- AuthorisedTherapeutic exploratory (Phase II)
A phase II efficacy and safety study of cell-free circulating tumor DNA-guided commencement of second-line treatment in patients with DLBCL/HGBCL relapse
This study looks at new ways to decide when to start a second treatment for certain types of lymphoma, using a blood test. It aims to see if this approach is safe and effective in helping patients.
For: Diffuse large B-cell lymphomas (DLBCL · Diffuse large B-cell lymphoma) and aggressive B-cell lymphomas (HGBCL · High-grade B-cell lymphoma) originate from mature B-cells at various stages of terminal differentiationPoland - AuthorisedTherapeutic confirmatory (Phase III)
LEONARD.LEvOsimendaN vs. Placebo Before Tricuspid VAlve Surgery in Patients with Right Ventricular Dysfunction (LEONARD)
This study is looking at whether a drug called levosimendan can help patients undergoing heart surgery for a leaky heart valve. It aims to see if this medicine can reduce serious problems like low heart output in the first 90 days after surgery.
For: Patients referred for an isolated or a combined surgical correction of functional moderate to severe tricuspid regurgitationFrance - Ongoing, recruitingTherapeutic use (Phase IV)
The Intertransverse Process Block - Single or Multiple Injection? A randomised, procedure related, blinded crossover trial in healthy volunteers
This study is looking at a pain-relief method called an 'Intertransverse Process Block' in healthy men. Researchers are comparing one injection to multiple injections to see which works better for numbing areas of the chest. It's about finding the best way to help with pain, especially after breast cancer surgery.
For: The ITP block is primarily used for pain amelioration after breast cancer surgery.Denmark - Ongoing, recruitingTherapeutic use (Phase IV)
Efficacy of Intrathecal Morphine for Postoperative Analgesia with or without Suprainguinal Fascia Iliaca Block After Total Hip Arthroplasty: A Double-Blind Randomized Clinical Trial
This study looks at how well different pain relief methods work after hip replacement surgery, focusing on a strong painkiller given near the spine, sometimes with another pain relief injection. It aims to find the best way to manage pain and help people recover quickly.
For: Total hip arthroplasty under spinal anesthesiaBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Placebo-Controlled Multicenter Study of Levosimendan Therapy in low ejection fraction Takotsubo Syndrome (LevoTako Trial)
The LevoTako trial looks at a medicine called Levosimendan for people with a temporary heart condition called Takotsubo Syndrome. It's a large study to see if this medicine helps the heart recover faster while in the hospital.
For: Takotsubo syndromePoland - AuthorisedTherapeutic use (Phase IV)
Comparison of morphine and alfentanil in the emergency treatment of severe acute pain in the pre-hospital setting
This study compares two pain medications, morphine and alfentanil, given by paramedics for severe pain before reaching hospital. Researchers want to see which one works better at bringing pain down quickly and safely in an emergency.
For: Severe painFrance