- Active not recruitingNA
National Clinical-biological Prospective Cohort of Incident Cases of Aggressive Fibromatosis (ALTITUDES)
This study is gathering information on a rare condition called aggressive fibromatosis (AF) in France. It aims to build the largest collection of data from new AF patients, including tissue and blood samples, to better understand this condition and find clearer ways to treat it.
For: Aggressive FibromatosisFrance - RecruitingNA
Prediction in Silico of Pathological Response in a Prospective Cohort Study of Early Breast Cancer Patients
This study aims to better predict how well breast cancer treatments will work for patients with early-stage breast cancer. By collecting detailed information from patients, researchers hope to develop a tool to help doctors choose the best treatment for each person.
For: Breast CancerFrance - Active not recruitingPHASE2
Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia
This study investigates if metformin, a common diabetes drug, can prevent oral cancer in people with white or red patches in their mouth (leukoplakia or erythroplakia). Participants will take either metformin or a dummy pill for 24 weeks.
For: Erythroplakia · Oral LeukoplakiaUnited States · Canada - RecruitingNA
The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis
This study looks at how a specific gut germ called Ruminococcus gnavus might be linked to a condition called spondyloarthritis. Researchers are comparing gut samples from people with the condition and healthy individuals to understand this connection better.
For: Spondyloarthritis · Ruminococcus GnavusFrance - RecruitingNA
Analysis of Circulating Tumor mArkers in Blood 4 - ALCINA 4
ALCINA 4 is a study looking at cancer markers in blood. We want to see if a simple blood test can help us understand cancer better, perhaps even replacing painful biopsies. It won't change your current cancer treatment.
For: CancerFrance - RecruitingNA
Cohort of Patients With Systemic Sclerosis Within the Framework of the RESO Reference Centre
This study looks at how scleroderma (a rare condition affecting skin and organs) changes over 5 years. Researchers collect blood and tissue samples to better understand this disease, as there is currently no cure. They hope to improve future treatments.
For: Scleroderma · Systemic SclerosisFrance - RecruitingPHASE3
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
This study looks at whether some people with early triple-negative breast cancer who had a good response to initial treatment can skip further immunotherapy after surgery. It compares continuing pembrolizumab with just being watched closely to see if both approaches are equally good at preventing cancer from coming back.
For: Anatomic Stage II Breast Cancer AJCC v8 · Early Stage Triple-Negative Breast Carcinoma · Anatomic Stage IIIA Breast Cancer AJCC v8United States · Canada · Puerto Rico - RecruitingNA
Biomoleculars Markers of Sensitivity to Pre- and Post-operative Chemotherapy of Gastric and Cardia Adenocarcinomas: a Pilot Study
This study looks for clues in stomach cancer cells to predict if chemotherapy will work best *before* or *after* surgery. The goal is to help doctors choose the right treatment at the right time to give patients the best chance.
For: Gastric and Cardia AdenocarcinomasFrance - RecruitingNA
MICROBIOTA AND BLADDER CANCER
This study looks into how tiny living things, called microbes, in the bladder might be linked to bladder cancer. Researchers are comparing microbes in healthy and cancerous bladder tissue to understand if some microbes play a role in developing the disease.
For: Bladder (Urothelial, Transitional Cell) CancerFrance - Recruiting
Prospective Evaluation of AI R&D Tool for Patient Stratification - MoA Evaluation in Triple Negative Breast Cancer (PEAR-MET)
This study is testing a new tool for people with advanced triple-negative breast cancer. It uses a small sample of your tumour to see how it might react to different treatments. This helps researchers understand how to better choose treatments in the future, aiming to improve care for patients.
For: Breast Cancer · Triple Negative Breast CancerUnited Kingdom