- RecruitingTherapeutic exploratory (Phase II)
A phase II trial of belimumab in combination with rituximab/venetoclax in patients with refractory or relapsed chronic lymphocytic leukemia
This study looks into a new treatment for chronic lymphocytic leukaemia (CLL) that has come back or is hard to treat. It combines a drug called belimumab with existing treatments. Researchers want to see if this combination can get rid of all signs of the cancer in the blood.
For: refractory or relapsed chronic lymphocytic leukemiaGermany - Not yet recruitingPhase III
A Phase III trial evaluating the response to belimumab after rituximab in lupus patients who have high levels of IgA2 anti-DNA antibodies
This clinical trial looks at whether a medicine called belimumab helps people with lupus after they have rituximab treatment. Researchers want to see if testing for a specific antibody can identify who will benefit most from this drug combination, helping to prevent painful symptom flare-ups in the future.
For: Systemic lupus erythematosusUnited Kingdom · England · Wales - RecruitingPHASE3
A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE)
This study looks at the long-term safety and how well a medicine called belimumab works for people with lung problems linked to certain conditions like lupus. It's for people who've already been in a previous study.
For: Connective Tissue DiseasesUnited States · Argentina · Australia - RecruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
This study looks at a new treatment called belimumab for adults with a lung condition linked to scleroderma. Researchers want to see if it improves lung function and other symptoms, like skin thickening, compared to a dummy treatment.
For: Systemic Sclerosis Associated Interstitial Lung Disease · Scleroderma, SystemicUnited States · Argentina · Australia - Active not recruitingPHASE2
Study of Subcutaneous (SC) Belimumab in Pediatric Participants With Systemic Lupus Erythematosus (SLE)
This study is looking at a new way to give a medicine called belimumab to children aged 5 to 17 with lupus. It aims to see how safe and effective a new injection form of the medicine is, similar to how adults use it.
For: Systemic Lupus ErythematosusUnited States · Argentina · Germany - RecruitingPHASE1
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD Participants
This study is testing a new medicine, GSK4527363, for lupus and lung conditions related to connective tissue diseases. It's looking at how safe it is, how the body handles it, and if it causes side effects in healthy people and those with these conditions.
For: Systemic Lupus ErythematosusUnited States · Argentina · Brazil - RecruitingPHASE3
A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease
This study looks at a new treatment called belimumab for a lung condition called interstitial lung disease (ILD). ILD makes lungs stiff and is often linked to conditions like lupus. We want to see if belimumab can help stabilise or improve lung health and symptoms.
For: Lung Diseases, InterstitialUnited States · Argentina · Australia