- Ongoing, recruitingPhase II and Phase III (Integrated)
A Phase 2/3 Study of Navtemadlin as Maintenance Therapy in Subjects with TP53WT Advanced or Recurrent Endometrial Cancer Who Responded to Chemotherapy
This study looks at a new drug, Navtemadlin, for women with advanced endometrial cancer. It's for those who responded well to previous chemotherapy. The aim is to see if Navtemadlin can help keep the cancer from coming back for longer.
For: Advanced or Recurrent Endometrial CancerLithuania · Estonia · Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A trial of prednisolone in combination with SPI-62 or placebo in participants with polymyalgia rheumatica (PMR)
This study is looking into new ways to treat polymyalgia rheumatica (PMR), a condition that causes muscle pain and stiffness. It will compare a new medicine, SPI-62, with a dummy pill, alongside the usual Prednisolone treatment, to see if it can help improve symptoms.
For: Polymyalgia rheumatica (PMR)Germany · Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
TSPO ligands in the treatment of depression: proof-of-concept of efficacy and underlying mechanisms of action
This study is testing a new capsule treatment for different types of depression. Researchers want to see if it helps improve mood and understand how it works in the body. It's an early-stage study open to adults aged 18 and over.
For: Unipolar/bipolar depressive disorderGermany