- Ongoing, recruitingPhase II and Phase III (Integrated)
A DOUBLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED TRIAL TO ASSESS SAFETY AND EFFICACY OF SLS-005 (TREHALOSE INJECTION, 90.5 MG/ML FOR INTRAVENOUS INFUSION) FOR THE TREATMENT OF ADULTS WITH SPINOCEREBELLAR ATAXIA
This study is testing a new medicine, SLS-005, for adults with a condition called Spinocerebellar Ataxia type-3 (SCA3). Researchers want to see if it improves movement and daily activities, and if it's safe to use.
For: Spinocerebellar Ataxia type-3 (SCA3)Spain · Portugal · Germany - AuthorisedPhase II and Phase III (Integrated)
SCARR : « Allogenic Umbilical Cord Mesenchymal Stromal Cells for the treatment of chronic renal (cABMR) graft rejection »
This study looks at treating kidney transplant rejection with special cells from umbilical cords. We want to see if these cells can help transplanted kidneys work better for longer in adults who have a specific type of rejection that hasn't responded to usual treatments.
For: Adult Patients kidney transplant recipients who have developed chronic humoral rejection · diagnosed through a kidney biopsy (Banff 2017 Classification) · resistant to conventional treatment (3 injections at one-month intervals of 2g/kg of IVIG)France - AuthorisedTherapeutic exploratory (Phase II)
A Phase II Proof of Concept Multicenter, Randomized, Double-Blind Study to assess the safety and efficacy of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus aureus Treated by DAIR
This study is testing a new way to treat hip or knee joint infections caused by a common germ called Staphylococcus aureus. It's looking at whether using 'phage therapy' – a type of helpful virus – can safely and effectively clear these infections, especially when combined with a procedure to clean the joint.
For: Hip or Knee prosthetic joint infection due to Staphylococcus aureusSpain · Netherlands · France - AuthorisedTherapeutic exploratory (Phase II)
Preoperative use of Romiplostim in thrombocytopenic patients undergoing cardiac surgery. A Phase 3, multicenter randomized double-blinded controlled against placebo study
This study looks at a new medicine called Nplate for people with low platelet counts undergoing heart surgery. It aims to see if Nplate can help prevent bleeding and reduce the need for blood transfusions during and after operations.
For: thrombocytopenic patients undergoing cardiac surgeryFrance - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Does high-dose vitamin B3 supplementation prevent major adverse kidney events during septic shock? A multicenter randomized controlled study.
This study looks at whether a high dose of vitamin B3 can help prevent serious kidney problems in very sick patients called "septic shock." It compares vitamin B3 to a dummy treatment to see if it helps reduce deaths or the need for kidney dialysis.
For: adverse kidney events during septic shockFrance - AuthorisedTherapeutic confirmatory (Phase III)
MAMI Use of the Methoxyflurane as pain-killer in the prehospital management of Acute Myocardial Infarction
This study is looking at how well two different pain medicines, Penthrox (a liquid you breathe in) and morphine, reduce chest pain in people having a heart attack. It wants to see which one works faster and better before they reach the hospital.
For: Acute Myocardial InfarctionFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
Patient reported efficacy of intranasal lysine-aspirin in controlling NSAID-exacerbated respiratory disease.
This study looks at a new way to treat breathing problems caused by pain medicines like ibuprofen or naproxen. It uses a nasal spray with a common painkiller, aspirin, to see if it can improve symptoms like stuffy nose and asthma, and reduce side effects.
For: Nonsteroidal anti-inflammatory drug Exacerbated Respiratory Disease (N-ERD)Belgium - AuthorisedTherapeutic confirmatory (Phase III)
Rituximab therapy in anti-MAG patients with characteristics of good responders: THERAMAG study
This study looks at whether a medicine called rituximab, given with salt water, can help people in the UK with a nerve condition called anti-MAG neuropathy. Researchers want to see if it improves their symptoms over 12 months.
For: anti-MAG neuropathyFrance - AuthorisedTherapeutic confirmatory (Phase III)
EFFICACY OF USUAL MANAGEMENT BY LOCAL ANESTHETIC INFILTRATION IN THE TREATMENT OF CHRONIC IDIOPATHIC ANO-PERINEAL PAIN: A RANDOMIZED DOUBLE-BLIND -CONTROLLED TRIAL
This study is testing if injections of a local anaesthetic drug provide better pain relief for ongoing lower back and bottom pain compared to a salt water injection. We want to see if the anaesthetic can reduce pain significantly after one month.
