- Active not recruitingPHASE1
DAREON™-9: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With Small Cell Lung Cancer When Taken Together With a Single Agent Chemotherapy
This study is for adults with a type of lung cancer called small cell lung cancer that has spread. It checks how well a new medicine called BI 764532, given with standard chemotherapy, is tolerated. The main goal is to find the safest dose of BI 764532.
For: Small Cell Lung Carcinoma (SCLC)United States · France · Germany - AuthorisedTherapeutic exploratory (Phase II)
A Phase II, single-arm trial on the addition of the DLL3xCD3 bispecific T-cell engager obrixtamig (BI 764532) to standard-of-care platinum-based first-line treatment of advanced large-cell neuroendocrine carcinoma of the lung (ALPINE 2)
This clinical trial is testing a new immunotherapy drug called obrixtamig. Researchers want to see if adding it to standard chemotherapy helps adults with an advanced, rare type of lung cancer live longer. Everyone who takes part in this study receives both obrixtamig and standard chemotherapy.
For: Male and female adult patients with locally advanced or metastatic large-cell neuroendocrine carcinoma of the lung not eligible for curative treatmentGermany - Active not recruitingPHASE1
DAREON™-7: A Study to Test How Well Different Doses of BI 764532 in Addition to Chemotherapy Are Tolerated by People With Advanced Neuroendocrine Cancers
This study looks at a new medicine, BI 764532, combined with chemotherapy for advanced neuroendocrine cancers. It aims to find safe doses and see if it helps patients whose cancers have a specific marker called DLL3.
For: Neuroendocrine NeoplasmsUnited States · Belgium · France - Active not recruitingPHASE1
A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3
This study is for adults with a brain tumour called glioma, where previous treatments haven't worked. It's looking to find the safest highest dose of a new drug, BI 764532, which helps your immune system fight the cancer.
For: GliomaUnited States · Austria · Germany