- RecruitingPHASE3
Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial
This study compares two common medicines, azathioprine and methotrexate, when used with adalimumab for Crohn's disease. Researchers want to see which combination works best to improve symptoms and healing in the gut, hoping to find a safer and more effective treatment.
For: Crohn Disease · Azathioprine · MethotrexateFrance - Recruiting
Basal Plasma Lithium Levels and Suicidal Events
This study looks at how natural lithium levels in the body might be linked to suicidal thoughts and actions in people with depression. It compares those with and without a history of suicidal events to understand how lithium could help prevent them.
For: Major Depressive Disorder · Suicidal Behavior · Bipolar DisorderFrance - Recruiting
Monitoring of Patients With Low-grade Gliomas Using Circulating miRNA
This study looks at using tiny molecules called microRNAs from blood samples to find out if glioma brain tumours are coming back earlier. This could help doctors treat Grade 2 and 3 brain tumours sooner, giving patients better care.
For: Glioma · miRNA · Low-grade GliomaFrance - RecruitingNA
Joint Thoracic Oncology Research Unit of LYon: Lung cancerS DatabaSE (ULYSSE)
This study in Lyon, France, is collecting information and samples from people with lung cancer and similar chest cancers. Researchers want to learn more about these cancers to help improve treatments in the future. It involves giving blood and answering questionnaires.
For: Lung CancerFrance - RecruitingNA
Detection of ISUP≥2 Prostate Cancers Using Multiparametric MRI: Prospective Multicenter Comparison of the PI-RADS Score and an Artificial Intelligence System
This study is testing a new artificial intelligence (AI) system to better detect important prostate cancers using MRI scans. It aims to see if this AI helps doctors find these cancers more reliably and consistently than current methods, especially in real-world settings across different hospitals.
For: Prostate CancerFrance - RecruitingNA
Role of A2A Receptor in Hypercholesterolemic Patients
This study looks at how high cholesterol affects the body's natural defences and blood vessel health. Researchers want to understand if a specific molecule, the A2A receptor, changes in people with high cholesterol and if current treatments help. It could lead to better ways to prevent heart problems.
For: HypercholesterolemiaFrance - Not yet recruiting
Translational Potential of ex Vivo Gene Therapy in GM2 Gangliosidosis
This study is looking at a new way to treat rare conditions called Tay-Sachs and Sandhoff disease. Researchers are testing a gene therapy using a person's own blood cells to see if it can help correct the problem causing these diseases. The aim is to find an effective treatment for people.
For: Tay-Sachs Disease Ganglioside · Sandhoff Disease GangliosideFrance - Recruiting
Neuropathological Changes of the Intestinal Wall in Patients With Bowel Evacuation Disorders
This study looks into why some people have long-term problems with constipation or emptying their bowels. Researchers are examining tiny nerves in bowel tissue samples and blood to understand what might be causing these issues, hoping to find new ways to treat them effectively.
For: Defecation Disorder · Neuropathology · Autoimmune DiseasesGermany - RecruitingNA
Identification of Innovative Biomarkers to Predict Outcomes in Hepatocellular Carcinoma Treated With Tremelimumab and Durvalumab
This study looks for new clues in blood samples to predict how well liver cancer patients will respond to a specific combination of immunotherapy drugs, tremelimumab and durvalumab. It aims to find out why some patients do better than others with this treatment.
For: Hepatocellular CarcinomaFrance - RecruitingNA
Integrative Molecular Analysis of Individual Radiosensitivity in Pediatric Oncology
This study looks at how children with cancer react to radiotherapy. We're using blood samples to understand why some children might be more sensitive to radiation than others, aiming to make treatments safer and more effective for young patients.
For: Radiosensitivity · Pediatric Cancer · Radiation ToxicityFrance - Active not recruitingPHASE3
3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erithematosus Study Protocol
This study looks at lupus (SLE) to understand why some people get flares and how treatments work. Researchers will collect samples like blood and urine to find better ways to predict flares and personalise treatments.
For: Systemic Lupus Erythematosus (SLE)France - Active not recruitingNA
Prognostic Impact of Neopterin on Resumption of Walking After a Fracture of the Upper Neck of the Femur in the Elderly
This study looks at hip fractures in older people. We want to see if a chemical called neopterin in the blood can help predict how well someone will recover, especially if they'll be able to walk again like before. This could help doctors give better care.