For: chronic idiopathic ano-perineal painFrance - Ongoing, recruitingTherapeutic use (Phase IV)
Tranexamic acid during excisional burn surgery
This study looks at how a medicine called tranexamic acid affects bleeding during burn surgery. Researchers are comparing it to a salty water solution to see if it reduces blood loss and helps with blood clotting in adults with burn injuries.
For: Burn injuryNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
Evaluation of the benefit and safety of Localized Tissue Hydration (LTH) in the management of chronic common low back pain: Non-randomized single-center phase II study
This study is looking at a new treatment called Localized Tissue Hydration (LTH) for long-lasting lower back pain. It combines LTH with usual care to see if it helps reduce pain significantly after six months. We want to understand if it's safe and effective for people suffering from chronic back discomfort.
For: chronic common low back painFrance - Ongoing, recruitingTherapeutic use (Phase IV)
Efficacy of Intrathecal Morphine for Postoperative Analgesia with or without Suprainguinal Fascia Iliaca Block After Total Hip Arthroplasty: A Double-Blind Randomized Clinical Trial
This study looks at how well different pain relief methods work after hip replacement surgery, focusing on a strong painkiller given near the spine, sometimes with another pain relief injection. It aims to find the best way to manage pain and help people recover quickly.
For: Total hip arthroplasty under spinal anesthesiaBelgium - Ongoing, recruitingTherapeutic exploratory (Phase II)
PhagoDAIR I : A Pilot, Multicenter, Randomized, Non Comparative, Double-Blind Study of Phage Therapy in Patients with Hip or Knee Prosthetic Joint Infection due to Staphylococcus aureus Treated with DAIR and Antibiotic Therapy.
This study looks at a new treatment called 'phage therapy' for hip or knee joint infections caused by *Staphylococcus aureus* (a common germ). It explores if adding phages to standard treatment (cleaning the joint and antibiotics) helps control the infection better.
For: knee or hip prosthetic joint infection (PJI) due to Staphylococcus aureus · with the indication of DAIR and Suppressive Antibiotics Therapy (SAT)France - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Interest of Intra-nodal injection of gentamicin for the treatment of suppurated cat scratch disease's lymphadenitis: a randomized controlled study. "BIGG" : Bartonellosis and intra-nodal injection of gentamicin
This study looks at a new way to treat cat scratch disease, an infection that can cause swollen glands. Doctors are testing if injecting an antibiotic directly into the swollen gland works better than other treatments to reduce swelling and pain.
For: BartonellosisFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
CONCOMITANT ADMINISTRATION OF LICENSED VACCINES AGAINST COVID-19 AND FLU WITH OR WITHOUT MF59 ADJUVANT: A MULTI-CENTRE, RANDOMIZED, SINGLE-BLIND CLINICAL TRIAL TO ASSESS IMMUNOGENICITY IN ADULTS AGED 65 AND OVER
This study looks at giving COVID-19 and flu vaccines at the same time to people aged 65 and over. We want to see how well their bodies respond to both vaccines and if it's safe to have them together. This could make it easier for older adults to stay protected.
For: COVID-19 and fluBelgium · Netherlands - AuthorisedTherapeutic confirmatory (Phase III)
The effect of phoSPHocreatine on mEdical emergency team (met) tREated patients: a randomized clinical trial protocol – SPHERE
This study is looking at a medicine called Neoton to see if it helps very sick patients treated by a special emergency team. It's for adults aged 18 and over who have serious breathing or heart problems, or a sudden change in their awareness.
For: respiratory arrest · threatened airways · tachycardiaItaly - AuthorisedTherapeutic exploratory (Phase II)
Efficacy and safety of allogenic cultured Adipose-derived mesenchymal stromal cell injections on MoUth fibrosis and handicap in patients with Systemic sclEroderma
This study is looking at a new treatment for mouth problems caused by Systemic Sclerosis. It uses special cells injected to see if they can reduce mouth stiffness and improve daily activities. Researchers will check if patients feel better and if the treatment is safe.
For: Systemic sclErodermaFrance