- Active not recruitingPHASE2
A Phase 2 Study of Anvumetostat in Participants With MTAP-deleted Advanced NSCLC (MTAPESTRY 201)
This study is looking into a new drug called anvumetostat for people with a specific type of advanced lung cancer (NSCLC) that's missing a gene called MTAP. We want to see how safe the drug is and if it helps by slowing down or shrinking the cancer.
For: MTAP-deleted NSCLCUnited States · Australia · Brazil - Active not recruitingPHASE1, PHASE2
A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
This study is testing a new medicine, Anvumetostat, for people with advanced cancers that are missing a specific gene called MTAP. Researchers want to find the safest dose, see how well it works, and understand its side effects, sometimes given with another cancer drug called Docetaxel.
For: Advanced MTAP-null Solid TumorsUnited States · Australia · Austria - Active not recruitingPHASE1
Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
This study, called MTAPESTRY 104, is testing a new drug called Anvumetostat, alone or with other treatments, for advanced lung cancers that have a specific genetic change (MTAP-deletion). It aims to find the safest and most effective dose.
For: Thoracic Tumors · Non-small Cell Lung CancerUnited States · Argentina · Australia - Active not recruitingPHASE1
A Study Evaluating Anvumetostat in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)
This study looks at new drug combinations for treating advanced stomach, bile duct, and pancreatic cancers. It focuses on cancers with a specific genetic change (MTAP-deletion) to see how safe and effective these new treatments are.
For: Advanced Gastrointestinal, Biliary Tract, and Pancreatic CancersUnited States · Australia · Belgium