For: Fracture of Neck of Femur · Resumption of WalkingFrance - Recruiting
IL17 Rate and Spondyloarthritis
This study looks at a new way to help doctors choose the best biological medicine for people with a type of arthritis called spondyloarthritis. By checking a special reaction in your blood, researchers hope to predict which treatment will work best for you.
For: SpondylarthritisFrance - Recruiting
Identifying New Genetic Causes to Development Disorders
This study looks for new genetic reasons behind conditions affecting growth, puberty, and sex development. By studying blood samples, researchers hope to find new genetic changes that cause these conditions and understand them better. This could lead to better ways to help people in the future.
For: Disorders of Sex Development · Growth Disorders · Puberty DisordersFrance - RecruitingNA
Creation of a French South-Eastern Database and DNA-bank of Congenital Heart Disease to Explore the Genetic Pathways
This study is setting up a local collection of blood samples and health information from people in South-East France with heart problems they were born with. This will help scientists better understand why these heart problems happen and how to treat them.
For: Congenital Heart DefectsFrance - RecruitingNA
Exploration of Adaptive Antitumoral Immune Cells Through Lymphapheresis in Cancer Patients : ALCYTA
This study looks for special immune cells in cancer patients who might be responding well to treatment or experiencing side effects. We want to understand how their immune system fights cancer.
For: Cancer · Immune System or Toxicities SuspectedFrance - RecruitingNA
The Impact of Abdominal Wall Closure Technique on Incidence of Incisional Hernia in Kidney Transplantation
This study looks at how different ways of stitching up a wound after a kidney transplant might affect whether a hernia develops later. It hopes to find better ways to close wounds to reduce problems for patients.
For: Surgery--ComplicationsUnited Kingdom - Active not recruiting
Correlation Between TILs and Blood Cell Counts in Triple Negative Breast Cancer Patients
This study, called PERCEPTION, is for women with triple negative breast cancer. It looks at how blood cell counts and special immune cells in tumours are linked, both before and after surgery. It also explores if these can predict if the cancer might come back.
For: Triple Negative Breast CancerFrance - RecruitingNA
Establishment of a Prospective Clinical-biological Database
This study is building a confidential database of samples and information from sarcoma patients in the UK. Researchers will use this to learn more about sarcoma and help develop new treatments to improve care for people with this type of cancer.
For: SarcomaFrance - RecruitingNA
Prospective Cohort of Patients With Newly Diagnosed Glioblastoma: Analysis of MMP2 and MMP9 Expression and Correlation to Neuro-imaging Features.
This study looks at how certain proteins, MMP2 and MMP9, behave in adults newly diagnosed with a type of brain tumour called glioblastoma. We want to see if changes in these proteins in blood and tumour samples, along with their activity, can tell us more about the tumour and how it responds to treatment.
For: Brain TumorFrance - RecruitingNA
Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects
This study looks at special immune cells called Natural Killer (NK) cells in people with severe asthma. We want to understand if these cells act differently in severe asthma compared to healthy people, hoping to find new ways to understand and treat the condition, especially during flare-ups.
For: Asthma AcuteFrance - RecruitingNA
Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence
This study looks into causes of feeling excessively sleepy during the day. Researchers want to collect information from people with long-term sleep problems to better understand why some people feel very drowsy. This could lead to better ways to diagnose and help those affected.
For: Somnolence Disorder, ExcessiveFrance - Recruiting
Study of Neonatal IgG Fc Receptor Expression in Natural Killer T Cells Expressing an Invariant T Receptor : Implication in the Pathophysiology of Systemic Lupus
This study looks at certain immune cells and proteins in people with lupus. We want to understand how these cells change in active lupus compared to inactive lupus to learn more about the disease and how new treatments might work.
For: Systemic Lupus Erythematosus · PhysiopathologyFrance - RecruitingNA
Screening for Familial Hypercholesterolemia in Children
This study looks into improving how we find a common inherited condition called Familial Hypercholesterolemia (FH) in children. FH causes high cholesterol and can be treated easily. The study wants to see if checking all children for FH helps catch it earlier, improving their health long-term.
For: Hypercholesterolemia, FamilialFrance - RecruitingNA
French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis
This study looks at why people with Amyotrophic Lateral Sclerosis (ALS) lose weight. Researchers will collect blood samples and ask questions to understand this better. They hope to find ways to help people with ALS keep their weight stable, which could improve their health and quality of life.
