- Ongoing, recruitingTherapeutic exploratory (Phase II)
CDX0159-08: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Barzolvolimab (CDX-0159) in Adults with Active Eosinophilic Esophagitis (The “EvolvE” Study)
This study is looking into a new medicine called barzolvolimab for adults with a condition called Eosinophilic Oesophagitis. We want to see if it helps reduce inflammation in the food pipe and if it's safe to use, compared to a dummy medicine.
For: Eosinophilic EsophagitisSpain · Germany · Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
CDX0159-07: A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Dose ranging Study to Assess the Efficacy and Safety of CDX 0159 in Patients with Chronic Inducible Urticaria
This study is testing a new medicine called Barzolvolimab for people with chronic inducible urticaria (hives that can be triggered). It aims to see if the medicine can stop hives from appearing when triggered by cold or scratching, and if it's safe to use.
For: Chronic Inducible UrticariaPoland · Bulgaria · Latvia - Active not recruitingPHASE3
A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria (CSU)
This study is testing a new medicine, barzolvolimab, for people with chronic spontaneous urticaria (CSU), also known as chronic hives. It aims to see if the medicine is safe and helps reduce hives better than a dummy medicine (placebo) for those whose current treatments aren't enough.
For: Chronic Spontaneous UrticariaUnited States · Australia · Bulgaria - RecruitingPHASE3
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)
This study looks at a new drug, barzolvolimab, for people with cold urticaria or symptomatic dermographism – skin conditions causing hives or itching from cold or scratching. It checks if the drug is safe and helps when usual antihistamines don't work.
For: Chronic Inducible Urticaria · Cold Urticaria · Cold-Induced UrticariaUnited States · Germany · Lithuania