- Ongoing, recruitingTherapeutic use (Phase IV)
Effect of intravenous Lidocaine bolus on the median effective concentration (EC50) of Propofol during target controlled infusion (TCI : Schnider model) for gastroscopy in adult patients : a prospective, randomized, double-blinded study
This study looks at how a common painkiller called lidocaine, given through a drip, might help reduce the amount of a sleep-inducing medicine (propofol) needed for a gastroscopy. It aims to make the procedure smoother and more comfortable for adult patients.
For: GastroscopyBelgium - Ongoing, recruitingTherapeutic use (Phase IV)
Perioperative oral analgesia versus intravenous analgesia for knee arthroscopy, a randomized, double-blinded, non-inferiority trial. OVIKA-trial - S68618
This study, called OVIKA, is looking at the best way to manage pain after a common knee operation. Researchers are comparing pain relief given through an IV drip with pain relief given as tablets to see if tablets work just as well for knee pain.
For: Postoperative pain relief after knee arthroscopyBelgium - Ongoing, recruitingTherapeutic confirmatory (Phase III)
(REGON) Repeated corticosteroid injections around the Greater Occipital Nerve (GON) as prophylactic treatment in chronic cluster headache
This study looks at whether regular injections around a nerve in the back of the head can help prevent severe "cluster headaches." It compares a pain-relieving medicine with a dummy injection to see how long people stay free from their usual headache patterns.
For: Cluster headacheNetherlands - Ongoing, recruitingTherapeutic use (Phase IV)
Selän alueen poikkeava aktiivisuus servikaalisessa dystoniassa
This study looks at how abnormal muscle activity in the back is linked to cervical dystonia, a condition causing twisted neck positions. It compares different botulinum toxin injections (like Botox) to see how well they reduce muscle overactivity and improve symptoms.
For: Servikaalinen dystonia · jossa poikkeavaa lihasaktiivisuutta esiintyy kaulan alueen lihaksissa aiheuttaen tyypillisiä virheasentoja kuten pään kiertymistä · kallistumista ja vapinaa. Servikaalista dystoniaa hoidetaan ensisijaisesti paikallisesti botuliinitoksiinipistoksillaFinland - Ongoing, recruitingPhase III and phase IV (Integrated)
Routine versus selective protamine administration to reduce bleeding complications after transcatheter aortic valve implantation
This study looks at using a medicine called protamine to help prevent serious bleeding after a heart procedure called TAVI. Researchers want to see if giving protamine to everyone or only some patients makes a difference to safety and recovery after TAVI.
For: Aortic stenosisNetherlands · Belgium - AuthorisedTherapeutic confirmatory (Phase III)
ZAMBA: Zoledronic Acid for Modic Back Pain. A randomized, double blind, placebo-controlled, multicenter trial
This study, called ZAMBA, is looking at whether a medicine called zoledronic acid can help people with ongoing back pain. It compares this medicine to a dummy treatment (placebo) to see if it improves daily activities and pain levels over one year.
For: Low Back PainNorway - AuthorisedPhase I and Phase II (Integrated)- Other
Phase 1 (sequential)/2a (parallel), double-blind, multicenter, randomized, controlled study to evaluate the safety and immunogenicity of two administrations of OVX033 sarbecovirus candidate vaccine, given intramuscularly (IM) at one-month interval, at three dose levels, in comparison to placebo, in subjects aged 18 years and older
This study is testing a new vaccine called OVX033 for sarbecoviruses, which include viruses like the one that causes COVID-19. Participants aged 18 and over will receive the vaccine or a dummy injection, to see how safe it is and how well it helps their immune system fight off these viruses.
For: Sarbecoviruses diseaseFrance - Ongoing, recruitingTherapeutic exploratory (Phase II)
Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, immunogenicity and safety of one dose of OVX836 influenza vaccine 480μg, after intramuscular administration in healthy subjects aged 18-59 years
This study is testing a new flu vaccine called OVX836 in healthy adults aged 18 to 59. We want to see how well it prevents the flu, if it's safe, and how the body reacts to it after just one shot. It's a careful study comparing the vaccine to a dummy treatment.
For: Influenza diseaseFrance · Finland · Belgium