- Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Clinical Study to Evaluate the Safety and Efficacy of Topical Administration of Bacteriophage Therapy TP-102 in Patients with Diabetic Foot Infection
This study looks at a new gel treatment, TP-102, for diabetic foot infections. It aims to see if TP-102 can safely and effectively help heal wounds caused by specific bacteria, compared to a dummy gel and standard care.
For: Diabetic foot ulcers infected by Acinetobacter baumannii · Pseudomonas aeruginosa and /or Staphylococcus aureusPoland - AuthorisedPhase III and phase IV (Integrated)
Strategy To Optimize PeriproCeduraL AnticOagulation in Structural Transseptal Interventions (STOP CLOT Trial)
This study, called 'STOP CLOT', is looking at the best ways to use blood thinners during heart procedures like TEER or procedures to close a part of the heart called the left atrial appendage. It aims to prevent problems like blood clots and strokes.
For: periprocedural anticoagulant treatment in patients treated with TEER or transcatheter left atrial appendage closure surgeryPoland - Ongoing, recruitingTherapeutic exploratory (Phase II)
ITPP as an adjunctive treatment for progressive respiratory failure in COVID-19 and other pulmonary parenchymal infections - a randomized, double-blind, non-commercial phase II clinical trial [BREATH2]
This study is looking into a new treatment called ITPP for serious lung infections like COVID-19. It aims to see if ITPP can help people breathe better when given alongside their usual care, and if it's safe to use.
For: COVID-19 and other pulmonary parenchyma infections.Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase 2, randomised, double-blind, placebo-controlled trial to evaluate safety and local tolerability of four weekly administrations of A24110He in subjects with elevated triglyceride plasma concentrations
This study is testing a new medicine called A24110He for people with very high levels of a type of fat (triglycerides) in their blood. We want to see if it's safe and how the body handles it. Participants will receive either the new medicine or a dummy treatment (placebo).
For: Moderate to severe hypertriglyceridemiaSweden - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Phase 1b, Double-blind, Placebo-controlled, Randomised Trial Investigating the Effect of AZD3427 on Renal Perfusion in HFrEF Patients With Renal Impairment Using Positron Emission Tomography (PET)
This study is looking at a new medicine called AZD3427 for people with heart failure and kidney problems. It uses special scans to see if the medicine improves blood flow in the kidneys over 8 days. Doctors want to know if it's safe and how well it helps.
For: Heart failure with reduced ejection fraction · Renal impairmentSweden - Ongoing, recruitingPhase III and phase IV (Integrated)
Evaluation of frequency occurrence persistent pulmonary hypertension of newborns in group of newborns born between 32 and 42 weeks of pregnancy treated by salbutamol
This study looks at how often a lung problem called PPHN happens in babies born between 32 and 42 weeks, when they are given a medicine called salbutamol for breathing difficulties. Researchers want to see if salbutamol affects their breathing.
For: Breathing disorders as a cause of neonatal respiratory failurePoland