For: Amyotrophic Lateral SclerosisFrance - RecruitingNA
Analysis of Circulating Tumor mArkers in Blood 4 - ALCINA 4
ALCINA 4 is a study looking at cancer markers in blood. We want to see if a simple blood test can help us understand cancer better, perhaps even replacing painful biopsies. It won't change your current cancer treatment.
For: CancerFrance - Active not recruiting
Orientation of the Lymphocyte Response to the Occurrence of Atherosclerotic Complications After Kidney Transplantation
This study looks at how your body's defence system (immune system) affects blood vessel problems (atherosclerosis) after a kidney transplant. Researchers want to understand if a certain type of immune cell (regulatory T cells) plays a role in these complications.
For: Disorder Related to Renal TransplantationFrance - Not yet recruitingNA
Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.
This study looks at how being at a moderate altitude, like on a mountain, affects your memory for future plans. It also checks if breathing normal air or extra oxygen can help improve this memory if it's affected.
For: Hypoxia · Hypoxia Brain · Hypoxia Altitude Simulation TestFrance - Recruiting
Tanycytes in Alzheimer's Disease and Frontotemporal Dementia
This study looks into how certain brain cells, called tanycytes, might be involved in Alzheimer's disease and a similar condition called frontotemporal dementia. Researchers want to see if how these cells handle a hormone called leptin changes early in these diseases.
For: Alzheimer Disease · Frontotemporal DementiaFrance - RecruitingNA
Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
This study looks at a condition called 'clonal hematopoiesis of indeterminate potential' (CHIP) and whether it might be linked to unexplained blood clots in the lungs (pulmonary embolism). Researchers want to see if CHIP is common in these cases and plays a role in why they happen.
For: Pulmonary Embolism · HematopoiesisFrance - RecruitingNA
Pilot Study of Microvesicles in Pre-eclamptic and Non-pre-eclamptic Women With Threatened Preterm Delivery
This study looks at tiny particles called microvesicles in the blood of pregnant women. We want to see if these particles are different in women with pre-eclampsia compared to those without it. This could help us understand pre-eclampsia better.
For: Pre-EclampsiaFrance - Not yet recruiting
Study of the Hypothalamic Microglial Response as a Function of a Meal's Lipid Content in Humans. A Single-center Prospective Cohort Study in Healthy Male Subjects
This study looks at how different types of meals affect the brain in healthy men. Specifically, it uses brain scans to see how a part of the brain called the hypothalamus reacts to meals with different fat levels, helping us understand how our bodies control eating.
For: PathophysiologyFrance - Active not recruiting
Biopsychosocial Markers of Addiction in Opioid Users: an Integrated Approach
This study looks at how addiction to opioids affects people in France. Researchers will collect blood, saliva, and hair samples. They want to understand how things like personal experiences, social life, and biology work together to make opioid use disorder worse, hoping to find better ways to help.
For: Opioid Use DisorderFrance - Active not recruitingNA
Predictive Role of New Biomarkers for Hypersensitive Patients to Radiation in Breast Cancer (BIORISE)
This study looks for proteins in blood that predict how some breast cancer patients react to radiotherapy. It aims to develop a blood test to identify patients who might have a stronger reaction, helping doctors personalise treatment.
For: Breast CancerFrance - Not yet recruitingPHASE2
Cabo-POLARIS : A Trial to Evaluate Cabozantinib Among Haemodialysied Patients
This study looks at a new drug, cabozantinib, for kidney cancer patients who are on dialysis. It aims to understand if the treatment is safe and works well for them, as they are often not included in other trials.
For: Cancer of KidneyFrance - Active not recruiting
Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors
This study looks at how gut germs affect long-term health in people who've had gullet cancer surgery. We're hoping to find new ways to spot and treat gut problems to improve their quality of life after cancer.
For: Oesophageal Cancer · Quality of Life · Bacterial OvergrowthUnited Kingdom - Active not recruiting
Long-Term Follow-Up of TX200-TR101 (STEADFAST Long Term)
This study is checking on people who had a special treatment (TX200-TR101) for kidney transplant rejection up to 15 years ago. Researchers want to see how everyone is doing long-term to make sure the treatment is safe and well-tolerated.
For: Kidney Transplant Rejection · End Stage Renal DiseaseBelgium · Netherlands · United Kingdom