a medical abortion. It looks at whether fitting it straight away or later works best for women.

A randomized, double blind, placebo-controlled, dose response, phase II, multicentre trial to evaluate the efficacy and safety of oral AP1189 administered at the doses of 40, 70, or 100 mg for 12 weeks in combination with methotrexate, in DMARD-naïve participants with early rheumatoid arthritis and active inflammation.

This study is testing a new tablet, AP1189, for people recently diagnosed with rheumatoid arthritis who haven't tried other strong medicines yet. It aims to see how well different doses of AP1189 lower inflammation and improve symptoms when taken with another common arthritis medicine.

A phase 2, open label, multicenter, single-stage study to evaluate the efficacy of Isatuximab plus Pomalidomide and Dexamethasone (IPd), in patients with AL amyloidosis not in VGPR or better after any previous therapy

This study is testing a new combination of medicines for people with AL amyloidosis. It looks at how well the new treatment works and if it helps improve the disease, especially for those who haven't responded well to previous treatments.

MInimal residual Disease Adapted Strategy / IFM 2020-02: frontline therapy for patients eligible for autologous stem cell transplantation less than 66 years; a prospective study from the French cooperative group IFM

This study is looking at new ways to treat multiple myeloma, a type of blood cancer, in people under 66. It's testing if different treatment plans can better reduce the cancer to very low levels before further treatment. The aim is to find out which approaches work best for patients.

Does Colchicine Reduce Progression of Aortic Valve Stenosis? Colchicine and Inflammation in Aortic Stenosis (CHIANTI): A placebo-controlled, double-blind, multicenter randomized trial.

This study looks at whether a widely used medicine called colchicine can slow down the hardening of the heart's aortic valve. Researchers will compare people taking colchicine with those taking a dummy pill, to see if it helps keep the valve working better for longer. It's a big study to find out if this treatment could be useful.

Pulmonary REsistance modification under treatment with Sacubitil/valsartaN in paTients with HeartFailure with reduced ejection fraction

This study looks at how a drug called Entresto affects blood pressure in the lungs and how easily blood flows through them, in people with a type of heart failure where the heart struggles to pump blood.

Comparative study of eplerenone-based treatment strategy versus irbesartan-based blood pressure lowering in obese hypertensive patients (HEBRO Study)

This study compares two common strategies for lowering blood pressure in obese patients. It looks at whether treatments based on eplerenone or irbesartan are better at controlling blood pressure over 24 weeks. The aim is to find effective ways to manage high blood pressure in this group.

SABINE - The efficacy and Safety of delayed-release Budesonide in children with primary IgA nephropathy - a multicenter, interventional phase III, randomized, placebo-controlled, double-blind study.

This study looks at a new way to treat a kidney condition called IgA nephropathy in children. It compares a special medicine (budesonide) with a dummy medicine (placebo) to see if it can help reduce protein in the urine and is safe.

Efficacy of non operative treatment with amoxicillin/clavulanic acid versus surgical treatment in acute uncomplicated appendicitis in children: a prospective multicenter randomized controlled non-inferiority trial with cost utility analysis

This study is comparing two ways to treat appendicitis in children: surgery versus antibiotics. Researchers want to see if antibiotics work just as well as surgery, and what the overall costs and effects are for families.

ANTIBIOBONTA - Assessment of the interest of a peri-operative antibiotic strategy applied to patients with asymptomatic bacteriuria undergoing intra-vesical botulinum toxin A injections

This study looks at whether antibiotics before and after bladder botulinum toxin A injections can prevent urine infections. It's for adults with bladder problems from multiple sclerosis or spinal cord injury, who also have bacteria in their urine without symptoms.

Methotrexate in paediatric and adolescent Crohn’s disease: an observational study

This study looks at how well a medicine called methotrexate works for young people with Crohn's disease over a year. It checks how much of the medicine stays in the body and if patients need to stop using it due to side effects or if it's not helping enough.

Phase I study of CDK8 inhibitor RVU120 in combination with everolimus in children with recurrent or progressive Group 3 or 4 medulloblastoma; MEDWAY

This study, called MEDWAY, is looking at a new medicine, RVU120, alone and with another drug, everolimus. It's for children with a type of brain cancer called medulloblastoma that has come back or is getting worse. We want to find the safest dose and see how well it works.

MERCURE study: MEthotrexate in ReCurrent dVIN

This study looks at whether a medicine called methotrexate can help women with a skin condition called dVIN, linked to lichen sclerosus, stop it from coming back. It compares if dVIN returns less often when women take methotrexate versus when they don't.

Prospective Randomized trial of Everolimus replacing MMF/MP Acid by the RECOVAC consortium to increase VACcine response in kidney transplant patients

A randomized, open-label, single dose, cross-over bioavailability study evaluating the drug-drug interaction between Tritace 10, 10 mg, tablets and Tertensif SR 1.5 mg prolonged-release film-coated tablets when co-administered versus the administration of each product alone in two cohorts of healthy volunteers under fasting conditions. Sponsor's Study No.: RAM-IND-DDI-05-23

A 12-Month, Randomized, Controlled, Open-Label, Dose Escalation Study Evaluating Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of an Anti-CD2 Monoclonal Antibody, TCD601(siplizumab) Compared to Anti-Thymocyte Globulin (rATG), as Induction Therapy in de novo Renal Transplant Recipients

Early ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy

A stratification trial to determine key immunological factors predicting Tofacitinib efficacy in Psoriatic Arthritis (PsA); TOFA-PREDICT

VASCULAR AND RENAL IMPACT OF ENDOTHELIN-1 RECEPTOR BLOCKADE IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION - ENDOTHELIN-2