- AuthorisedTherapeutic use (Phase IV)
Clinical impact of pharmacokinetic monitoring of antibiotics in critically ill patients
This study looks at how well antibiotics work in very ill patients in intensive care. It checks if carefully tracking antibiotic levels in their bodies helps treat infections and improve how quickly they recover, including how long they stay in hospital.
For: Critical Patients admitted to the ICUSpain - Ongoing, recruitingTherapeutic confirmatory (Phase III)
COTRIVAP - Efficacy of cotrimoxazole as a de-escalation treatment of Ventilator-Associated Pneumonia in intensive care unit. Multicentric non-inferiority randomised controlled trial
This study is looking at whether a common antibiotic, co-trimoxazole, can be used to treat pneumonia in patients on a ventilator in intensive care. It compares it to standard treatments to see if it works just as well and is safe.
For: Intensive Care · Ventilator-associated PneumoniaFrance - Ongoing, recruitingTherapeutic use (Phase IV)
SAFE study: Stopping Antibiotics after 3 days for the treatment of FEbrile Neutropenia in Haematology patients, a randomized open-label non-inferiority trial
This study looks at treating a fever and low white blood cell count in cancer patients called febrile neutropenia. It compares giving antibiotics for a short time versus longer, checking if the shorter treatment is just as safe and effective.
For: Febrile neutropeniaBelgium - AuthorisedTherapeutic exploratory (Phase II)
Nebulized Amikacine for Ventilator associated gram negative Pneumonia in ECMO veno-arterial patients: A randomized Pilot Study (NAVAP-ECMO)
This study looks at a new way to treat lung infections in very sick patients on a special life support machine. We're testing if giving a specific antibiotic directly into the lungs helps clear the infection better and if it's safe.
For: gram-negative bacillus pneumonia acquired during mechanical ventilation in patients receiving Extracorporeal Membrane veno-arterial oxygenationFrance - AuthorisedTherapeutic confirmatory (Phase III)
BICCS - Beta-lactam Intermittent versus Continuous infusion and Combination antibiotic therapy in Sepsis
This study looks at different ways to give antibiotics to people with a serious infection called sepsis. Researchers want to see if continuous treatment or using different antibiotics together can help people recover better and reduce deaths in the first 30 days.
For: antibiotic therapy in SepsisFrance - AuthorisedTherapeutic use (Phase IV)
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.
This study looks at how well antibiotics work in very sick patients. Researchers want to make sure these important medicines reach the right levels in the body to fight serious infections effectively and safely. It's about getting the dose just right.
For: Serious infections in critically ill patients treated with antibioticsFrance