- AuthorisedTherapeutic use (Phase IV)
Studies to gain insight how the drugs PCSK9-inhibitors and statins affect cholesterol and bile acid metabolism
This study looks at how medicines like statins and PCSK9 inhibitors affect cholesterol and digestion in healthy men over 18. Doctors want to understand better how these drugs work to help treat high cholesterol.
For: Healthy volunteersSweden - Ongoing, recruitingTherapeutic use (Phase IV)
A randomized, multicenter, open-label trial comparing the effectiveness of Inclisiran to bempedoic acid on LDL cholesterol (LDL-C) lowering in participants with atherosclerotic cardiovascular disease (VICTORION-CHALLENGE)
This study, called VICTORION-CHALLENGE, is comparing two medicines, Inclisiran and Bempedoic acid, to see which one is better at lowering 'bad' cholesterol (LDL-C) in people who have had heart or circulation problems. We want to find out how much they can reduce cholesterol after about five months.
For: HypercholesterolemiaGermany - Ongoing, recruitingTherapeutic use (Phase IV)
PROgnostic value of precision medicine in patients with Myocardial Infarction and non-obStructive coronary artEries: the PROMISE study
The PROMISE study looks at improving care for people who've had a heart attack but don't have blocked arteries. It checks how different treatments affect their angina (chest pain) and quality of life over a year.
For: Myocardial infarction with non-obstructive coronary arteries (MINOCA)Italy - AuthorisedTherapeutic use (Phase IV)
Statins to Prevent Immune checkpoint inhibitor-induced pRogression of AtheroscLerosis
This study is looking at whether a common medicine called atorvastatin can help prevent or slow down the build-up of fatty deposits (atherosclerosis) in blood vessels for people who are taking certain cancer treatments. It aims to see if the medicine can reduce changes in these deposits over time.
For: AtherosclerosisNetherlands - AuthorisedTherapeutic use (Phase IV)
Cholesterol lowering with atorvastatine for the prevention of gallstones following bariatric surgery (CHOLSTONE): an investigator- blinded randomised controlled trial
This study looks at whether a common cholesterol-lowering medicine called atorvastatin can help prevent gallstones in people who have had weight-loss surgery. Researchers will check for gallstones using ultrasound six months after surgery to see if the medicine makes a difference.
For: Gallstones (chole(cysto)lithiasis) following bariatric surgeryNetherlands