- RecruitingPHASE1
Lutathera and ASTX727 in Neuroendocrine Tumours
This study looks at a new way to treat neuroendocrine tumours. It checks if taking a medicine called ASTX727 before Lutathera helps Lutathera work better. Doctors will use special scans to see if this combination treatment improves how your body responds.
For: Neuroendocrine TumorsUnited Kingdom - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Randomized, Open-Label, Phase 1-2 Study of ASTX727 Low Dose (ASTX727 LD) Extended Schedule in Subjects with Lower Risk (IPSS Low or Intermediate-1) Myelodysplastic Syndromes (MDS)
This study is testing a new drug called ASTX727 for people with a type of blood condition called myelodysplastic syndromes (MDS). It aims to see how safe the drug is and if it helps improve blood counts.
For: Myelodysplastic Syndromes (MDS)Spain · Belgium · Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
GFM-DACORAL-DLI: ASTX727 and donor lymphocyte infusions (DLI) after allogeneic stem cell transplantation (ALLO SCT) in very high-risk MDS or AML patients
This study looks at a new drug, ASTX727, with a special treatment called DLI for adults who have very risky forms of blood cancers (MDS or AML) after a stem cell transplant. The aim is to see if this combination helps people stay cancer-free for longer.
For: Patients with high risk myelodysplastic syndrome or acute myeloid leukemiaFrance - Active not recruitingPHASE1
Combination Study of Guadecitabine/ASTX727 and Pembrolizumab
This study looks at combining two medicines, Guadecitabine/ASTX727 and Pembrolizumab, for people with advanced solid tumours, including a type of lung cancer. The main aim is to check if this new combination is safe and what doses work best.
For: Non Small Cell Lung CancerUnited Kingdom